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Hospital volumes and later year of operation correlates with better outcomes in acute Type A aortic dissection

OBJECTIVES: Acute Type A aortic dissection remains a life-threatening disease, but there are indications that its surgical mortality is decreasing. The aim of this report was to study how surgical mortality has changed and what influences those changes.METHODS: Nordic Consortium for Acute Type A Aortic Dissection is a retrospective database comprising 1159 patients (mean age 61.6 ± 12.2 years, 68%

Brain injury markers in blood predict signs of hypoxic ischaemic encephalopathy on head computed tomography after cardiac arrest

Background/Aim: Signs of hypoxic ischaemic encephalopathy (HIE) on head computed tomography (CT) predicts poor neurological outcome after cardiac arrest. We explore whether levels of brain injury markers in blood could predict the likelihood of HIE on CT. Methods: Retrospective analysis of CT performed at 24–168 h post cardiac arrest on clinical indication within the Target Temperature Management

The association of partial pressures of oxygen and carbon dioxide with neurological outcome after out-of-hospital cardiac arrest : an explorative International Cardiac Arrest Registry 2.0 study

BACKGROUND: Exposure to extreme arterial partial pressures of oxygen (PaO2) and carbon dioxide (PaCO2) following the return of spontaneous circulation (ROSC) after out-of-hospital cardiac arrest (OHCA) is common and may affect neurological outcome but results of previous studies are conflicting.METHODS: Exploratory study of the International Cardiac Arrest Registry (INTCAR) 2.0 database, including

Predicting neurological outcome after out-of-hospital cardiac arrest with cumulative information; development and internal validation of an artificial neural network algorithm

Background: Prognostication of neurological outcome in patients who remain comatose after cardiac arrest resuscitation is complex. Clinical variables, as well as biomarkers of brain injury, cardiac injury, and systemic inflammation, all yield some prognostic value. We hypothesised that cumulative information obtained during the first three days of intensive care could produce a reliable model for

Internet Use and Loneliness Among Older Adults : The Moderating Role of Self-perceptions of Ageing

Loneliness in advanced age has become one of the societal concerns considering its detrimental effects on physical and mental health of older people. Information and communication technologies show the potential to prevent or tackle loneliness and social isolation among older people. Given a percentage of the older population feeling lonely, loneliness in older age has been increasingly recognized

The figure of Eros in a rare and unpublished French book hosted by the National Library of Sweden (1785-1814) : Histoire d'une puce. Between satirical fable and erotic and libertine tale

A French book relating to flea literature has recently been discovered at the National Library of Sweden in Stockholm. This article claims to be the first presentation of the work Histoire d’une puce by Louis Marie Céleste d’Aumont, Duke of Piennes (1762-1831), with the first literary analysis of its erotic content. The second half of the story is remarkable for the presence of Swedish words in th

SPAP : Soluble Human Plasma Proteoform Analysis via Acetonitrile Precipitation and Top-Down Mass Spectrometry

Advances in liquid chromatography–mass spectrometry have significantly improved proteomic analyses of human plasma. However, information at the level of intact proteoforms remains limited due to the high dynamic range of protein abundance and the complexity of post-translational modifications. To address this challenge, we introduce soluble plasma proteoform analysis via acetonitrile precipitation

Multimodal Gene Expression Deep Learning for Predicting Sentinel Lymph Node Macro-metastasis in Early Breast Cancer: Development and Validation in the SCAN-B Cohort

Background: This study evaluates deep learning (DL) using gene expression (GEX) and preoperatively available clinical data (PreopClinic) to predict sentinel lymph node macro-metastasis (SLNM), and explores their potential for guiding axillary surgery de-escalation and supporting prognostic assessment.Methods: We retrospectively included 6,836 clinically node-negative (cN0) T1-T2 patients with inva

Serum GFAP and UCH-L1 for the prediction of neurological outcome in comatose cardiac arrest patients

Objective: Neurological outcome prediction is crucial early after cardiac arrest. Serum biomarkers released from brain cells after hypoxic-ischaemic injury may aid in outcome prediction. The only serum biomarker presently recommended in the European Resuscitation Council prognostication guidelines is neuron-specific enolase (NSE), but NSE has limitations. In this study, we therefore analyzed the o

Prognostic accuracy of head computed tomography for prediction of functional outcome after out-of-hospital cardiac arrest : Rationale and design of the prospective TTM2-CT-substudy

