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Risk of Stroke in Patients With Atrial Fibrillation Is Associated With Stroke in Siblings : A Nationwide Study

Background: It remains unclear whether heritable factors can contribute to risk stratification for ischemic stroke in patients with atrial fibrillation (AF). We examined whether having a sibling with ischemic stroke was associated with increased risk of ischemic stroke and mortality in patients with AF. Methods and Results: In this nationwide study of the Swedish population, patients with AF and t

Cartilage oligomeric matrix protein promotes prostate cancer progression by enhancing invasion and disrupting intracellular calcium homeostasis

Cartilage oligomeric matrix protein (COMP) was recently implicated in the progression of breast cancer. Immunostaining of 342 prostate cancer specimens in tissue microarrays showed that COMP expression is not breast cancer-specific but also occurs in prostate cancer. The expression of COMP in prostate cancer cells correlated with a more aggressive disease with faster recurrence. Subcutaneous xenog

Genetic interaction analysis among oncogenesis-related genes revealed novel genes and networks in lung cancer development

The development of cancer is driven by the accumulation of many oncogenesis-related genetic alterations and tumorigenesis is triggered by complex networks of involved genes rather than independent actions. To explore the epistasis existing among oncogenesis-related genes in lung cancer development, we conducted pairwise genetic interaction analyses among 35,031 SNPs from 2027 oncogenesis-related g

A Phenotypic Screening Assay Identifies Modulators of Diamond Blackfan Anemia

Diamond-Blackfan anemia (DBA) is a bone marrow failure syndrome caused by mutations in ribosomal protein genes. Pathogenic mechanisms are poorly understood but involve severely reduced proliferation of erythroid precursors. Because current DBA therapies are ineffective and associated with severe side effects, disease-specific therapies are urgently needed. We hypothesized that druggable molecular

Multivoxel 1H MR spectroscopy biometrics for preoprerative differentiation between brain tumors

Purpose To investigate multivoxel proton Magnetic Resonance Spectroscopy (1HMRS) biometrics for preoperative differentiation and prognosis of patients with brain metastases (MET), low-(LGG) and high grade glioma (HGG). Methods Thirty-five patients (15 HGG, 9 LGG and 11 MET) were included. Proton Magnetic Resonance Spectroscopy Imaging(1H-MRSI) data was assessed and neurochemical profiles for metab

Sömnstörningar hos barn

Som ett led i regeringsuppdraget att ”Utvidga kunskapen om barns läkemedel och deras användning” anordnade Läkemedelsverket 2012 ett möte med representanter för barn- och ungdomspsykiatrin. Syftet var att identifiera kunskapsluckor samt föreslå speciella läkemedelsområden där det fanns behov av att sammanställa kunskap. Behandling av sömnstörningar hos barn var ett område som prioriterades.

Eosinophil Cationic Protein, Carotid Plaque, and Incidence of Stroke

BACKGROUND AND PURPOSE: ECP (eosinophil cationic protein) is a marker of eosinophil activity and degranulation, which has been linked to atherosclerosis and cardiovascular disease. We examined the relationship between ECP, carotid plaque, and incidence of stroke in a prospective population-based cohort.METHODS: The subjects participated in the Malmö Diet and Cancer Study between 1991 and 1994. A t

Functional characterization of a multi-cancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF148

Genome wide association studies (GWAS) have mapped multiple independent cancer susceptibility loci to chr5p15.33. Here, we show that fine-mapping of pancreatic and testicular cancer GWAS within one of these loci (Region 2 in CLPTM1L) focuses the signal to nine highly correlated SNPs. Of these, rs36115365-C associated with increased pancreatic and testicular but decreased lung cancer and melanoma r

Profiling of the plasma proteome across different stages of human heart failure

Heart failure (HF) is a major public health problem characterized by inability of the heart to maintain sufficient output of blood. The systematic characterization of circulating proteins across different stages of HF may provide pathophysiological insights and identify therapeutic targets. Here we report application of aptamer-based proteomics to identify proteins associated with prospective HF i

