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Artikeln återger författarens föreläsning vid installationen som professor i offentlig rätt vid juridiska fakulteten vid Lunds universitet i oktober 2018. Föreläsningen uppmärksammar de indelningar och specialiseringar som förekommer i juridiken,och då särskild offentlig rätt. Avsikten är att uppmärksamma frågan varför man överhuvudtaget ska tala om offentlig rätt och varför man ska ägna sig åt de

BACKGROUND: There is little consensus on a standard approach to analysing bone scan images. The Bone Scan Index (BSI) is predictive of survival in patients with progressive prostate cancer (PCa), but the popularity of this metric is hampered by the tedium of the manual calculation. OBJECTIVE: Develop a fully automated method of quantifying the BSI and determining the clinical value of automated

The genetic mechanisms underlying the expansion in size and complexity of the human brain remain poorly understood. Long interspersed nuclear element-1 (L1) retrotransposons are a source of divergent genetic information in hominoid genomes, but their importance in physiological functions and their contribution to human brain evolution are largely unknown. Using multiomics profiling, we here demons

Acute myeloid leukemia (AML) is initiated and propagated by leukemia stem cells (LSCs), a self-renewing population of leukemia cells responsible for therapy resistance. Hence, there is an urgent need to identify new therapeutic opportunities targeting LSCs. Here, we performed an in vivo CRISPR knockout screen to identify potential therapeutic targets by interrogating cell surface dependencies of L

Företag marknadsför över 200 mjukvaror för artificiell intelligens (AI) inom radiologi.Vårdgivare behöver ha möjlighet till opartisk och kvalitetssäkrad utvärdering.Projektet Validering av AI inom bröst­radio­­­logi (VAI-B) startades för att möta detta behov, initialt inom mammografi­screening.

A significant problem in diffusion MRI (dMRI) is the lack of understanding regarding which microstructural features account for the variability in the diffusion tensor imaging (DTI) parameters observed in meningioma tumors. A common assumption is that mean diffusivity (MD) and fractional anisotropy (FA) from DTI are inversely proportional to cell density and proportional to tissue anisotropy, resp

As a major buyer of steel, the construction sector is uniquely positioned to advance the decarbonization of global steel through increasing the demand for green steel. To unlock this potential, deepened international collaborations on green public procurement, climate policies, and trade are needed.

B-cell progenitor acute lymphoblastic leukemia (BCP-ALL) is the most common childhood malignancy and is driven by multiple genetic alterations that cause maturation arrest and accumulation of abnormal progenitor B cells. Current treatment protocols with chemotherapy have led to favorable outcomes but are associated with significant toxicity and risk of side effects, highlighting the necessity for

Aims Invariant natural killer T (iNKT) cells, a T cell subset that is CD1d-restricted and expresses a semi-invariant T cell receptor, have been proposed to contribute to dyslipidaemia-driven cardiovascular disease due to their ability to specifically recognize lipid antigens. Studies in mice have attributed pro-atherogenic properties to iNKT cells, but studies in humans investigating associations

Background: Early detection of treatment response is important for the management of patients with malignant brain tumors such as glioblastoma to assure good quality of life in relation to therapeutic efficacy. Aim: To investigate whether parametric response mapping (PRM) with diffusion MRI may provide prognostic information at an early stage of standard therapy for glioblastoma. Materials and met

Background: Dyslipidaemia in patients with diabetes contributes to the risk of atherosclerotic cardiovascular disease. We aimed to identify a dyslipidemic profile associated with both dysglycemia and subclinical coronary atherosclerosis. Methods: Study participants (n = 5050) were classified in three groups: normoglycemia, pre-diabetes, and diabetes. A coronary artery calcium score (CACS) > 0 defi

Banverket äger och förvaltar ett stort antal tunnlar samtidigt som planering och byggande pågår för ett flertal tunnlar. Syftet med föreliggande arbete är att öka kunskapen och på sikt förbättra och förenkla processen angående personsäkerhet i tunnlar. Rapporten beskriver det inventeringsarbete som utförts med avseende på både befintliga och nya tunnlar med fokus på personsäkerhet...

Long interspersed nuclear element 1 (L1) retrotransposons represent a vast source of genetic variability. However, mechanistic analysis of whether and how L1s contribute to human developmental programs is lacking, in part due to the challenges associated with specific profiling and manipulation of human L1 expression. Here, we show that thousands of hominoid-specific L1 integrants are expressed in

Introduction Parkinson’s disease (PD) is a common neurodegenerative disease, which has extensive pathology that critically includes the loss of midbrain dopaminergic neurons. This loss leads to debilitating motor features such as bradykinesia and rigidity, as well as some non-motor symptoms. Intracerebral dopamine cell transplants have been explored for many years as a new approach to treating PD

The reassignment technique is used to increase localization for signal components in the time-frequency representation. The technique gives perfect localization for linear chirp signals and constant frequency signals. Despite the recent interest in using the reassignment technique to determine phase-shifts, no general expression of cross-spectrogram reassignment vectors exists. This submission aim