Background: Head computed tomography (CT) is a guideline recommended method to predict functional outcome after cardiac arrest (CA), but standardized criteria for evaluation are lacking. To date, no prospective trial has systematically validated methods for diagnosing hypoxic-ischaemic encephalopathy (HIE) on CT after CA. We present a protocol for validation of pre-specified radiological criteria

Hypothermia vs Normothermia in Patients with Cardiac Arrest and Nonshockable Rhythm : A Meta-Analysis

Importance: International guidelines recommend body temperature control below 37.8 °C in unconscious patients with out-of-hospital cardiac arrest (OHCA); however, a target temperature of 33 °C might lead to better outcomes when the initial rhythm is nonshockable. Objective: To assess whether hypothermia at 33 °C increases survival and improves function when compared with controlled normothermia in

Avtal om rätten till domstolsprövning. Processuella överenskommelsers giltighet i svensk rätt

Popular Abstract in Swedish Rätten till domstolsprövning är en grundläggande rättighet som förekommer i alla demokratiska stater. Utgångspunkten är att alla har rätt att få sina tvister prövade av en domstol i ett förfarande som uppfyller vissa kvaliteter, en rättvis rättegång, och att staten har ett ansvar att tillhandahålla förutsättningar för sådana tvistlösningsförfaranden inför domstol. DäremOne of the most fundamental rights in any democratic state is the right of access to court. Every individual shall have the right to bring legal disputes before a court, in a proceeding with specifically defined characteristics, a fair trial, and the state is responsible for supplying the conditions and prerequisites to carry out this dispute resolution process in a court of law. However, this rig

Advisory Opinion: A bridge between the CLCS and the ITLOS

The purpose of this thesis is to try to establish a mechanism that will enable the Commission on the Limits of the Continental Shelf to get access to legal interpretation of the United Nations Convention on the Law of the Sea. The mandate of the Commission is to validate the outer limits line delineated by coastal States. For that, the Commission has to apply provisions of the Convention. The use

The researcher's guide to selecting biomarkers in mental health studies

Clinical mental health researchers may understandably struggle with how to incorporate biological assessments in clinical research. The options are numerous and are described in a vast and complex body of literature. Here we provide guidelines to assist mental health researchers seeking to include biological measures in their studies. Apart from a focus on behavioral outcomes as measured via inter

Regional Brain Net Water Uptake in Computed Tomography after Cardiac Arrest – A Novel Biomarker for Neuroprognostication

Background: Selective water uptake by neurons and glial cells and subsequent brain tissue oedema are key pathophysiological processes of hypoxic-ischemic encephalopathy (HIE) after cardiac arrest (CA). Although brain computed tomography (CT) is widely used to assess the severity of HIE, changes of brain radiodensity over time have not been investigated. These could be used to quantify regional bra

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Master’s Dissertation Structural Mechanics ERIK LUNDIN ADAPTIVE SYSTEMS TO REDUCE THE MATERIAL COST OF STRUCTURES Parametric Design of Adaptive Trusses DEPARTMENT OF CONSTRUCTION SCIENCES DIVISION OF STRUCTURAL MECHANICS ISRN LUTVDG/TVSM--22/5261--SE (1-62) | ISSN 0281-6679 MASTER’S DISSERTATION Supervisors: Professor KENT PERSSON, Division of Structural Mechanics, LTH and Dr ALEXANDER SEHLSTRÖM,

https://www.byggmek.lth.se/fileadmin/byggnadsmekanik/publications/tvsm5000/web5261.pdf - 2026-05-11

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https://www.folklivsarkivet.lu.se/fileadmin/user_upload/folklivsarkivet/upload/Sydow/A_641.pdf - 2026-05-11

Impact of frailty on mortality, functional outcome, and health status after out-of-hospital cardiac arrest : insights from the TTM2-trial

Purpose: To explore the association of frailty with mortality, functional outcome, and health status after out-of-hospital cardiac arrest.Methods: This is a cohort-based secondary analysis of the Targeted Hypothermia versus Targeted Normothermia after out-of-hospital cardiac arrest (TTM2) trial, an international, prospective, multicentre study. Frailty was assessed using the Clinical Frailty ScalePurpose: To explore the association of frailty with mortality, functional outcome, and health status after out-of-hospital cardiac arrest.Methods: This is a cohort-based secondary analysis of the Targeted Hypothermia versus Targeted Normothermia after out-of-hospital cardiac arrest (TTM2) trial, an international, prospective, multicentre study. Frailty was assessed using the Clinical Frailty Scale