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The responses of the benthic marine dinoflagellate Prorocentrum lima to nutrient stress induced by unbalanced N:P ratios were the subject of this study. Batch cultures of P. lima cells were grown under NP sufficient (N as nitrate and ammonium) and deficient conditions, and the cell growth and toxicity were followed for eight weeks. P. lima grew slowly in all nutrient conditions and net growth rate

Aims and background: Whole-genome sequencing (WGS) is increasingly applied in clinical practice and expected to replace standard-of-care (SoC) genetic diagnostics in hematological malignancies. This study aims to assess and compare the fully burdened cost (‘micro-costing’) per patient for Swedish laboratories using WGS and SoC, respectively, in pediatric and adult patients with acute lymphoblastic

Purpose: Artifacts impacting the imaged tumor volume can be seen in conventional three-dimensional CT (3DCT) scans for planning of lung cancer radiotherapy but can be reduced with the use of respiration-correlated imaging, i.e., 4DCT or breathhold CT (BHCT) scans. The aim of this study was to compare delineated gross tumor volume (GTV) sizes in 3DCT, 4DCT, and BHCT scans of patients with lung tumo

Mantle cell lymphoma (MCL) is a B-cell malignancy currently considered incurable. Although some patients obtain prolonged remission after first-line chemoimmunotherapy, many will need several treatment lines. Here, we present a nationwide assessment of treatment strategies, time to progression and survival in MCL. All patients diagnosed with MCL 2006-2018 were identified in the Swedish Lymphoma Re

Aims: (i) Determine whether between-observer reproducibility for Ki67 when assessed on whole sections according to a standardized scoring protocol is adequate for clinical application. (ii) Compare between-observer reproducibility of Ki67 scores assessed on hot-spots to scores using a global method that averages across a tissue section.Background: The nuclear proliferation biomarker Ki67 has multi

Background: End-of-life care in the Intensive Care Unit (ICU) is complex, requiring a balance of ethical, cultural and medical considerations while ensuring comfort and dignity for critically ill patients and their families.Aim: We aimed to develop a set of core domains for end-of-life care at Scandinavian ICUs along with corresponding consensus statements from patients, families and multidiscipli

AimDespite new therapies, castration-resistant prostate cancer (CRPC) is still incurable. Intercellular Adhesion Molecule 1 (ICAM-1) is a well-characterized cell surface protein involved in prostate cancer pathogenesis, differentially expressed during transition from hormone-sensitive to CRPC. This study aimed to investigate ICAM-1 as a target for imaging and radioimmunotherapy of CRPC.MethodsAntiDespite new therapies, castration-resistant prostate cancer (CRPC) is still incurable. Intercellular Adhesion Molecule 1 (ICAM-1) is a well-characterized cell surface protein involved in prostate cancer pathogenesis, differentially expressed during transition from hormone-sensitive to CRPC. This study aimed to investigate ICAM-1 as a target for imaging and radioimmunotherapy of CRPC.Anti-ICAM-1 an

Restoring cultivated peatlands has become a silver bullet in climate change mitigation policies globally due to peatlands’ potentials to sequester carbon. In Denmark, carbon is the focal point for such interventions but simultaneously conspicuous by its absence in local restoration efforts. Scientific abstractions render carbon visible through maps and models presenting soil’s carbon content, emisRestoring cultivated peatlands has become a silver bullet in climate change mitigation policies globally due to peatlands’ potentials to sequester carbon. In Denmark, carbon is the focal point for such interventions but simultaneously conspicuous by its absence in local restoration efforts. Scientific abstractions render carbon visible through maps and models presenting soil’s carbon content, emis

The normal-like molecular subtype of breast cancer has not been well characterized and is currently not included in the clinically approved PAM50 molecular subtype classification. Tumors classified as normallike display high expression of basal epithelial genes and low expression of luminal epithelial genes, but also high expression of genes expressed by non-epithelial cell types including adipocy

Objective: To study the association between cardiovascular co-morbidities and mortality risk in primary care patients with atrial fibrillation. Methods: The study population included all adults (n = 12,283) ≥ 45 years diagnosed with AF at 75 primary care centres in Sweden between 2001 and 2007. The outcome was mortality (until 2010) and data were explored for co-morbidities using Cox regression wi

