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Popular Abstract in Swedish Identifiering av ärftlig äggstockscancer har stor klinisk relevans för att förhindra nya tumörer hos individen och i familjen. Möjligheten att förhindra bröstcancer i BRCA familjer genom kontrollprogram och profylaktisk kirurgi är välkänd, medan möjligheten att förhindra tarmcancer och livmodercancer i HNPCC familjer är mindre känd. Studierna i denna avhandling har kunnOvarian cancer is a leading cause of gynecological cancer death and in Sweden nearly 700 cases are diagnosed annually. Ovarian cancer has one of the highest frequencies of hereditary cancer. This thesis focuses on estimates of the contribution of hereditary breast and ovarian cancer (HBOC) and hereditary nonpolyposis colorectal cancer (HNPCC) to the development of ovarian cancer and investigates t

Popular Abstract in English Every level of human existence is affected by forced migration. It affects the central aspects of our outer and inner life. However, scientific research focused on the inner life of forced migrants, in particular the one regarding the impacts of forced migration on the most significant values that we hold in life, is often marginalized in forced migration studies. In anUntil recently studies regarding the pathological aspects of refugee experiences have led the psychology field of forced migration, giving little space to positive factors like the resilience and well-being of individuals faced with these adversities. This doctoral thesis emphasizes good health rather than disease and aims at deepening the understanding of resilience and health as opposed to the d

A diabetic foot ulcer (DFU) is a common and serious complication of diabetes. It is today the leading cause of amputations and is associated with both increased morbidity and mortality. Individuals with DFU have 2.5 times higher mortality rates compared to patients with diabetes but without DFU, a risk that persists even after ulcer healing. Macrovascular complications, such as a higher burden of A diabetic foot ulcer (DFU) is a common and serious complication of diabetes. It is today the leading cause of amputations and is associated with both increased morbidity and mortality. Individuals with DFU have 2.5 times higher mortality rates compared to patients with diabetes but without DFU, a risk that persists even after ulcer healing. Macrovascular complications, such as a higher burden of

Osteoclasts are derived from hematopoietic stem cells (HSCs) and form upon stimulation of osteoclast precursors by macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor κΒ ligand (RANKL). Osteoclasts resorb bone by secreting hydrochloric acid, matrix metalloproteinases (MMPs) and cathepsin K. Failure of bone resorption or bone formation results in metabolic bone disOsteoclasts are derived from hematopoietic stem cells (HSCs) and form upon stimulation of osteoclast precursors by macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor κΒ ligand (RANKL). Osteoclasts resorb bone by secreting hydrochloric acid, matrix metalloproteinases (MMPs) and cathepsin K. Failure of bone resorption or bone formation results in metabolic bone dis

The signaling within and between cells in biology is governed by molecular recognition between natural or synthetic ligands and proteins. This thesis project aimed to investigate the thermodynamic properties of specific interaction between synthetic ligands and galectin proteins. The choice of galectins as model proteins resides in the availability of applicability in a full range of complementary

All animals and some bacteria can synthesize linear polysaccharides with a backbone of repeating disaccharideunits, called glycosaminoglycans (GAGs). The GAGs are either attached to a protein core, as in proteoglycans (PGs), or exist as free polymer chains, as in hyaluronan. One of the most common types of GAGs is chondroitin/dermatan sulfate (CS/DS), where the repeating disaccharide backbone consAll animals and some bacteria can synthesize linear polysaccharides with a backbone of repeating disaccharideunits, called glycosaminoglycans (GAGs). The GAGs are either attached to a protein core, as in proteoglycans (PGs), or exist as free polymer chains, as in hyaluronan. One of the most common types of GAGs is chondroitin/dermatan sulfate (CS/DS), where the repeating disaccharide backbone cons

Trots tydlig rättspraxis och en stark politisk vilja att säkra rätten för varje enskild eller företag som lidit skada vid brott mot EU:s konkurrensregler – i synnerhet artiklarna 101 och 102 Fördraget om Europeiska unionens funktionssätt (EUF) - att kunna söka kompensation, så har det konkurrensrättsliga skadeståndet inte fått något större genomslag. Europakommissionen (”Kommissionen”) har med andDespite the clear view of the European Commission (“the Commission”) and the European Court of Justice (“the ECJ”) that any citizen or business suffering harm following a breach of the EU competition rules - in particular Articles 101 and 102 of the Treaty of the Functioning of the European Market (TFEU) - should be able to obtain damages from the infringing party, to this date, damages have only

