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BackgroundThe lack of effective screening methods for the detection of ovarian cancer leads to late diagnosis and poor outcomes. High-grade serous ovarian carcinoma (HGSC) is strongly dominated by copy number alterations (CNAs), resulting from underlying mutational processes. Several studies have reported the detection of ovarian carcinoma-derived somatic mutations in cervical samples, uterine lav
Over recent years many urban areas have experienced severe floods caused by extreme precipitation events. To avoid the devastating socioeconomic and environmental consequences of such floods, countries have issued laws or recommendations on flood risk assessment in urban planning. However, these laws or recommendations seldom include detailed requirements on input data quality or explicit instruct
In 2020, a case report described autologous transplantation of iPSC-derived dopamine (DA) neurons in a Parkinson's disease (PD) patient.1 The team now follows up with the pre-clinical safety and efficacy data of autologous iPSC-derived DA neurons, forming the basis for regulatory approval of a phase 1 clinical trial involving 8 patients.2
In this study, we demonstrate a successful application of laser absorption spectroscopy in an in-situ optical diagnostic system to map the radial distribution of the number density of vapor-phase aluminum (Al) atoms around a burning micron-sized Al droplet. This technique overcomes the challenges associated with the short optical path (at micron scale) and offers high sensitivity to Al atom concen
The efficacy of cancer immunotherapy relies on the recruitment and activation of cytotoxic T cell responses against solid tumors by type 1 conventional dendritic cells (cDC1s). However, the generation of cDC1s for cancer immunotherapy faces significant limitations, including poor cell yield, functional heterogeneity, and susceptibility to immunosuppression in the tumor microenvironment (TME). We r
Aims: To explore the association between soluble neuropilin-1 (sNRP-1) and depression in patients with newly diagnosed type 2 diabetes (T2D). Materials and Methods: Multicentre, cross-sectional study including adults with serologically confirmed newly diagnosed T2D. Included variables: sex, sNPR-1 (low sNRP-1 was defined as <226 ng/mL), psychometrically assessed depression and anxiety, antidepress
The human influence on Earth's ecosystems is omnipresent. Artificial light at night (ALAN), anthropogenic noise, and air pollution are inherent features of human activities and infrastructure and pose novel environmental challenges to urban-dwelling wildlife. So far, most of the studies investigating the impacts of exposure to urban pollutants on animals have either investigated the effects of urb
The co-occurrence of α-synuclein (αSyn) and Tau in synucleinopathies and tauopathies suggests a complex interplay between these proteins. Their cross-seeding enhances fibrillization, leading to the formation of diverse amyloid-specific structures enriched with β-sheets, which may influence their biological functions. However, existing tools cannot differentiate structural polymorphs directly in ce
Dilated cardiomyopathy (DCM) is a leading cause of heart failure and cardiac transplantation. We report a genome-wide association study and multi-trait analysis of DCM (14,256 cases) and three left ventricular traits (36,203 UK Biobank participants). We identified 80 genomic risk loci and prioritized 62 putative effector genes, including several with rare variant DCM associations (MAP3K7, NEDD4L a
Newts have large genomes harbouring many repeat elements. How these elements shape the genome and relate to newts’ unique regeneration ability remains unknown. We present here the chromosome-scale assembly of the 20.3Gb genome of the Iberian ribbed newt, Pleurodeles waltl, with a hitherto unprecedented contiguity and completeness among giant genomes. We provide evidence that intronic repeat elemen
This paper presents the first online, in-situ experimental evidence of the puffing behavior of aluminium (Al) atoms during the ignition of a micron-sized Al wire. As the protective alumina (Al2O3) layer ruptures, spatially resolved laser absorption measurements reveal the outward puffing of Al atoms from the molten Al wire core. These Al atoms then react with the surrounding oxidizers, leading to
To evaluate a simplified version of the Clinical Frailty Scale (SCFS) among older adults presenting to the emergency department (ED) with acute dyspnea. In this retrospective single-center cohort study, we included patients from the Acute Dyspnea Study (ADYS) cohort. Severity of illness was assessed using the Medical Emergency Triage and Treatment System (METTS). SCFS was operationalized using exi
Aim: To summarise key epidemiological and therapeutic research on osteoarthritis (OA) published between April 2024 and March 2025. Methods: A narrative review was conducted using the MEDLINE database, focusing on English-language studies involving human participants published between April 1, 2024 and March 31, 2025. Eligible studies included observational longitudinal studies, systematic reviews,
Chaperone proteins are essential for maintaining proteostasis. Their main role is to assist with the folding of other proteins and to prevent the aggregation of misfolded proteins. The molecular chaperone DNAJB6b efficiently suppresses amyloid formation of several peptides. This activity may rely on the same physicochemical properties as those driving chaperone self-assembly into large micellar-li
The unprecedented x-ray flux density provided by modern x-ray sources offers new spatiotemporal possibilities for x-ray imaging of fast dynamic processes. Approaches to exploit such possibilities often result in either (i) a limited number of projections or spatial information due to limited scanning speed, as in time-resolved tomography, or (ii) a limited number of time points, as in stroboscopic
Purpose: The Paleolithic Diet Fraction (PDF) estimates the proportion of absolute dietary intake derived from food groups included in the Paleolithic diet. In the Malmö Diet and Cancer Study (MDCS), higher PDF and lower systemic low-grade chronic inflammation (SLGCI) have been associated with lower cardiometabolic morbidity and mortality. We examined associations between PDF and SLGCI in the MDCS.
Migratory birds have evolved a multitude of physiological and behavioural adaptations to reach their population-specific wintering areas during their first migration. The endogenous program encodes distance, direction and fuelling, and involves species-specific adaptations leading naïve migratory birds along highly diverse routes. While daylength has been extensively studied in relation to the ons