This thesis explores the relationship between news media and trust from the perspective of the individual audience member using the term “fake news” to do so. This thesis set out to understand how audiences were engaging with and defining the term “fake news” in our contemporary media environment and if and how this was affecting their overall engagement with news media. To do so, the study used a

Title: Underprissättning på den svenska marknaden - går den att förutspå? Seminar date: 2019-06-04 Course: FEKH89, Bachelor Degree Project in Financial Management, 15 ECTS Authors: Ebba Halvarsson, Erika Langåker och Sigrid Jonsson Advisor: Maria Gårdängen Keywords: Underpricing, Initial public offering, Ex ante, Nasdaq Stockholm, Nasdaq First North, Multiple regression, Asymmetric information Pur

The EU cohesion policy is a key policy area of the Union which aims for sustainable development and socioeconomic growth in the regions of the Member States. However, in the current structure of the multi-level governance system, the EU is much reliant on the capacity of the national public administrations to execute and implement the cohesion policy and thereby achieve the intended EU policy obje

Trade marks perform a variety of economic functions in a commercial environment and plays an important role in a market economy. Therefore, there is a need to protect the distinguishing of competing goods and services offered by undertakings and accordingly to avoid consumer confusion. The origin function of the trade mark guarantees that all products bearing a trade mark emanate from the same com

Popular Abstract in English Each year an estimated 530 000 new cases of cervical cancer are diagnosed and more than 275 000 women die from cervical cancer worldwide (2). Cervical cancer is caused by sexually-acquired infections with a subset of human papillomavirus (HPV) (359, 360). HPV is the most common viral infection of the anogenital tract (2). Almost all sexually active individuals will be iHuman papillomaviruses (HPVs) cause almost half of the human cancers that are attributable to viruses. HPV type 16 is the most carcinogenic type among the HPVs and is detected in 50% of all cervical cancers. HPV-16 infects epithelial cells and HPV-16 gene expression is tightly linked to the differentiation stage of the infected cells. Early HPV-16 genes are expressed in basal layers of the epithel

In Sweden as well as in The Netherlands energy policy is increasingly aiming at extending the use of renewable sources. In accordance with the targets of the European Union, both countries have formulated national targets for the year 2020. For wind energy these targets are 30.0 TWh of electricity in Sweden and a total installed capacity of 10.0 GW in The Netherlands. Wind is an inflexible, variab

Popular Abstract in English Oil resources are finite; and political and economic factors affecting oil production,together with the environmental damage associated with the increased use of oil by a rapidly growing population, have underscored the need for developing cleaner technologies based on sustainable resources. In this context, any lignocellulosic biomass that is not used in the food chainThe present work was aimed at developing industrial S. cerevisiae strains with improved tolerance to two types of stressors encountered during the fermentation of lignocellulosic biomass that affect ethanol yield and productivity, namely hydrolysate-derived inhibitors and high temperature, and at understanding the response of yeast and mechanisms of adaptation to such stressors. In one part of the

PURPOSE: To evaluate the plasma level of different forms of soluble urokinase plasminogen activator receptor (suPAR) as discriminators between malignant, borderline, and benign ovarian tumors and as prognostic markers in patients with ovarian cancer. EXPERIMENTAL DESIGN: The different suPAR forms were measured in preoperative plasma samples obtained from 335 patients with adnexal lesions using thr

Background: Following surgical repair of aortic coarctation (CoA) there is a risk for restenosis (reCoA), particularly in the first year of life. It was the aim of this study to identify reCoA risk factors by analyzing postoperative pre-discharge echocardiograms. Methods: Retrospective analysis of echocardiograms of children born operated for CoA in Sweden 2011-2017. Results: 253 children were incBackground Following surgical repair of aortic coarctation (CoA) there is a risk for restenosis (reCoA), particularly in the first year of life. It was the aim of this study to identify reCoA risk factors by analyzing postoperative pre-discharge echocardiograms. Methods Retrospective analysis of echocardiograms of children born operated for CoA in Sweden 2011-2017. Results 253 children were includ

Low-grade fibromyxoid sarcoma (LGFMS) is a distinctive fibroblastic neoplasm that is characterized by alternating collagenous and myxoid areas, deceptively bland spindle cell morphology, a whorling architecture, and a t(7;16) translocation involving FUS and CREB3L2. Owing to variable morphology and a lack of discriminatory markers, LGFMS can be difficult to distinguish from benign mesenchymal tumo