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Lung Fibroblasts from Chronic Obstructive Pulmonary Disease Subjects Have a Deficient Gene Expression Response to Cigarette Smoke Extract Compared to Healthy
BACKGROUND AND AIM: Cigarette smoking is the most common cause of chronic obstructive pulmonary disease (COPD) but more mechanistic studies are needed. Cigarette smoke extract (CSE) can elicit a strong response in many COPD-related cell types, but no studies have been performed in lung fibroblasts. Therefore, we aimed to investigate the effect of CSE on gene expression in lung fibroblasts from hea
Relationship Between Active Aging and Perceived Aspects of Home Among Persons Aged 55+ Listed With an Interest in Relocation
The objectives of this study were to explore active aging among people listed with an interest in relocation, and the relationships between active aging and aspects of perceived home. Using cross-sectional data from the 2022 RELOC-AGE project ( N = 1,509, mean age = 70 years), linear regression analysis was conducted. Women and individuals with higher self-rated health and education reported highe
Accurate genotype-based demultiplexing of single cell RNA sequencing samples from non-human animals
Single cell sequencing technologies (scRNA-seq, scATAC-seq, etc.) have revolutionized the study of complex tissues and unique organisms, providing researchers with a much needed species agnostic tool to study biological processes at the cellular level. To date, scRNA-seq technologies are expensive, require sufficient cell quantities, and need biological replicates to avoid batch effects or artifac
Prdm16 amplifies Notch signaling and suppresses venous lineage specification to prevent arteriovenous malformations during vascular development
Proper arterial versus venous endothelial lineage identity is required to establish a hierarchical network of arteries and veins and prevent the occurrence of life-threatening arteriovenous malformations. The molecular mechanisms that govern arteriovenous lineage specification remain however incompletely understood. Here, we demonstrate that the transcription factor Prdm16 is expressed in arterial
Sequencing and chromosome-scale assembly of the giant Pleurodeles waltl genome
The Iberian ribbed newt (Pleurodeles waltl) constitutes a central model for probing the basis of vertebrate regeneration. Here, we present the sequencing and chromosome-scale assembly of the 20.3Gb P. waltl genome, which exhibits the highest level of contiguity and completeness among giant genome assemblies. We uncover that DNA transposable elements are the major contributors to its expansion, wit
Access of medication review for people living with dementia : An analysis of inequality using Swedish register data
INTRODUCTIONThis study examines medication reviews (MRs) among people living with dementia (PWD) in Sweden, focusing on frequency and factors influencing access.METHODSUsing nationwide register data, all diagnosed PWD from 2010 to 2016 were assessed for MR receipt in 2015 and/or 2016. The analysis guided by the Andersen healthcare utilization framework, considered predisposing, enabling, and need-
Antisecretory factor as add-on treatment for newly diagnosed glioblastoma, IDH wildtype : study protocol for a randomized double-blind placebo-controlled trial
Background: Glioblastoma, IDH wildtype is the most common primary malignant brain tumor in adults. Despite best available treatment, prognosis remains poor. Current standard therapy consists of surgical tumor removal followed by radiotherapy and chemotherapy with the alkylating agent temozolomide. Antisecretory factor (AF), an endogenous protein, may potentiate the effect of temozolomide and allev
Transient AlH distribution around a burning micron-sized Al droplet quantified by laser absorption imaging
This study presents the first direct measurement of aluminum monohydride (AlH) distribution and dynamics during aluminum combustion. Single micron-sized aluminum droplets were burned in a controlled H₂O/N₂/O₂ environment to ensure repeatable conditions. A dual-wavelength laser absorption imaging system is used to quantify the AlH concentration with high temporal and spatial resolution. The results
H2-K1 protects murine MLL-AF9 leukemia stem cells from natural killer cell-mediated immune surveillance
Acoustic Nanoparticle Trapping Is Driven by Synergy between Acoustic and Hydrodynamic Interactions
Acoustic forces occurring in resonant microfluidic chambers allow the handling of micrometer-sized particles. Trapping of nanoparticles has been shown for high particle concentrations and after preseeding the chamber with larger particles. We show that the trapping mechanism is due to synergy between hydrodynamic shielding and acoustic forces. Acoustic interactions are significant only when seed p
From Nuclear Transplantation to Cellular Reprogramming—A Scientist Who Transformed Our View of Cell Identity
RWI Afghanistan Programme Research Fellows: Activities Update, Autumn 2024 - The Raoul Wallenberg In
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Nothing but NETs : Cytokine adsorption correlates with lower circulating nucleosomes and is associated with decreased primary graft dysfunction
Elevated levels of neutrophil extracellular traps (NETs) have been reported in primary graft dysfunction, making methods to reduce or remove them highly valuable. The mechanisms behind primary graft dysfunction remain rudimentarily understood but its relation to higher rates of acute and chronic rejection necessitates the development of preventative treatments. This case series explores the use of
Så håller sig fåglarna svala i värmen
Strupfladder och flämtandning är några av tricken som fåglar tar till för att överleva höga temperaturer. I en allt varmare framtid kanske det inte räcker, skriver fågelforskarna Andreas Nord och Susan J. Cunningham.
Physicochemical properties of root fiber suspensions. A comparison between parsnip (Pastinaca sativa) and yacon (Smallanthus sonchifolius)
The physicochemical properties of two root suspensions, parsnip (Pastinaca sativa) and yacon (Smallanthus sonchifolius), were studied and compared at different concentrations and after being subjected to processes such as homogenization and heating. The study and the evaluation of the physicochemical properties of these plant materials in the form of pastes might help to increase the interest in t
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INNEHÅLL RAPPORTER 3 Collegium Patristicum Lundense & Den patristiska dagen 2003 3 Incontro di Studiosi dell’Antichità Cristiana 6–8 maggio 2004 4 Nordiskt nätverk om antik kristendom 4 Religion und Rhetorik 4 Symposium Byzantino-Nordicum 5 Partakers of the Divine Nature: Deification 6 The 10th International Congress on St Gregory of Nyssa PLANERAT 7 Patristisk dag 4 april 2005 7 Nordiska patristi
https://www.ctr.lu.se/fileadmin/user_upload/ctr/pdf/patristik/meddelanden/MCPL19.pdf - 2026-05-23
The Gospel of Matthew as an Argument
This study indicates valuable contributions of narrative criticism and rhetorical criticism. Together with the traditional historical-critical approach, these methods can help us toward an interpretation that lets us better understand the purpose and the function of the gospel-story. One purpose is for it to function as an argument in favour of the standpoint that Jesus is the Son of God, the Mess
Universites And The Agenda 2030
Universities and the 2030 Agenda TEACHING, LEARNING AND ACTING ON THE SUSTAINABLE DEVELOPMENT GOALS ACKNOWLEDGEMENTS Many ideas and contributions have been involved in developing this course. A big thank you to the central unit of Lund University Education Board for supporting this initiative, in particular Sylvia Schwaag Serger. Thanks to all those who contributed video material and reviewed the
