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The Minerva of the North and her medals : Iconographic strategies of Queen Christina’s reign in Sweden

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Evasion of phagocytosis through cooperation between two ligand-binding regions in Streptococcus pyogenes M protein.

The M protein of Streptococcus pyogenes is a major bacterial virulence factor that confers resistance to phagocytosis. To analyze how M protein allows evasion of phagocytosis, we used the M22 protein, which has features typical of many M proteins and has two well-characterized regions binding human plasma proteins: the hypervariable NH2-terminal region binds C4b-binding protein (C4BP), which inhib

Derivation of efficiency factors for uneven irradiation on a fin absorber

In the equation for thermal energy output from a flat-plate solar collector (written as a function of the collector mean heat carrier temperature), both the gain and the loss terms are multiplied by the collector efficiency factor, F'. For a concentrating collector with an uneven (non-uniform) irradiation on the absorber, the efficiency factor for the gain term, here called the optical efficiency

Interactions between dendritic cells and epithelial cells in allergic disease

Nanoparticle-Assisted Pool Boiling Heat Transfer on Micro-Pin-Fin Surfaces

A bispecific IgG format containing four independent antigen binding sites

Immune complex binding Streptococcus pyogenes type M12/emm12 in experimental glomerulonephritis

Positional cloning of the Igl genes controlling rheumatoid factor production and allergic bronchitis in rats

BspK, a serine protease from the predatory bacterium Bdellovibrio bacteriovorus with utility for analysis of therapeutic antibodies

The development of therapeutic and diagnostic antibodies is a rapidly growing field of research, being the fastest expanding group of products on the pharmaceutical market, and appropriate quality controls are crucial for their application. We have identified and characterized the serine protease termed BspK (Bdellovibrio serine protease K) from Bdellovibrio bacteriovorus and here show its activit

New perspectives on complement mediated immunotherapy

Tumor-specific monoclonal antibodies (mAbs) offer several modes of tumor cell killing, from direct cytotoxic activity to indirect mechanisms employing the host immune system, particularly its innate branch. The latter effector functions seem to dominate among clinically approved anti-cancer mAbs and major efforts are being undertaken by both academia and the pharmaceutical industry with the aim to

New treatments in hemophilia: insights for the clinician.

Hemophilia has evolved from an often fatal hereditary bleeding disorder to a disorder for which safe and effective treatment is available. However, there are several challenges remaining in the treatment of hemophilia. Prophylaxis to prevent bleeding is costly and requires frequent intravenous injections, which are cumbersome for patients. Venous access is often difficult to achieve, especially in