Det är svårt att stifta en konkurrenslag som effektivt motverkar karteller samtidigt som den tar tillvara företagens rätt till en rättvis rättegång. Vårt samhälle är idag präglat av en marknadsekonomi som är i behov av en välfungerande konkurrens. Karteller är kostsamma för samhället och ytterst för samhällsmedborgarna. Det finns betydande incitament för företag att samarbeta konkurrensbegränsande

Blad 1 - csv-oskarhanss-set csv-oskarhanss-set PMID Title Authors Citation First Author Journal/Book Publication Year Create Date PMCID NIHMS ID DOI 33589841 Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture Chia R, Sabir MS, Bandres-Ciga S, Saez-Atienzar S, Reynolds RH, Gustavsson E, Walton RL, Ahmed S, Viollet C,

https://www.multipark.lu.se/sites/multipark.lu.se/files/2021-10/Publications_MemoryClinic_Platform.xlsx - 2026-05-23

How we behave in daily life has an impact on environmental emergencies. In the decisions that we take every day, decisions that are important for the climate, the built environment has a vital but not so noticed part. The project Urban design and everyday life choices recognises the built environment as a co-producer of climate ethics. One of the project studies focuses on everyday choices regardi

SyfteMålsättningen med denna studie var dels att säkerställa att tågpersonalen inte utsätts för höga halter av partiklar i sitt arbete på X60B fordon som trafikerar Arlanda. Syftet var även att ta fram ett förhållande mellan partikelnivåerna i tunnelmiljö och ombord på pendeltågsfordon av typ X60B i förarhytterna för att avgöra ventilationsfiltrets kapacitet. Kunskapen om filtreringseffektiviteten

Looking into the topic of cloud sourcing, at first glance it might be seen as an off the shelf pay per use service that is easy and fast to adopt for most companies. Although in practice not all companies succeed with cloud sourcing. Previous research shows that cloud sourcing entails risks especially in the adoption phase in terms of security, trust, data loss, and transparency among others. The

BackgroundViolence is a major public health concern with a significant impact on the health and well-being of individuals, families, and communities. Living in a new environment without parental control and experimenting with new lifestyles may increase the risk of violence among university students. Therefore, this study aimed to assess exposure to violence and its associated factors among univerBackgroundViolence is a major public health concern with a significant impact on the health and well-being of individuals, families, and communities. Living in a new environment without parental control and experimenting with new lifestyles may increase the risk of violence among university students. Therefore, this study aimed to assess exposure to violence and its associated factors among univer

Background and purposeUncertainty and changeability often characterize the cases that come to the attention of social services and are also something that social workers to some degrees are trained to deal with. However, while the organizational complexity affecting the decision-making process is described to increase, scholars in organization studies argue that as pressures increase and resources

This paper challenges the dominant conceptualization of authentic self-presentation as real, genuine or true expression of inner essence or social identity (Lehmann et al., 2019) and calls for its redefinition in light of the rise of AI-generated content within algorithmically mediated online environments. Authenticity has long been central to identity construction and self-presentation, tradition

Popular Abstract in Danish Genterapi er en attraktiv terapiform mod neurologiske lidelser som Parkinsons sygdom og epilepsi af flere grunde. Gener med en terapeutisk effekt kan introduceres lokalt ved præcise injektioner i det syge væv, hvor genproduktet kan frigives fra nerveceller i respons til aktivitet i det omgivende væv. Ved genterapi omgås den forhindring som blod-hjernebarrieren udgør, ligGene therapy is an attractive strategy for neurological disorders, such as Parkinson’s disease and epilepsy, for several reasons. Introduction of genes with a therapeutic potential can be achieved locally, by accurate injections in the compromised tissue, and release of a transgene therapeutic substance can be regulated by the surrounding host neural circuitry. The gene therapy approach circumvent

The book has two interrelated objectives. One objective is meta-theoretical and concerns the exploration of theoretical debates connected to issues of studying society and environmental problems; another objective is empirical/analytical, referring to the analysis of "green" public participation in the electricity and waste sectors in Sweden, and partly in the Netherlands as well as the UK. The me

Transaktionsanalytisk psykoterapi - Tre metoder som beskriver en transaktionsanalytisk gruppterapi Avhandlingen är baserad på en ett årig Transaktionsanalytisk gruppterapi. Transaktionsana-lysen (TA) är en integrerad, relationell psykodynamisk terapi med rötter i den humanistiska psykologin. Den beskrivs i den internationella TA föreningen, ITAA:s utbildningsmanual (ITAA hemsida, 2011) som "en peTransactional Analysis Psychotherapy - Three Methods Describing a Transactional Analysis Group Therapy The overall aim of the present thesis was to enhance and revive the practical understanding of the active ingredients in Transactional Analysis Psychotherapy (TA) and to define and lay down elements of TA, which makes it a distinct and replicable method of treatment. The thesis includes three em