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This chapter discusses three comparative projects that were all, at least partially, created through the replication of research across the Mistra Urban Futures cities. A typology of six possible models was developed, illustrating how comparative transdisciplinary knowledge co-production could take place across multiple cities, and the second of these approaches was identified as “local projects r

Duplicative horizontal gene transfer may bring two previously separated homologous genes together, which may raise questions about the interplay between the gene products. One such gene pair is the “native” PgiC1 and “foreign” PgiC2 in the perennial grass Festuca ovina. Both PgiC1 and PgiC2 encode cytosolic phosphoglucose isomerase, a dimeric enzyme whose proper binding is functionally essential.

Aim: To explore if electrographic status epilepticus (ESE) after cardiac arrest causes additional secondary brain injury reflected by serum levels of two novel biomarkers of brain injury: neurofilament light chain (NfL) originating from neurons and glial fibrillary acidic protein (GFAP) from glial cells. Methods: Simplified continuous EEG (cEEG) and serum levels of NfL and GFAP, sampled at 24, 48

Background Dehydroepiandrosterone (DHEA) and its sulfated ester DHEA-sulfate (DHEA-S), (together DHEA[S]), are the most abundant adrenal steroids in humans and are found in blood and the brain, where they function as neurosteroids with direct receptor affinities. Preclinical studies suggest that DHEA(S) has antidepressant/neuroprotective properties, and exogenously administered DHEA has shown anti

A housing adaptation (HA) can enable independent living in one's own home, but deciding to change the home environment can be a thought-provoking matter. The aim of this study was to explore the applicant's perspective and decision-making process when applying for an HA grant. Seventeen persons were interviewed about their application for such a grant, and the data were analyzed using a constant c

Grand challenges such as climate change put focus away from innovations and innovation policy as engines of economic growth towards fulfilling societal goals and sighting sustainable development. The literature on the geography of innovation has provided valuable insights on innovation activities of firms and industries and how they are positively influenced by co-location. In particular, short ge

BackgroundPeople with intellectual disability have been found to have higher prevalence of psychiatric disorders than the general population. However, they do not seem to have a corresponding increase in psychiatric care utilization. The aim of the present study was to investigate psychiatric care utilization among older people with intellectual disability.MethodsWe used a cohort of people with in

To reduce greenhouse gas (GHG) emissions and help mitigate climate change, urban water systems need to be adapted so that electrical energy use is minimised. In this study, energy data from 2011 was used to quantify energy use in China’s urban water supply sector. The objective was to calculate the energy co-benefits of urban water conservation policies and compare energy use between China and oth

In the course of 2000s, the region of Campania in southern Italy and its capital city Naples became global icons of waste mismanagement after the images of piles of rubbish occluding their urban areas hit the headlines. Conventional explanations, in Italy and elsewhere, pointed to administrative failure, cultural backwardness and mafia infiltration as the main causes of waste mishandling. In the s

Structural technologies are an essential component in the design of precision therapeutics. Precision medicine entails the development of therapeutics directed toward a designated target protein, with the goal to deliver the right drug to the right patient at the right time. In the field of oncology, protein structural variants are often associated with oncogenic potential. In a previous proteogen

I review formation channels for blue stragglers. I consider how they may be produced via collisions between two single main-sequence stars, or via collisions during encounters involving binary stars. Further, I discuss how blue stragglers may be produced via the evolution of isolated binaries. Observations of globular clusters suggest that both mechanisms are contributing.

Känslors roll i vår relation till skönlitteratur är ett snabbt växande forskningsfält alltsedan « the affective turn » i början av 2000-talet, bl.a. tack vare forskare som Suzanne Keen (2007), Martha Nussbaum (2001), Jenefer Robinson (2005) och Jean-François Vernay (2013), även om man fortfarande inte vet mycket om verkliga läsares känslor. Ändå har affekter, emotioner och känslor inte alls en sj

The 2010 population and housing census in Ghana revealed that more than half of the Ghanaian population lived in urban centers. Critical to the phenomenon of urbanization is the question of how to sustainably feed the urban population especially the urban poor as rapid urbanization has the tendency to urbanize poverty. This has led to renewed policy debate about the implications of farming in citi

GABA is the major inhibitory neurotransmitter in the CNS and changes in GABAergic neurotransmission affect the overall activity of neuronal networks. The uptake of GABA into synaptic vesicles is mediated by the vesicular GABA transporter (VGAT), and changes in the expression of the transporter directly regulate neurotransmitter release. In this work we investigated the changes in VGAT protein leve

Mucosal surfaces of the reproductive tract as well as their secretions have important roles in preventing sexual transmission of HIV-1. In the current study, the majority of the intrinsic anti-HIV-1 activity of human seminal plasma (SP) was determined to reside in the cationic polypeptide fraction. Antiviral assays utilizing luciferase reporter cells and lymphocytic cells revealed the ability of w

Aviation fuel is a petroleum product that fulfills the Standard Specification for Aviation Turbine Fuels. Crude oil has been the raw material for production of aviation fuels for many years. Since the availability of crude oil is predicted to be limited in the future, alternative raw materials for aviation fuels are highly desirable. A Swedish company, Oroboros AB, has developed a novel clean synt