The relationship between blood pressure and risk of renal cell carcinoma

BACKGROUND: The relation between blood pressure and kidney cancer risk is well established but complex and different study designs have reported discrepant findings on the relative importance of diastolic blood pressure (DBP) and systolic blood pressure (SBP). In this study, we sought to describe the temporal relation between diastolic and SBP with renal cell carcinoma (RCC) risk in detail.METHODS

Direct observation of secondary nucleation along the fibril surface of the amyloid β 42 peptide

Alzheimer's disease is a neurodegenerative condition which involves heavy neuronal cell death linked to oligomers formed during the aggregation process of the amyloid β peptide 42 (Aβ42). The aggregation of Aβ42 involves both primary and secondary nucleation. Secondary nucleation dominates the generation of oligomers and involves the formation of new aggregates from monomers on catalytic fibril su

Bulk Acoustic Wave Activated Droplet Generation and Isolation

On-demand droplet generation from a continuously flowing stream of aqueous phase has profound applications in dropletbased microfluidics for rare event encapsulation studies. Here, we present acoustic relocation-based droplet generation from co-flowing immiscible fluids in an on-demand manner using bulk acoustic wave (BAW). After on-demand droplet generation, droplets are isolated using the same a

Apprenticeship training in Sweden

Apprenticeship training in Sweden and many other European countries goes back to the middle ages. Yet, this special model of vocational education still attracts significant interest due to the challenges young people face in preparing to enter the current labour market. This is obvious both in Sweden and in other comparable countries. The apprenticeship model is primarily promoted as achieving twoApprenticeship training in Sweden and many other European countries goes back to the middle ages. Yet, this special model of vocational education still attracts significant interest due to the challenges young people face in preparing to enter the current labour market. This is obvious both in Sweden and in other comparable countries. The apprenticeship model is primarily promoted as achieving two

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Humanistiska och teologiska fakulteterna GRUNDUTBILDNINGSINTERNAT | 11-12 JUNI 2020 | DIGITALT VIA ZOOM MINNESANTECKNINGAR | MANUELA ROSSING Innehåll DAG 1 UPPFÖLJNING AV KVALITETSARBETET 2019: EXAMENSMÅL OCH MÅLUPPFYLLELSE STUDENTERS REFLEKTIONSARBETE................................................................................. 3 Kamratgranskning, formativ bedömning, återkoppling och tröskelbe

https://www.ht.lu.se/fileadmin/user_upload/ht/dokument/Fakulteterna/GUN/Grundutbildningsinternat_2020_minnesanteckningar_slutversion.pdf - 2026-05-21

Villarreal georgina thesis 2010

Portada Research for Sustainability - An analysis of key factors supporting strategic decision-making - Thesis Supervisor Author Carl Dalhammar, PhD Georgina Villarreal Herrera International Institute for Industrial LUMES Environmental Economics ginavillarreal@gmail.com carl.dalhammar@iiiee.lu.se Lund University Centre for Sustainability Studies, LUCSUS Geocentrum 1, Solvegatan 10 P.O. Box 170, SE

https://www.lumes.lu.se/sites/lumes.lu.se/files/villarreal_georgina_thesis_2010.pdf - 2026-05-22

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Research Seminar in Theology, Philosophy and Ethics Spring 2024 Centrum för t eo log i och r e l ig ionsvet enskap Time: Tuesdays at 16.15-18.00 (unless otherwise stated). Venue: LUX B417 or Zoom (none of the seminars are hybrid unless otherwise stated before the event) 30 Jan JS Joint Seminar with Global Christianity & Interreligious Relations: Presentations by Ulrich Schmiedel and Vera la Mela 6

https://www.ctr.lu.se/fileadmin/user_upload/ctr/pdf/forskarseminarier/f-sem-vt24/Research_Seminar_in_Theology__Philosophy_and_Ethics_Spring_2024.pdf - 2026-05-18