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Objectives: Experimental and small human studies have indicated that high total adiponectin levels have beneficial cardiometabolic effects. In contrast, however, high total adiponectin levels are also associated with higher all-cause and cardiovascular mortality in thoroughly adjusted epidemiological studies. To gain further insight into these seemingly contradictory results, we report results on

Objective: The antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides are heterogeneous disorders. The aim of this study was to identify and characterize subgroups of patients based on sex, ANCA, age at diagnosis, and organ involvement. Methods: In total, 1,167 patients with granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA) were retrospectively recruited to the s

The central hallmark of Parkinson's disease pathology is the aggregation of the α-synuclein protein, which, in its healthy form, is associated with lipid membranes. Purified monomeric α-synuclein is relatively stable in vitro, but its aggregation can be triggered by the presence of lipid vesicles. Despite this central importance of lipids in the context of α-synuclein aggregation, their detailed m

BACKGROUND: An increasing number of monogenic conditions underlying stroke are being identified. We explored the possibilities of increasing the diagnostic yield of monogenic stroke in a population under 56 years of age. METHODS: Fifty probands ≤55 years at their first stroke episode were characterized clinically and investigated by whole genome sequencing. Probands had one or more of: (1) one or

BACKGROUND: Hexavalent chromium (Cr(Ⅵ)) is classified as a group 1 human carcinogen and increases the risk of lung cancer. Non-coding RNAs (ncRNAs) have key regulatory roles in lung cancer, but less is known about their relation to Cr(Ⅵ) exposure.OBJECTIVES: We aimed to 1) measure the expression of lung cancer-related circulating ncRNAs in exposed workers and controls; 2) assess associations betwe

The concentrations of gas-phase potassium hydroxide (KOH), potassium chloride (KCl) and atomic potassium (K(g)) were quantitatively measured from the near-surface to downstream area of burning pinewood pellets by a newly developed photofragmentation tunable diode laser absorption spectroscopy (PF-TDLAS) technique to reveal the original form of the released potassium. The novel arrangement of the P

Cancer of unknown primary (CUP) is a heterogeneous syndrome diagnosed at metastatic sites. The etiology is unknown but immune dysfunction may be a contributing factor. Patients with autoimmune diseases were identified from the Swedish Hospital Discharge Register and linked to the Swedish Cancer Registry. Standardized incidence ratios (SIRs) were calculated for subsequent CUP and compared with subj

AimTo explore the meaning of lived experiences of women with a hereditary risk of breast cancer who participate in surveillance of their breasts with magnetic resonance imaging.DesignHermeneutic phenomenology.MethodsInterviews on two occasions were made with 14 women in the surveillance programme. The verbatim transcripts were analysed according to van Manen. The analysis was an insightful iterati

Understanding metabolic processes of soil fungi is essential for elucidating their ecological roles in biogeochemical cycles and responses to emergent environmental stressors. Here, we demonstrate the potential of using stable isotope probing Raman (SIP-Raman) microspectroscopy in microfluidics technology-based soil chips to trace glucose metabolism rates and stress responses in laboratory grown f

The optical response of gold-silver (Au-Ag) alloy nanoparticles is strongly influenced by their localized surface plasmon resonance (LSPR), which can be tuned by varying the particle composition. Accurate simulation of LSPR, often performed using Mie theory, critically depends on the choice of dielectric function, yet available datasets for gold, silver, and their alloys vary widely. In this work,

We report a radical extension of magnetic-resonance spectroscopy to the Terahertz (THz) spectral range by complete polarization-resolved measurement of the linear electromagnetic response of nuclear and electron spin associated magnetic resonance using principles of ellipsometry at high magnetic fields. This new method permits us to accurately test existing models and leads to discovery of new phy

We determine the composition dependence of the below-bandgap anisotropic refractive indices and dielectric functions of β-(AlxGa1−x )2O3 for x up to 25% Al. We use Mueller matrix generalized spectroscopic ellipsometry and investigate a set of high quality single crystalline bulk (x = 0 %, 5 %, 10 %, 15 %, 20 %, 25 %) and thin film (4.6%, 9.7%, 12%, 15%, 16.3%, 21%) samples grown by the Czochralski

Vision provides important sensory input to postural control. Medical conditions and aging affect sensory—Central Nervous System (CNS) interactions, causing mismatches. Virtual Reality (VR) may address these by promoting recalibration from vision to other systems. Twenty-eight young adults (17 males, mean age 25.3 years) and 25 older adults (14 males, mean age 74.8 years) were included. Electromyog

Ni1+δSn (δ = 0.2, 0.4) and Ni1+δ(In/Sb) (δ = 0.1–0.5) (NiAs/Ni2In type) were synthesized, and their crystal structures were studied in this report. In Ni1+δ(In/Sb), the excess nickel atoms (δ = 0.1–0.5) occupy the vacant trigonal bipyramidal interstitial sites in the NiAs-type structural arrangement, leading to the evolution of a fully disordered to ordered superstructure through a series of incom

A detailed understanding of excited-state evolution is critical to realizing the full potential of abundant-metal coordination complex photosensitizers. Here, we show how wide-band optical transient absorption spectroscopy (oTA) can delineate the complete energy relaxation pathway of the photoexcited state of Fe(ii) polypyridyl complexes supported by benzannulated diarylamido ligands. By covering

Time-resolved imaging of plasmonic near fields is well-established at visible wavelengths but remains largely unexplored in the short-wavelength infrared (SWIR) range. Here, we use time-resolved photoemission electron microscopy (TR-PEEM) to directly visualize ultrafast plasmon dynamics in silver nanowires driven by a few-cycle SWIR pulses. We observe strong electric-field enhancement localized at

Extracellular matrix, either produced by cancer cells or by cancer-associated fibroblasts, influences angiogenesis, invasion and metastasis. Chondroitin/dermatan sulfate (CS/DS) proteoglycans, which occur both in the matrix and at the cell surface, play important roles in these processes. The unique feature that distinguishes DS from CS is the presence of iduronic acid (IdoA) in DS. Here, we repor