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A cell’s ability to sense and respond to the mechanical properties of the extracellular matrix (ECM) is essential for maintaining tissue homeostasis, and its disruption contributes to diseases such as fibrosis, cardiovascular disorders, and cancer. Effective mechanical coupling between the plasma membrane, the underlying filamentous actin (F-actin) cytoskeleton, and integrin-based adhesion complex
The International Agency for Research on Cancer has recently classified occupational exposure as a firefighter as carcinogenic (group 1A). Even though the occupation of firefighter is associated with high exposure to pollutants, it is challenging to carry out exposure studies to assess health risks due to the extreme conditions associated with firefighting. Routine monitoring of occupational expos
BACKGROUND AND AIMS: Atherosclerotic plaques are the leading cause of cardiovascular events. Single-cell approaches have identified diverse human plaque cell phenotypes but their spatial distribution and interactions remain unclear. Here, intercellular communication patterns in human plaque microenvironments were mapped to reveal novel targets to prevent atherosclerotic events.METHODS: Spatial tra
We present a microchannel-based adaptation of mass density-gradient centrifugation for the mass density measurement of cells or microparticles. The workflow consists of three basic steps: Microchannel filling, centrifugation, and microscopy. Microchannel filling and subsequent centrifugation of two liquids with different densities allows the instantaneous, precise, and repeatable generation of a o
Background: There is limited data on the organisation of paediatric echocardiography laboratories in Europe. Methods: A structured and approved questionnaire was circulated across all 95 Association for European Paediatric and Congenital Cardiology affiliated centres. The aims were to evaluate: (1) facilities in paediatric echocardiography laboratories across Europe, (2) accredited laboratories, (
BACKGROUND: Systemic lupus erythematosus (SLE) patients, with or without neuropsychiatric SLE (NPSLE), exhibit greater neuronal impairment compared to healthy individuals in terms of neuronal damage, magnet resonance imaging (MRI) changes and cognitive dysfunction. Interferon (IFN)-α is a key immunopathogenic driver of SLE, being persistently overexpressed in the majority of patients. This longitu
Low vaccination coverage against SARS-CoV-2 (COVID-19) is a public health concern. The aim of this study was to identify barriers and motivators associated with COVID-19 vaccination and develop a vaccine acceptance scoring system. From the overall population residing in Skåne county Sweden in 2022 (n = 1 384 531), 3600 randomly selected individuals (aged ≥18 years) received a survey. Questions wer
Background Von Willebrand factor (VWF) and coagulation factor VIII (FVIII) plasma levels are associated with increased risk for venous thromboembolism (VTE). Objectives This study aimed to determine the thrombotic risk of rare and common variants of 27 genes linked to VWF or FVIII plasma levels in genome-wide association studies. Methods Exon sequences of 27 genes linked to plasma levels of VWF or
Conventional dendritic cells (cDCs) are potent antigen-presenting cells (APCs) that integrate signals from their environment allowing them to direct situation-adapted immunity. Thereby they harbor great potential for being targeted in vaccination, autoimmunity, and cancer. Here, we use fate mapping, functional analyses, and comparative cross-species transcriptomics to show that RORγt+ DCs are a co
Objectives: To assess amide proton transfer weighted (APTw) MR imaging capabilities in differentiating high-grade glial tumors across alpha-thalassemia/mental retardation X-linked (ATRX) expression, tumor-suppressor protein p53 expression (p53), O6-methylguanine-DNA methyltransferase promoter (MGMTp) methylation, isocitrate dehydrogenase (IDH) status, and proliferation marker Ki-67 (Ki-67 index)
Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer lacking effective drugs and therefore new treatment targets are needed. In this study, we define the role of homeobox protein B6 (HOXB6) and HOXB8 in controlling pancreatic cancer tumorigenesis and immune response. Transcriptomic analysis comparing human embryonic and PDAC tissue identified a large overlap of expression profiles suggesting
Arbetsordning och delegationer COVER PAGE: GUIDANCE DOCUMENTS Rules of Procedure for the Faculty of Science and the Faculty Board’s delegations to the Dean Type of policy document: Guidelines Definition of the type of policy document: Sets out how someone must or should act within the area covered by the guidelines. A ‘must’ rule must be followed, whilst a ‘should’ rule is more in the nature of a
The Purpose of this study was to examine how family law secretaries describe children's participation in custody, housing and contact investigations before and after the implementation of the Convention on the Rights of the Child. The results are analyzed by two theories, the room for maneuver for the bureaucrat at street level by Michael Lipsky and the participation model by Roger Hart. The e
This qualitative case-study highlights the importance of the phenomenon of migration, under the aspect of civic activism of migrants, and its impact on Italian agricultural sustainable development. Migrants are too often seen as a burden rather than active agents of development. The present research investigates how political activism of migrants develops and eventually affects the sustainable dev
Steg 2: UTÅT – Vad finns? | Sveriges akademikers centralorganisation Hoppa till huvudinnehåll till startsida Öppna sökruta Öppna Huvudmeny Sök på saco.se Om Saco Kontakt Anställda hos Saco Saco studentråd Sacos styrelse Sacos revisorer Sacos organisation Sacos styrelse Kontaktuppgifter Sacos styrelse Verksamhetsberättelse och årsredovisning Federationen och förbunden Medlemsstatistik Förbunden Sac
https://www.saco.se/studier/studieval/guiden-inat-utat-framat/utat---vad-finns/ - 2026-06-29
Jämför löner | Sveriges akademikers centralorganisation Hoppa till huvudinnehåll till startsida Öppna sökruta Öppna Huvudmeny Sök på saco.se Om Saco Kontakt Anställda hos Saco Saco studentråd Sacos styrelse Sacos revisorer Sacos organisation Sacos styrelse Kontaktuppgifter Sacos styrelse Verksamhetsberättelse och årsredovisning Federationen och förbunden Medlemsstatistik Förbunden Saco Hälso- och
https://www.saco.se/studier/studieval/jamfor-loner/ - 2026-06-29
