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A unique anti-inflammatory property of IgG, independent of antigen specificity, is described. IgG with modification of the heavy-chain glycan on asparagine 297 by the streptococcal enzyme endo-beta-N-acetylglucosaminidase (EndoS) induced a dominant suppression of immune complex (IC)-mediated inflammation, such as arthritis, through destabilization of local ICs by fragment crystallizable-fragment c
This thesis investigates if it is possible to measure the plunger position in a Ledex 282352-023 solenoid actuator without the use of external sensors. To do this, various different methods, all based on comparing the current response to the applied voltage were evaluated from different categories such as calculation time, reliability and distinct position levels. The method that performed best in
Presentation template with LiU typography The management of enhancement requests – a customer perspective EBSCO Systems Swedish User Group Annual meeting 2023 Eva Sejmyr, Senior Librarian and System Manager, Linköping University Library Let's explore the management of enhancement requests from a customer perspective, with examples from Linköping University Library and ESSUG. 2023-04-26The manageme
https://www.ub.lu.se/sites/ub.lu.se/files/2023-05/Enhancement%20requests%202023.pdf - 2026-07-19
Ett smartare Sverige Sacos kongress 2025 Verksamhets rapport januari–juni 2025 1/14 Uppföljning av verksamheten första halvåret 2025 Sammanfattning Under det första halvåret 2025 har Saco bedrivit aktivt påverkansarbete och mediegenomslaget har varit starkt. Därutöver har nya aktiviteter genomförts för att ytterligare stärka samverkan och stöd inom federationen. Rapporter, remissvar, debattartikl
Video capsule endoscopy (VCE), perfomed by ingesting a small vitamin-sized camera pill, was developed over a period of a couple of decades and –since its introduction in clinical practice at the dawn of the millennium– has become an essential tool in the diagnosis and management of small bowel (SB) diseases. At the same time, other fields such as minimally invasive diagnosis of other parts of the
Background: To demonstrate extended protection against meningococcal serogroup B (MenB) disease after MenB-FHbp (bivalent rLP2086) vaccination, this study evaluated immunopersistence through 26 months following MenB-FHbp boosting after 2 or 3 primary doses in adolescents. Study design: This phase 3, open-label study was an extension of 3 phase 2 studies with participants aged 11–18 years randomize
Nationella forskarskolan om åldrande och hälsa Verksamhetsberättelse 2025 CASE - Centre for Ageing and Supportive Environments Foto: Kennet Ruona Centre for Ageing and Supportive Environments Verksamhetsberättelse 2025 2 Förord Med denna verksamhetsrapport ger vi en kortfattad sammanfattning av den verksamhet som bedrivits inom Centre for Ageing and Supportive Environments (CASE) under 2025. CASE
https://www.case.lu.se/sites/case.lu.se/files/2026-03/Verksamhetsber%C3%A4ttelse%20CASE%202025.pdf - 2026-07-19
This bachelor’s thesis in Historical Archaeology concerns how the royal medals of the Swedish King Gustav III (1756-1792) functioned as a means of political propaganda, namely in what ways an official legitimizing narrative was created about the country’s economy and the role of the King herein, through the images and texts of the royal medals. Inspired by Clifford Geertz’ anthropological perspec
BACKGROUND: There was a decrease 1982-2001 in smoking during early pregnancy in Swedish women. We sought to determine whether there was a parallel decrease in socio-economic inequality in smoking. METHODS: Registry data indicating educational level and smoking status at first antenatal visit in all 2,022,469 pregnancies in Sweden 1982-2001 was analysed. Prevalence differences, odds ratios based on
Background: Systemic Lupus Erythematosus (SLE) is an autoimmune disease encompassing a wide range of symptoms that can emanate from pathology in virtually any organ system. Severe SLE includes involvement of the central nervous system and kidneys. One of the hallmarks of the disease is a multitude of autoantibodies, indicating a breakdown in self tolerance. The corresponding antigens have been fou
Pyranose 2-oxidase (P20x) has several proposed biotechnological applications such as a bio-component in biofuel cells or for carbohydrate transformations. To improve some of the catalytic properties of P20x from Trametes multicolor, we selected a semi-rational approach of enzyme engineering, saturation mutagenesis of active-site residues and subsequent screening of mutant libraries for improved ac
Streptococcus pyogenes infects over 700 million people worldwide annually. Immune evasion strategies employed by the bacteria include binding of the complement inhibitors, C4b-binding protein (C4BP) and Factor H in a human-specific manner. We recently showed that human IgG increased C4BP binding to the bacterial surface, which promoted streptococcal immune evasion and increased mortality in mice.
Presented here is an engineered protein domain, based on Protein A, that displays a calcium-dependent binding to antibodies. This protein, ZCa, is shown to efficiently function as an affinity ligand for mild purification of antibodies through elution with ethylenediaminetetraacetic acid. Antibodies are commonly used tools in the area of biological sciences and as therapeutics, and the most commonl
