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Background:In Lynch syndrome, inherited mismatch repair (MMR) defects predispose to colorectal cancer and to a wide spectrum of extra-colorectal tumours. Utilising a cohort study design, we aimed to determine the risk of extra-colorectal cancer and to identify yet unrecognised tumour types.Methods:Data from 1624 Lynch syndrome mutation carriers in the Danish hereditary non-polyposis colorectal can

Neuroscience focusing on human development and disease has long been hampered due to ethical reasons, low tissue availability, and low translatability from animal models. To circumvent these obstacles, we have developed two methods for the investigation of human neural cells in culture. Firstly, we present a robust 2-week protocol for the differentiation of human pluripotent stem cells (PSCs) into

Passive integrated transponder (PIT)-tagging is commonly used in behavioural studies of fish, although long-term evaluations of effects from tagging under natural conditions are scarce. We PIT-tagged common bream Abramis brama, European perch Perca fluviatilis, pike Esox lucius and roach Rutilus rutilus, released them in their lakes of origin and recaptured them after 103–3269 days. Overall, tagge

Backgrounds and Purpose- Although new methods for genetic analyses are rapidly evolving, there are currently knowledge gaps in how to detect Mendelian forms of stroke. Methods- We performed whole-exome sequencing in 22 probands, under 56 years at their first ischemic stroke episode, from multi-incident stroke families. With the use of a comprehensive stroke-gene panel, we searched for variants in

In addition to a rise in mean air and water temperatures, more frequent and intense extreme climate events (such as heat waves) have been recorded around the globe during the past decades. These environmental changes are projected to intensify further in the future, and we still know little about how they will affect ecological processes driving harmful cyanobacterial bloom formation. Therefore, w

Objective: To estimate the size of regression to the mean (RTM) for common patient-reported outcomes in trials for knee osteoarthritis (OA). Design: Longitudinal cohort study; we included participants of the Osteoarthritis Initiative who fulfilled typical inclusion criteria for enrolment in a trial. These included: age 40–79 years, symptomatic knee OA, Kellgren-Lawrence grade 2–3, use of pain medi

The development of nanoscale materials is essential across various fields, including catalysis. The intrinsic properties of well-defined nanometre-sized catalysts directly influence their catalytic performance. This thesis investigates the design, fabrication and optimisation of palladium (Pd)-based nanostructures as potential nanocatalysts through a multidisciplinary approach combining state-of-t

Background and aims: Good Selenium (Se) status predicts favorable prognoses for various diseases and a reduced overall mortality. The primary objective of the study was to determine whether Selenium status, i.e. Selenoprotein P (SeP) levels, is associated with risk of 90-day mortality in elderly patients with acute dyspnea at the Emergency Department (ED). Methods and results: Patients presenting

Background: Interferon-γ release assays (IGRAs) for tuberculosis infection (TBI) cannot distinguish different stages of the TBI spectrum (including spontaneously cleared infection). We investigated patterns of Mtb-specific blood mediators in people with and without TBI during tuberculosis preventive therapy (TPT). Methods: Individuals with likelihood of recent Mtb exposure, aged 15–25 years, with

Understanding of carbon nanomaterials oxidation is useful in many different applications, e.g., for soot emission abatement, or in defect engineering aiming to improve material properties. In this work, the oxidative behavior of three substantially different qualities of carbon black, multiwall carbon-nanotubes, and few-layer graphene, was studied using a combination of macroscale quantification (

High disease activity, cognitive dysfunction (CD), fatigue and pain negatively affect the quality of life in patients with systemic lupus erythematosus (SLE). However, the impact on brain perfusion and blood-brain barrier (BBB) permeability remains incompletely understood. Therefore, we utilized 3 T dynamic susceptibility contrast magnetic resonance imaging to investigate these factors in a cohort

We describe a magnetic relation in analogy to the well-known dielectric Lyddane-Sachs-Teller relation [R. H. Lyddane et al., Phys. Rev. 59, 673 (1941)PHRVAO0031-899X10.1103/PhysRev.59.673]. This magnetic relation follows directly from the model equations for nuclear induction due to fast oscillating electromagnetic fields [F. Bloch, Phys. Rev. 70, 460 (1946)PHRVAO0031-899X10.1103/PhysRev.70.460] a

Decoherence of a charge qubit is usually credited to charge noise in the environment. Here we show that charge noise may not be the limiting factor for the qubit coherence. To this end, we study coherence properties of a crystal-phase defined semiconductor nanowire double quantum dot (DQD) charge qubit strongly coupled to a high-impedance resonator using radio-frequency reflectometry. Response of

Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and ethnic disparities. We report a large transancestral association study of SLE using Immunochip genotype data from 27,574 individuals of European (EA), African (AA) and Hispanic Amerindian (HA) ancestry. We identify 58 distinct non-HLA regions in EA, 9 in AA and 16 in HA (50% of these regions have multiple independe

Herein, the grown-into-glass (GIG) CsPbBr3:Ln3+ (Ln = La, Lu) nanocrystals (NCs) are designed and fabricated using an in situ nanocrystallization method. It is shown that a substitution of Pb2+ sites with Ln3+ ions leads to a blueshift of emission position induced by an increase of the bandgap of CsPbBr3. Additionally, the GIG-samples are found to feature excellent photoluminescent (PL) properties

High-order harmonic generation (HHG) in gases leads to short-pulse extreme ultraviolet (XUV) radiation that is useful in a number of applications, such as attosecond science and nanoscale imaging. However, this process depends on many parameters, and there is still no consensus on how to choose the target geometry to optimize the source efficiency. We review the physics of HHG with emphasis on the

Ultra-thin high-Al content barrier layers can enable improved gate control and high-frequency operation of AlGaN/GaN high electron mobility transistors (HEMTs) but the precise composition control is very challenging. In this work, we investigate the compositional profiles of AlxGa1−xN/GaN HEMT structures with targeted Al content in the barrier layer, x = 0.50, 0.70, and 1, and thickness in the sub

There is a growing interest in reconstructing the density matrix of photoelectron wavepackets, in particular in complex systems where decoherence can be introduced either by a partial measurement of the system or through coupling with a stochastic environment. To this end, several methods to reconstruct the density matrix, quantum state tomography protocols, have been developed and tested on photo

Developing a reliable procedure for the growth of III-V nanowires (NW) on silicon (Si) substrates remains a significant challenge, as current methods rely on trial-and-error approaches with varying interpretations of critical process steps such as sample preparation, Au-Si alloy formation in the growth reactor, and NW alignment. Addressing these challenges is essential for enabling high-performanc