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Group B Streptococcus (GBS) is a leading cause of invasive bacterial infections in human newborns. A key GBS virulence factor is its capsular polysaccharide (CPS), displaying terminal sialic acid (Sia) residues which block deposition and activation of complement on the bacterial surface. We recently demonstrated that GBS Sia can bind human CD33-related Sia-recognizing immunoglobulin (Ig) superfami

Background: A significant proportion of patients with asthma have persistent symptoms despite treatment with inhaled glucocorticosteroids. Objective: We hypothesized that in these patients, the alveolar parenchyma is subjected to mast cell-associated alterations. Methods: Bronchial and transbronchial biopsies from healthy controls (n = 8), patients with allergic rhinitis (n = 8), and patients with

EndoS from Streptococcus pyogenes efficiently hydrolyzes the functionally important and conserved N-linked glycan of IgG in human blood. Repeated i.v. administration of EndoS in rabbits completely hydrolyzes the glycans of the whole IgG pool, despite the generation of anti-EndoS antibodies. EndoS administration had no apparent effects on the health of the animals. EndoS hydrolysis of the IgG glyca

Regular prophylactic treatment with factor VIII (FVIII) and factor IX (FIX) concentrates in hemophilia A and B, respectively, is introduced in early infancy and has resulted in dramatic improvement of the conditions. Recombinant FVIII and FIX concentrates have been available for > 25 years and have been modified and refined through the years; however, unfortunately frequent intravenous administrat

Lymphocytes from human peripheral blood were separated by Countercurrent distribution (CCD) in a charged aqueous two-phase system composed of Dextran T 500 and polyethylene glycol 6000. Maximal responses to the T-cell mitogens phytohemagglutinin and concanavalin A were detected in a part of the distribution corresponding to the area where the highest percentage of E rosetting cells were seen. Anti

Protein ADP-ribosylation is a reversible post-translational modification that regulates important cellular functions. The identification of modified proteins has proven challenging and has mainly been achieved via enrichment methodologies. Random mutagenesis was used here to develop an engineered Af1521 ADP-ribose binding macro domain protein with 1000-fold increased affinity towards ADP-ribose. T

Det är i brottmålsprocesser ovanligt att den anklagades ålder är oklar. Men när den är det så ställs stora krav på tillräckligt precisa metoder eftersom det spelar stor roll vad den anklagade bedöms ha för ålder. De svenska påföljdsbestämmelserna särbehandlar nämligen unga lagöverträdare på olika sätt beroende på ålder. Socialstyrelsen har tagit ställning till frågan huruvida tandmognadsbedömningIn criminal proceedings it is unusual that the age of the accused is unclear. But when it is, it is of utmost importance that the methods used to determine the age are sufficiently precise because the expected age of the accised is of paramount importance. The Swedish penalties provisions specifically deal with juvenile offenders in different ways depending on age. Socialstyrelsen has considered t

We have characterized 2 distinct mechanisms through which infectious agents may promote platelet adhesion and thrombus formation in flowing blood, thus contributing to the progression of disease. In one case, the process initiates when the integrin alpha(IIb)beta(3) mediates platelet arrest onto immobilized bacterial constituents that have bound plasma fibrinogen. If blood contains antibodies agai

Modulenthus is a company in the wood house industry that builds houses in volumes. Volume building means that Modulenthus builds predecorated house volumes in a factory and transports these to the building sites where they are being put together to complete detached houses. The purpose of these Master Thesis is that, on the basis of Modulenthus conditions and wishes, evaluate a possible using of a

The royal Danish-Norwegian flagship Gribshunden, launched in 1485, was amongthe earliest northern European warships purpose-built to carry artillery. However, King Hans employed his vessel as far more than a weapons platform. The ship was his ‘floating castle’, fulfilling all the various purposes of a land redoubt. At its loss in 1495 enroute to a political summit in Kalmar, where Hans expected to

Tim Ingold’s critique of mainstream modern experiences of human–environmental relations is highly persuasive but almost completely disconnected from considerations of social relations of power and inequality. His emphasis on the phenomenology of local relations seems inevitably detached from the logic of abstract economic and political systems. This article proposes that the distortions of experie

Studiens syfte var att undersöka hbtq+-personers upplevelser och hantering av minoritetsstress i nära relationer samt upplevda konsekvenser på hälsan och de nära relationerna. Detta gjordes genom semistrukturerade intervjuer med tio personer, som bröt mot cis- och/eller heteronormen. En tematisk analys av berättelserna utmynnade i tre huvudteman: Omvänd skuld- och ansvarsfördelning, Två sidor av mThe aim of this study was to explore how LGBTQ+ people experience and cope with minority stress in their close relationships, how minority stress affects the relationships and what health implications might come from it. Ten semi-structured interviews were conducted with LGBTQ+ individuals. A thematic analysis of the stories resulted in three main themes: Reverse guilt and liability, Two sides of