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Large-scale gene sequencing studies for complex traits have the potential to identify causal genes with therapeutic implications. We performed gene-based association testing of blood lipid levels with rare (minor allele frequency < 1%) predicted damaging coding variation by using sequence data from >170,000 individuals from multiple ancestries: 97,493 European, 30,025 South Asian, 16,507 African,
The surface chemistry of the initial growth during the first or first few precursor cycles in atomic layer deposition is decisive for how the growth proceeds later on and thus for the quality of the thin films grown. Yet, although general schemes of the surface chemistry of atomic layer deposition have been developed for many processes and precursors, in many cases, knowledge of this surface chemi
Sea salt aerosol particles are highly abundant in the atmosphere and play important roles in the global radiative balance. After influence from continental air, they are typically composed of Na+, Cl-, NH4+, and SO42- and organics. Analogous particle systems are often studied in laboratory settings by atomizing and drying particles from a solution. Here, we present evidence that such laboratory st
One of the major arguments made in the current boom in Haitian revolutionary studies connects today’s conditions of possibility for modern democracy and human rights to the abolition of slavery during the Haitian Revolution (1791–1804). During the last decade, however, this connection between the Haitian Revolutionary period and our own age has been questioned by an increasing number of scholars:
Mouse hematopoietic stem cells (HSCs) have been extensively defined both molecularly and functionally at steady state, while regenerative stress induces immunophenotypical changes that limit high purity isolation and analysis. It is therefore important to identify markers that specifically label activated HSCs to gain further knowledge about their molecular and functional properties. Here, we asse
Background: Atherosclerotic plaque ruptures, triggered by blood flow–associated biomechanical forces, cause most myocardial infarctions and strokes. Objectives: This study aims to investigate the exact location and underlying mechanisms of atherosclerotic plaque ruptures, identifying therapeutic targets against cardiovascular events. Methods: Histology, electron microscopy, bulk and spatial RNA se
OBJECTIVE: HER2/ErbB2 is a member of the epidermal growth factor receptor family. It is widely used as a tumor marker, but it also has recently been associated with insulin resistance. Both ErbB2 and diabetes have been associated with cancer; however, the relationship between ErbB2 and diabetes has not been well explored. The aim of this population-based cohort study was to assess the association
Global warming is driving environmental change in the Arctic. However, our current understanding of this change varies strongly among different environmental disciplines and is limited by the number and distribution of field sampling locations. Here, we use a quantitative framework based on multivariate statistical modeling to present the current state of sampling across environmental disciplines
A vertical temperature stratification normally exists in rooms during the heat-ing season in cold climates. An expression of the gradient in apartments heated by hydronic radiator heating systems with exhaust ventilation has ear-lier been developed assuming a dependency of the outdoor temperature. The expression was used by a public real estate owner when re-calculating meas-ured indoor temperaturA vertical temperature stratification normally exists in rooms during the heat-ing season in cold climates. An expression of the gradient in apartments heated by hydronic radiator heating systems with exhaust ventilation has ear-lier been developed assuming a dependency of the outdoor temperature. The expression was used by a public real estate owner when re-calculating meas-ured indoor temperatur
With global politics increasingly fractured, states are rushing to secure critical and strategic mineral supply chains. Each state conceptualizes mineral security differently, driven by a mix of imperatives that range from national development and industrial policy to technological and military dominance. Great power competition pervades all of these issue areas, and that competition may also pose
Objectives: There are several breast cancer (BC) risk factors—many related to body composition, hormonal status, and fertility patterns. However, it is not known if risk factors in healthy women are associated with specific mammographic features at the time of BC diagnosis. Our aim was to assess the potential association between pre-diagnostic body composition and mammographic features in the diag
Objectives: To evaluate the feasibility of AI-assisted reading of prostate magnetic resonance imaging (MRI) in Organized Prostate cancer Testing (OPT). Methods: Retrospective cohort study including 57 men with elevated prostate-specific antigen (PSA) levels ≥3 µg/L that performed bi-parametric MRI in OPT. The results of a CE-marked deep learning (DL) algorithm for prostate MRI lesion detection wer
This paper discusses a presumed medieval tower in Blekinge. The tower is situated close to a harbour in an inlet of the Baltic just east of modern day Ronnebyhamn. Archaeological investigations in 2021 and 2023 have however firmly dated the tower to the 17th century, making it the first Scandinavian example of a tower-house from the Early Modern era. The tower originally had at least three floor-l
Background. The estimation of glomerular filtration rate (GFR) is one tool to detect renal disease. The most used biomarker remains serum creatinine and the European Kidney Function Consortium (EKFCcrea ) equation is the most validated in Europe. More recently, cystatin C has been proposed as a biomarker. We studied the performances of the EKFC equations in a large cohort of subjects according to
The leadership literature has been faulted for framing leaders (and followers) as rational and disembodied information processers. This chapter presents a review of studies that go against this tendency by focusing on how materiality, embodiment, and aesthetics are involved in leadership communication. A number of different perspectives are highlighted in relation to the three focal themes, as wel
Knowledge of human fetal blood development and how it differs from adult blood is highly relevant to our understanding of congenital blood and immune disorders and childhood leukemia, of which the latter can originate in utero. Blood formation occurs in waves that overlap in time and space, adding to heterogeneity, which necessitates single-cell approaches. Here, a combined single-cell immunopheno
In this study we ask how a range of environmental sustainability adjustments that consumers find it easy to adopt affect the carbon footprint of their food consumption. The study is based on information about real purchases offood products and responses to a questionnaire about the various sustainability adjustments that the study participants apply and their concern about climate change. Based onIn this study we ask how a range of environmental sustainability adjustments that consumers find it easy to adopt affect the carbon footprint of their food consumption. The study is based on information about real purchases of food products and responses to a questionnaire about the various sustainability adjustments that the study participants apply and their concern about climate change. Based o
α-Synuclein is an intrinsically disordered presynaptic protein associated with Parkinson's disease. The physiological role of α-Synuclein is not fully understood, but the protein is known to interact with lipid membranes. We here study how membrane charge affects the adsorption of α-Synuclein to (i) supported lipid bilayers and (ii) small unilamellar vesicles with varying amounts of anionic lipids
Mucosa-associated lymphoid tissue protein 1 (MALT1) plays a key role in adaptive immune responses by modulating specific intracellular signalling pathways that control the development and proliferation of both T and B cells. Dysfunction of these pathways is coupled to the progress of highly aggressive lymphoma as well as to potential development of an array of different immune disorders. In contraMucosa-associated lymphoid tissue protein 1 (MALT1) plays a key role in adaptive immune responses by modulating specific intracellular signalling pathways that control the development and proliferation of both T and B cells. Dysfunction of these pathways is coupled to the progress of highly aggressive lymphoma as well as to potential development of an array of different immune disorders. In contra
