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Effects of chronic citalopram treatment on central and peripheral spontaneous open-field behaviours in rats

The spontaneous open-field behavioural effects of 10 days of chronic treatment with two clinical doses (10 and 20 mg/kg daily) and one high/toxic dose (100 mg/kg daily) of the selective serotonin reuptake inhibitor citalopram (delivered subcutaneously by implanted osmotic pumps) were examined in rats. Central and peripheral arena locomotor and rearing activities were recorded simultaneously, and t

Biologi, Evolutionsbiologi - Masterprogram

Masterprogrammet i evolutionsbiologi har stark forskningsanknytning. Våra lärare är världsledande inom sina områden, och programmets innehåll anpassas till forskningsfronten. Under utbildningen får du praktisk erfarenhet av att designa experiment och samla in data med hjälp av de senaste metoderna. Du lär dig analysera olika typer av biologiska data för att fastställa vad som orsakat evolutionära The Master’s programme in Evolutionary Biology has strong connections with research. Our teaching staff possess world-leading expertise in their fields and the programme content is adapted to the research front. During the programme you will gain practical experience of designing experiments and collecting data using the latest methods. You will learn how to analyse different types of biological

Miljöstrategisk styrning - Masterprogram

EMP studies are rooted in interdisciplinary learning, global perspectives and practical application. EMP addresses both environmental policy and environmental management, grounded in the firm belief that leaders in both fields require a dual perspective. Alumni that are active in diverse professions and sectors increasingly bridge public policy and corporate management fields to advance environmenEMP studies are rooted in interdisciplinary learning, global perspectives and practical application. EMP addresses both environmental policy and environmental management, grounded in the firm belief that leaders in both fields require a dual perspective. Alumni that are active in diverse professions and sectors increasingly bridge public policy and corporate management fields to advance environmen

A comparison of different orthogonal techniques for the investigation of the conformational stability of NIST mAb in liquid formulations

Antikroppar har ett brett användningsområde med stor potential men det är svårt att skapa stabila lösningar. Den strukturella stabiliteten är en viktig faktor när man väljer läkemedelskandidater, och i de tidiga utvecklingsstadierna görs prediktiva undersökningar för att ta reda på varje kandidats stabilitet och utvecklings-potential. Därmed är det av största intresse att utvärdera hur antikropparA great challenge during early development of medicinal antibodies is to determine the stability of the candidates. This is required to be able to select the candidates with the greatest developability. The stability of the candidates can be estimated using different orthogonal techniques and the aim of this investigation was thus to use orthogonal techniques for the investigation of conformationa

Fysik, Röntgen- och neutronvetenskap - Masterprogram

Masterprogrammet ger dig kunskap i hur man skapar och använder röntgenstrålar och neutronstrålar. Tack vare dessa strålars unika egenskaper kan man undersöka material inom ett brett fält av olika forskningsområden, allt från fundamentala frågeställningar inom fysik, kvantfysik och materialvetenskap till studier i biologi, geologi, medicin, arkeologi. Som student i Lund får du tillgång till två anlThe Master’s programme provides you with knowledge of how to generate and use X-rays and neutron beams. Thanks to their unique properties, they enable researchers to investigate materials in a broad range of different research fields, from fundamental issues of physics, quantum physics and materials sciences to studies in biology, geology, medicine and archaeology. As a student at Lund University,

Inhibition of coxsackie B virus infection by soluble forms of its receptors: Binding affinities, altered particle formation, and competition with cellular receptors

We previously reported that soluble decay-accelerating factor (DAF) and coxsackievirus-adenovirus receptor (CAR) blocked coxsackievirus 133 (CVB3) myocarditis in mice, but only soluble CAR blocked CVB3-mediated pancreatitis. Here, we report that the in vitro mechanisms of viral inhibition by these soluble receptors also differ. Soluble DAF inhibited virus infection through the formation of reversi

Changes in resting-state functional connectivity after stroke in a mouse brain lacking extracellular matrix components

In the brain, focal ischemia results in a local region of cell death and disruption of both local and remote functional neuronal networks. Tissue reorganization following stroke can be limited by factors such as extracellular matrix (ECM) molecules that prevent neuronal growth and synaptic plasticity. The brain's ECM plays a crucial role in network formation, development, and regeneration of the c

ICOS-ligand triggering impairs osteoclast differentiation and function in vitro and in vivo

Osteoblasts, osteocytes, and osteoclasts (OCs) are involved in the bone production and resorption, which are crucial in bone homeostasis. OC hyperactivation plays a role in the exaggerated bone resorption of diseases such as osteoporosis, rheumatoid arthritis, and osteolytic tumor metastases. This work stems from the finding that OCs can express B7h (ICOS-Ligand), which is the ligand of the ICOS T

Biologi, Allmän inriktning - Masterprogram

Tillsammans med studievägledaren utformar du en personlig studiegång. Undervisningen sker i moderna lokaler och laboratorier med avancerad utrustning. I många av kurserna utgör fältundervisning en viktig del av utbildningen. Beroende på ditt val av kurser finns därför omfattande möjligheter till kostnadsfria exkursioner och fältprojekt. Som student får du även fördjupad kunskap i försöksdesign ochYou will design your personal study route together with the study advisor. Choose from around 30 second cycle courses in Biology. Teaching takes place on modern premises and in laboratories with advanced equipment. Depending on your selection of courses, there are extensive opportunities for excursions and field projects. These are provided at no cost to the student. You will obtain specialis

Systemic sclerosis. Novel molecular and epidemiological features of disease.

Popular Abstract in Swedish Systemisk skleros (SSc) är en relativt ovanlig reumatologisk sjukdom som kan engagera många av kroppens organ. Sjukdomen kallas ibland också för sklerodermi. Typiskt för sjukdomen är att huden omvandlas till fibros och blir hård och stram över olika delar av kroppen. Typiskt för sjukdomen är också att drabbade patienter har försämrad funktion i sina blodkärl, framförallSystemic sclerosis (SSc) is a systemic rheumatic disease with significant mortality and morbidity. Different estimations of disease prevalence and incidence have been presented from various parts of the world. While lung involvement is a common cause of SSc-related death, a majority of SSc patients suffer from symptoms originating in the gastrointestinal (GI) tract. By combining data from a popu

µHDS system for desulfurization of logistic fuels for fuel cell applications

Bränsleceller är ett intressant alternativ till förbränningsmotorer då bränsleceller har en högre effektivitet, är miljövänligare samt tystare. Bränslen som diesel, bensin samt det undersökta bränslet Jet A1, innehåller olika svårreagerade svavelföreningar. Problemet med bränslena är att de har ett relativt högt svavelinnehåll. Svavelföreningarna riskerar att förgifta katalysatorerna i de nedströ