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Genetic variation at the 19q13.3 KLK locus is linked with prostate cancer susceptibility in men. The non-synonymous KLK3 single nucleotide polymorphism (SNP), rs17632542 (c.536 T > C; Ile163Thr-substitution in PSA) is associated with reduced prostate cancer risk, however, the functional relevance is unknown. Here, we identify that the SNP variant-induced change in PSA biochemical activity mediates
OBJECTIVES: To examine cardiovascular autonomic function in middle-aged people with long-term cervical and upper thoracic spinal cord injury (SCI) compared with the general population, and explore if the neurological level of injury (NLI) is related to cardiovascular autonomic function.DESIGN: Population-based cross-sectional study with matched controls.SETTING: Outpatient SCI unit in Southern Swe
Cardiovascular disease (CVD) is the leading cause of mortality and morbidity worldwide. While sociodemographic, dietary and lifestyle factors have been well documented in relation to CVD, environmental factors have been less studied. However, considering the ongoing biodiversity, climate, and health crises, it is imperative to better understand the interplay between the environment and health. Thi
α1-microglobulin (A1M) is a small protein present in vertebrates including humans. It has several physiologically relevant properties, including binding of heme and radicals as well as enzymatic reduction, that are used in the protection of cells and tissue. Research has revealed that A1M can ameliorate heme and ROS-induced injuries in cell cultures, organs, explants and animal models. Recently, i
As cardio metabolic disease manifestations tend to cluster in families there is a need to better understand the underlying mechanisms in order to further develop preventive strategies. In fact, genetic markers used in genetic risk scores, important as they are, will not be able alone to explain these family clusters. Therefore, the search goes on for the so called missing heritability to better ex
The association between blood pressure (BP) and bladder cancer (BC) risk remains unclear with confounding by smoking being of particular concern. We investigated the association between BP and BC risk among men using conventional survival-analysis, and by Mendelian Randomization (MR) analysis in an attempt to disconnect the association from smoking. We additionally investigated the interaction bet
Drainage networks delineated from Digital Elevation Models (DEMs), are the basis for the modelling of geomorphological and hydrological processes, biogeochemical cycling, and water resources management. Besides providing effective models of water flows, automatically extracted drainage networks based on topography can diverge from reality to varying degrees. The variability of such disagreement wi
Apprenticeship training in Sweden and many other European countries goes back to the middle ages. Yet, this special model of vocational education still attracts significant interest due to the challenges young people face in preparing to enter the current labour market. This is obvious both in Sweden and in other comparable countries. The apprenticeship model is primarily promoted as achieving twoApprenticeship training in Sweden and many other European countries goes back to the middle ages. Yet, this special model of vocational education still attracts significant interest due to the challenges young people face in preparing to enter the current labour market. This is obvious both in Sweden and in other comparable countries. The apprenticeship model is primarily promoted as achieving two
Osteoarthritis is one of the most common musculoskeletal diseases and increases the risk of severe cardiovascular disease, like heart attack and stroke. In some individuals, osteoarthritis and cardiovascular disease will co-occur. This co-occurrence might be due to shared risk factors, for example high age, lifestyle factors and/or a shared genetic liability for the two diseases. Here, we show tha
BACKGROUND: Complement activation may promote atherosclerosis. Yet, data on the to which extent complement, and more specifically the alternative complement pathway, is activated in patients with carotid atherosclerosis and related to adverse outcome in these patients, are scarce.METHODS AND RESULTS: We measured, by ELISA, plasma levels of factor D, properdin, C3bBbP (C3 convertase), and factor H
Controlling the streaming flow in acoustically actuated microchannels enables the targeted motion of suspended micro-objects. This can offer novel approaches for rare cell studies or cell sorting in medicine or basic biology. In this work, we utilize the temperature dependence of the acoustic body force, which originates from the interaction of an acoustic field with gradients in compressibility o
sarah thesis final.doc INCORRIGIBLY PLURAL On what grounds can we acknowledge a diversity of perspectives in sustainability science? A thesis submitted to LUMES, the Lund University International Master’s Programme in Environmental Studies and Sustainability Science 25 May 2009 Submitted by Supervised by Sarah Kollnig Turaj Faran sarah.kollnig@gmx.at LUCSUS (Lund University Centre for Sustainabili
https://www.lumes.lu.se/sites/lumes.lu.se/files/kollnig_sarah_0.pdf - 2026-07-15
From Bowling Alone to Dining Together: a Sustainability Analysis of Cohousing in the United States Stacey Frisk Lund University Master of Environmental Studies and Sustainability Science Graduate Thesis May 23, 2007 Supervised by: Barry Ness P.O. Box 170, SE-221 00 LUND, Sweden +46 (0) 46 - 222 05 12 barry.ness@lucsus.lu.se - 2 - For the Children The rising hills, the slopes, of statistics lie bef
https://www.lumes.lu.se/sites/lumes.lu.se/files/stacey_frisk.pdf - 2026-07-15
SingleRespondentReport_Main Strategic Research Environment questionnaire 2013Vinnova Sida 1 av 30 Based on our initial application (2009) the three main priorities set in 2013 were the following for the strategic research area Epidemiology for Health (SRA EpiHealth): 1. To further strengthen an infrastructure for EpiHealth linking Lund University (LU) and Uppsala University (UU). 2. To promote exc
https://www.epihealth.lu.se/sites/epihealth.lu.se/files/verksamhetsuppfoljning_2013.pdf - 2026-07-15
The incidence of cutaneous melanoma (CM) has risen sharply over the past 30 years, coinciding with the rapidly growing tattoo trend. In Sweden, 20% of the population is tattooed. Repeated reports of the presence of carcinogenic chemicals, such as polyaromatic hydrocarbons, aromatic amines and heavy metals in tattoo ink justifies the investigation of CM risk in relation to tattooing. We aimed to in
Nano Lund Annual Report 2023 NanoLund ANNUAL REPORT | 2024 2024 in brief THE YEAR IN NUMBERS NANOLUND INCLUDES PUBLICATIONS 22 recipients of European Research Council (ERC) awards 6 Wallenberg Scholars or Fellows 3 Distinguished professors, Swedish Research Council 19 ongoing EU-projects 8 ongoing Wallenberg projects and Research environment grants from the Swedish Research Council 454 publication
https://www.nano.lu.se/sites/nano.lu.se/files/2025-06/lowres_380332_A%CC%8Arsrapport_NanoLund_2024_enkels.pdf - 2026-07-15
Determining the land cover (LC) data requirements used as input to noise simulations is essential for planning sustainable urban densifications. This study examines how different LC datasets influence simulated environmental noise levels of road traffic using Nord2000 in an urban area of 1 km2 in southern Sweden. Four LC datasets were used. The first dataset was based on satellite data (spatial re
Conventional dendritic cells (cDCs) are potent antigen-presenting cells (APCs) that integrate signals from their environment allowing them to direct situation-adapted immunity. Thereby they harbor great potential for being targeted in vaccination, autoimmunity, and cancer. Here, we use fate mapping, functional analyses, and comparative cross-species transcriptomics to show that RORγt+ DCs are a co
