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Partially Premixed Combustion (PPC) has shown its potential by combining high combustion controllability with emission characteristics that are close to those of an HCCI engine. In order to get PPC the ignition delay needs to be long enough for the fuel and air to mix prior to combustion. This can be achieved by injecting the fuel sufficiently early while running with high EGR.In order to find out

The search for new cancer biomarkers is essential for fundamental research, diagnostics, as well as for patient treatment and monitoring. Whereas most cancer biomarkers are biomolecules, an increasing number of studies show that mechanical cues are promising biomarker candidates. Although cell deformability has been shown to be a possible cancer biomarker, cellular forces as cancer biomarkers have

Melphalan at a dose of 200 mg/m2 is standard conditioning prior to autologous hematopoietic stem cell transplantation for multiple mulholger, but a dose of 140 mg/m2 is often used in clinical practice in patients perceived to be at risk of excess toxicity. To determine whether melphalan 200 mg/m2 and melphalan 140 mg/m2 are equally effective and tolerable in clinically relevant patient subgroups w

There are a few studies that report cognitive impairment as a complication of treatment with beta- blockers. We aimed to evaluate the longitudinal association between use of beta-blockers, as a class, and incident risk of all-cause dementia, vascular dementia, Alzheimer's and mixed dementia in the prospective population-based Malmö Preventive Project. We included 18,063 individuals (mean age 68.2,

Clonal heterogeneity and evolution has major implications for disease progression and relapse in acute myeloid leukemia (AML). To model clonal dynamics in vivo, we serially transplanted 23 AML cases to immunodeficient mice and followed clonal composition for up to 15 months by whole-exome sequencing of 84 xenografts across two generations. We demonstrate vast changes in clonality that both progres

Mutations in the FMS-like tyrosine kinase 3 (FLT3) gene in 13q12.2 are among the most common driver events in acute leukemia, leading to increased cell proliferation and survival through activation of the PI3K/AKT, RAS/MAPK and STAT5 signaling pathways. In this study, we examine the pathogenetic impact of somatic hemizygous 13q12.2 microdeletions in B-cell precursor acute lymphoblastic leukemia (B

Objective To investigate the association of infections with the subsequent development of giant cell arteritis (GCA) in a large population-based cohort from a defined geographic area in Sweden.Methods Patients diagnosed with biopsy-confirmed GCA between 2000 and 2016 were identified through the database of the Department of Pathology in Skåne, the southernmost region of Sweden. For each GCA case,

The electrocardiographic PR interval reflects atrioventricular conduction, and is associated with conduction abnormalities, pacemaker implantation, atrial fibrillation (AF), and cardiovascular mortality. Here we report a multi-ancestry (N = 293,051) genome-wide association meta-analysis for the PR interval, discovering 202 loci of which 141 have not previously been reported. Variants at identified

Laser Shock Peening (LSP) and conventional Shot Peening (SP) are processes that aim to improve the surface properties of a workpiece by inducing compressive residual stresses. The peening processes also cause martensitic phase transformation in austenitic steels. Interestingly, experimental studies report significant differences in martensite content depending on the used peening process. This stuLaser Shock Peening (LSP) and conventional Shot Peening (SP) are processes that aim to improve the surface properties of a workpiece by inducing compressive residual stresses. The peening processes also cause martensitic phase transformation in austenitic steels. Interestingly, experimental studies report significant differences in martensite content depending on the used peening process. This stu

Culture conditions in which hematopoietic stem cells (HSCs) can be expanded for clinical benefit are highly sought after. Here, we report that inhibition of the epigenetic regulator Lysine-specific histone demethylase 1A (LSD1) induces a rapid expansion of human cord blood derived CD34+ cells and promotes in vitro propagation of long-term repopulating HSCs by preventing differentiation. The phenot

For well over a century, migration researchers have recognized the lack of adequate distance measures to be a key obstacle for advancing understanding of internal migration. The problem arises from the convention of spatially defining migration as the crossing of administrative borders. Because administrative regions vary in size, shape, and settlement patterns, it is difficult to tell how far mov

The Transfermium Working Group (TWG) was set up in 1986 under the joint auspices of the International Union of Pure and Applied Chemistry (IUPAC) and the International Union of Pure and Applied Physics (IUPAP). Its conclusions, duly endorsed by IUPAC and IUPAP, were published in the following three reports:1. Criteria that must be satisfied for the discovery of a new chemical element to be recogni

Even though Sweden stands out in many ways, with for example a well-developed welfare system, there are some indications that Swedish egalitarianism does not include tolerance for people with low income. The present research concerns the content of the Swedish stereotype of poor people, and examines whether the poor are associated with just as negative traits as they are in other countries. Three

This paper situates political assassinations by Western states in the global south in a wider discussion concerning decolonization and the progressivist narrative of international law. The paper looks at three generations of such assassinations, focusing on the international legal environments in which they took place and setting the parameters for both legitimation and opposition: the mid-twentie

Transition-metal complexes are used as photosensitizers1, in light-emitting diodes, for biosensing and in photocatalysis2. A key feature in these applications is excitation from the ground state to a charge-transfer state3,4; the long charge-transfer-state lifetimes typical for complexes of ruthenium5 and other precious metals are often essential to ensure high performance. There is much interest

Background: Diabetes mellitus is linked to premature mortality of virtually all causes. Furin is a proprotein convertase broadly involved in the maintenance of cellular homeostasis; however, little is known about its role in the development of diabetes mellitus and risk of premature mortality. Objectives: To test if fasting plasma concentration of furin is associated with the development of diabet

A search for exotic decays of the Higgs boson into a pair of spin-zero particles, H → aa, where the a-boson decay sin to b-quarks promptly or with a mean proper lifetime cτa up to 6 mm and has a mass in the range of 20–60 GeV, is presented. The search is performed in events where the Higgs boson is produced in association with a W or Z boson, giving rise to a signature of one or two charged lepton

The newly developed website ’Den botaniska skattkammaren’ [The botanic treasury; www.botskatt.se] is presented. It is intended to be gradually filled with miscellaneous information about vascular plant taxa found in, or expected to be found in Swedish nature (i.e. including all kinds of ephemerals and garden escapes). The material included will partly be newly produced, partly reproduced with permThe newly developed website ’Den botaniska skattkammaren’ [The botanic treasury; www.botskatt.se] is presented. It is intended to be gradually filled with miscellaneous information about vascular plant taxa found in, or expected to be found in Swedish nature (i.e. including all kinds of ephemerals and garden escapes). The material included will partly be newly produced, partly reproduced with perm