Filetype
Interfacial structures on the nanoscale are crucial for a wide field of applications ranging from biological membranes in life sciences through organic solar cells and industrial coatings in soft matter to hard matter structures. The latter include thin film coatings and materials such as magnetic nanoparticles and topological structures like magnetic skyrmions. Advancing such application rests on
This article explores the processes that led to the inclusion of psychedelics under the 1971 Convention on Psychotropic Substances, a cornerstone of international drug control. Drawing on archival records, we analyze the narratives and dynamics that shaped this decision. Despite limited scientific evidence of public health dangers, concerns about psychedelics were amplified by sensationalized mediThis article explores the processes that led to the inclusion of psychedelics under the 1971 Convention on Psychotropic Substances, a cornerstone of international drug control. Drawing on archival records, we analyze the narratives and dynamics that shaped this decision. Despite limited scientific evidence of public health dangers, concerns about psychedelics were amplified by sensationalized medi
A major challenge hampering the industrial and biological exploitation of lipases is the self-limiting effect of the lipolytic reaction. Defying sustained attention throughout history, the influence of lipase catalysed lipolysis on the internal structure of thin triglyceride films has proved elusive. An in-depth understanding of the lipolysis process at the triglycerides/aqueous interface will ass
Changes in plant diversity and abundance due to land-use modifications can induce plant-pollinator trophic cascades, potentially leading to long-term shifts in pollination services. Our ability to mediate such loss of pollination services through informed landscape management is limited by insufficient understanding of long-term adaptations of wild pollinators to land-use, especially when accounti
With organic solar cells surpassing 20% efficiency, the focus is shifting toward understanding the more complex mechanisms in ternary blends. This work investigates the distinct working principles of ternary organic solar cells based on a polymer donor (D) and a nonfullerene acceptor (NFA), with a fullerene acceptor (FA) as the third component. A systematic comparison between ternary D:NFA:FA syst
Context: Organic farming aims to make agriculture more sustainable, but its sustainability benefits may be offset by lower yields compared to conventional farming. Avenues to increase organic yields have been studied extensively, but there is a lack of research using integrated approaches that consider co-variation between different organic management practices within commercial farming systems. M
BACKGROUND AND AIMS: Guideline-directed medical therapy (GDMT) for heart failure (HF) is underutilized in primary care, particularly among older adults with chronic stable HF. This prospective quality improvement study, Heart Failure in Southern Sweden (HISS), evaluated the impact of a cross-disciplinary implementation project combining cardiology and primary care expertise to enhance GDMT adheren
This pioneering volume explores complex local, global and digital contexts from the perspectives of Digital Theology.The use of and access to digital technology is highly contextual. It differs between regions, generations, classes, religious denominations, and gender. Which problems theologians claim to be important and which developments they ignore is contingent on their cultural, social, econo
Background Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition influenced by both genetic and environmental factors. Prenatal and perinatal exposures have been implicated in ASD etiology, but their influence may vary across clinical subgroups, including subgroups defined by co-occurring intellectual disability (ID). Methods We conducted a population-based case–control st
Recent advances in vibrational spectroscopy techniques have proven to be reliable, fast and operator-independent tools for extracellular vesicles (EVs) study. In an attempt to further reveal the wide potential that the vibrational spectroscopy can achieve in EV characterization, in the present study we analysed the EVs isolated from various cell lines employing Attenuated Total Reflectance Fourier
Polycyclic aromatic hydrocarbons (PAHs) of molecular mass (MM) 302 Da comprise numerous structural isomers that are of high concern for human health. Because of their multiplicity, low abundance in the environment, and limited availability of authentic standards, their occurrence, composition, and environmental health risk remain not well characterized. Here we extend the characterization of MM 30
Pimavanserin was the first US Food and Drug Administration approved antipsychotic drug that does not block D2 dopamine receptors at therapeutic doses. Pimavanserin is a selective 5-HT2A receptor inverse agonist that reduces the frequency of hallucinations and delusions associated with Parkinson disease. Despite these attributes, pimavanserin prolongs the QT interval at therapeutic doses, limiting
Transposable elements (TEs) comprise nearly half of mammalian genomes and have shaped genome architecture, chromatin organization, and transcriptional landscapes. Thanks to recent advances in long-read sequencing and functional (epi)genomics, the focus has shifted from TE families to individual TE loci, revealing widespread, locus-specific regulatory roles. While most TEs have lost the capacity to
A vertical temperature stratification normally exists in rooms during the heat-ing season in cold climates. An expression of the gradient in apartments heated by hydronic radiator heating systems with exhaust ventilation has ear-lier been developed assuming a dependency of the outdoor temperature. The expression was used by a public real estate owner when re-calculating meas-ured indoor temperaturA vertical temperature stratification normally exists in rooms during the heat-ing season in cold climates. An expression of the gradient in apartments heated by hydronic radiator heating systems with exhaust ventilation has ear-lier been developed assuming a dependency of the outdoor temperature. The expression was used by a public real estate owner when re-calculating meas-ured indoor temperatur
The visual world projects a complex and rapidly changing image onto the retina of many animal species. This presents computational challenges for those animals reliant on visual processing to provide an accurate representation of the world. One such challenge is parsing a visual scene for the most salient targets, such as the selection of prey amid a swarm. The ability to selectively prioritize pr
Human bone marrow stromal cells are key elements of the hematopoietic environment and they play a central role in bone and bone marrow physiology. However, how key stromal cell functions are regulated is largely unknown. We analyzed the role of the immediate early response transcription factor EGR1 as key stromal cell regulator and found that EGR1 was highly expressed in prospectively-isolated pri
We demonstrate the generation and in-situ measurement of the electric field and CEP of intense near-single-cycle laser pulses using the new optical technique of CEP dispersion-scan.
Background and aims: We have previously found increased levels of the cysteine protease legumain in plasma and plaques from patients with carotid atherosclerosis. This study further investigated legumain during acute cardiovascular events. Methods: Circulating levels of legumain from patients and legumain released from platelets were assessed by enzyme-linked-immunosorbent assay. Quantitative PCR
Background: Early trials have reported a beneficial effect from tamoxifen treatment in patients with unresectable pancreatic cancer, in particular in women. However, the presence and prognostic significance of female hormone receptors in pancreatic or other periampullary cancers has not yet been described. Methods: Immunohistochemical screening of normal and malignant pancreatic tissue revealed t
