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BACKGROUND Clonal hematopoiesis of indeterminate potential (CHIP) and clonal cytopenia of undetermined significance (CCUS) are defined by somatic mutations in genes associated with myeloid neoplasms (MN) at a variant allele fraction (VAF) of 0.02 or greater in the absence and presence of cytopenia, respectively. CHIP/CCUS is highly prevalent in adults, and defining predictors of MN risk would aid
Background: Breast cancer polygenic risk scores (PRS) and traditional risk models (e.g., the Gail model [Gail]) are known to contribute largely independent information, but it is unclear how the overlap varies by ancestry, age, disease type (invasive breast cancer, DCIS), and risk threshold. Methods: In a retrospective case–control study, we evaluated risk prediction performance in 180,398 women (
Hedgehog (Hh) signaling is essential for embryonic development and tissue homeostasis in organisms. However, Caenorhabditis elegans lacks canonical Hh signaling due to the absence of key components, such as smoothened (SMO) and obvious Hh ligands. Despite this, C. elegans retains Patched homologs, ptc-1 and ptc-3, which have specialized independent functions. Although ptc-1 is predominantly ex
Taurine, an amino sulfonic acid abundant in seafood and meat, has been proposed to have a potential role in the prevention of metabolic dysfunction-associated steatotic liver disease (MASLD) due to its antioxidant and anti-inflammatory properties. However, the association between dietary taurine intake and MASLD remains unclear in human populations. Also, data on dietary taurine intake among adult
Background: Standardized definitions of autoimmune disease (AD) are lacking. Therefore, we aim to propose a definition of AD for register-based research and estimate the burden of AD in Sweden as registered in the National Patient Register (NPR) from 1980 to 2023. Methods: Leveraging the NPR, we defined AD as having at least two relevant International Classification of Diseases (ICD) codes represe
An abdominal aortic aneurysm (AAA) is defined as aortic diameter ≥30 mm measured by ultrasound. AAA prevalence increases with age and is higher in men, but has decreased during the last decades, related to lower smoking rates. Tobacco smoking, concomitant atherosclerosis, arterial hypertension, and family history are the most common risk factors. AAA has atherosclerotic, inflammatory, apoptotic, a
Antipsychotic drugs (APD) are commonly prescribed to people living with dementia (PwD) to manage behavioral and psychological symptoms of dementia (BPSD), despite well-documented safety concerns. International guidelines recommend non-pharmacological interventions as first-line treatment, yet APDs remain widely used. This systematic review and meta-analysis synthesize current evidence on the conse
Tryptophan is an essential amino acid for the human body and is crucial for protein synthesis. It is primarily metabolized through the kynurenine, 5-hydroxytryptamine, and indole pathways. The various bioactive compounds produced through tryptophan metabolism can regulate a range of physiological functions, including digestive, metabolic, immune responses, and neurological functions. New evidence
Förslag på studieplanering för blivande präster - Start VT2017 Huvudspecialisering inkl kandidatuppsats i Religionshistoria Svenska kyrkans akademiska studiekrav: och religionsbeteendevetenskap 255 hp inkl teol kand och magisterexamen 2011 års studieordning, CTR 180 hp Teol kand 2013 års utbildningsordning för blivande präster, Svenska kyrkan Religionsvetenskap och teologi: Grundkurs 30 Specialise
https://www.ctr.lu.se/fileadmin/_migrated/content_uploads/Studieplanering_blivande_praester__start_VT17__RHI_RBV.pdf - 2026-05-18
Martin Widerberg berättar om livet som student på Beteendevetenskapliga programmet.
Saco-rådet Umeå kommun KALLELSE 2015-02-27 Saco-rådsrepresentanter/ Saco-medlemmar KALLELSE TILL SACO-RÅDETS ÅRSMÖTE Tid Tisdag 2015-03- 24 kl. 17.00 Plats Ägirs gästabud, Folkets hus (1 tr ner) Program Årsmöte. I samband med årsmötesförhandlingarna bjuder Saco-rådet på krämig fisksoppa med grönsaker, färskost och bröd samt kaffe. Önskas specialkost meddelas det i samband med anmälan. Anmälan Sena
The exceptional polymorphism observed within genes of the major histocompatibility complex (MHC), a core component of the vertebrate immune system, has long fascinated biologists. The highly polymorphic classical MHC class-I (MHC-I) genes are maintained by pathogen-mediated balancing selection (PMBS), as shown by many sites subject to positive selection, while the more monomorphic non-classical MH
Climate change has been associated with both latitudinal and elevational shifts in species’ ranges. The extent, however, to which climate change has driven recent range shifts alongside other putative drivers remains uncertain. Here, we use the changing distributions of 378 European breeding bird species over 30 years to explore the putative drivers of recent range dynamics, considering the effect
Next milestone on Lund University’s road to Science Village: landlord wanted Hoppa till huvudinnehåll Vi använder cookies och andra spårningsteknologier för att förbättra användarupplevelsen på vår webbplats, för att visa dig personligt innehåll och riktade annonser och för att analysera vår webbplatstrafik. Läs mer om cookies. Absolut nödvändiga cookies Dessa cookies är nödvändiga för att webbpla
https://www.lth.se/article/next-milestone-on-lund-universitys-road-to-science-village-landlord-wanted/ - 2026-05-18
Type 2 diabetes (T2D) and cardiovascular disease (CVD) are highly prevalent complex diseases that result from lifestyle and genetic factors. Gene-lifestyle interactions are also believed to contribute to the etiology of these diseases. The aim of this thesis was to investigate gene-lifestyle interactions using the strongest T2D and CVD susceptibility genetic loci and to understand the causal natur
Parkinson’s disease (PD) is currently the second most common neurodegenerative disorder (after Alzheimer’s disease). PD is diagnosed on its motor symptoms, which include akinesia, bradykinesia, rigidity, postural imbalance and resting tremor. It is well established that the motor symptoms develop due to lack of dopamine in the striatum. This is caused by progressive degeneration of dopaminergic ne
I föreliggande psykologexamensuppsats kombinerades kvalitativa och kvantitativa metoder i syfte att explorativt undersöka innehållet i pedagogers samtalsgrupper samt för att utforska samtalsledarens roll. Studien utformades i samråd med utbildningsförvaltningen i den studerade kommunen. Åtta samtalsgrupper deltog i en observationsundersökning. Ett strukturerat observationsschema, IPA, användes förIn the presented Master’s Thesis qualitative and quantitative methods were combined in order to, with an explorative approach, examine the content of the Teacher Learning Communities (TLC) and to examine the role of the facilitator. The study was developed in agreement with the Department of Education in the participating municipality. Eight TLCs were observed. A structured observation chart, IPA,
Urbanization is gaining force globally, which challenges biodiversity, and it has recently also emerged as an agent of evolutionary change. Seasonal phenology and life cycle regulation are essential processes that urbanization is likely to alter through both the urban heat island effect (UHI) and artificial light at night (ALAN). However, how UHI and ALAN affect the evolution of seasonal adaptatio
