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Background Studies on the survival of patients with home mechanical ventilation (HMV) are sparse. We aimed to analyse the impact of controlled hypercapnia on survival over 27 years among patients with HMV in Sweden. Study design and methods Population-based cohort study of adult patients starting HMV in the Swedish Registry for Respiratory Failure (Swedevox) during 1996–2022 cross-linked with the
OBJECTIVES: To compare sociodemographic, clinical, and suicide-specific characteristics between younger old (aged 65-74) and older old (aged 75+) adults who died by suicide in 2015, and to identify clinically relevant subgroups in the entire study cohort 65+ through cluster analysis.DESIGN: Retrospective cohort study.SETTING: All health care units across Sweden.PARTICIPANTS: Individuals aged 65+ w
Anaerobic digestion (AD) of wastes and residues is a widely applied and explored process. However, when the process is not optimized, inadequate concentrations of nutrients and inhibitory compounds are common and can lead to low maximum organic loading rates and increased risk of process problems, low organic dry solids degradation rate and reduced methane yields. To overcome process instability a
The aim of the study was to investigate the prevalence of faecal carriage of extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae among residents living in nursing homes and to compare it with a corresponding group of elderly people living in their own homes.
Commitment to involuntary care is a multistage process comprising many different aspects; legal, psychological, medical, social and ethical among others. It can also be analyzed from the perspective of a continuum starting from the report to the social authorities, the evaluations on whether to commit or not, the actual commitment and aftercare following involuntary treatment. Enhancing knowledge
The ruptured anterior cruciate ligament (ACL) leads to immediate symptoms that severely affect the individual and receives great attention among the scientific community, yet there is still no consensus on the optional form of treatment. An ACL injury is also a well known high risk factor for the development of knee osteoarthritis (OA) some decades later. Knee OA development after an ACL injury is
Background: Traffic emissions including diesel engine exhaust are associated with increased respiratory and cardiovascular morbidity and mortality. Controlled human exposure studies have demonstrated impaired vascular function after inhalation of exhaust generated by a diesel engine under idling conditions. Objectives: To assess the vascular and fibrinolytic effects of exposure to diesel exhaust g
The reliability and validity of the self-report questionnaire How I Think (HIT), designed to assess self-serving cognitive distortions related to antisocial behavior, was tested among Swedish offender and nonoffender adults and adolescents (N = 364). The results showed self-serving distortions to be more common among offenders and to predict self-reported antisocial behavior when tested among adul
Background: In recent years, research on the association between physical environments and cardiovascular disease outcomes has gained momentum with growing attention being paid to Geographic Information Systems (GIS). This nationwide study is the first to examine the effect of neighbourhood physical environments on individual-level stroke, using GIS-based measures of neighbourhood availability of
Popular Abstract in Swedish Till processindustrin räknar man bland annat fabriker som tillverkar papper, plast och livsmedel. I en enda fabrik kan det finnas tusentals PID-regulatorer som har till uppgift att styra storheter som tryck, flöden och temperaturer till önskade värden. PID-regulatorns roll i processindustrin har därför jämförts med den arbetsmyran har i myrstacken. Huruvida en enskild mA large process industry can have somewhere between five hundred and five thousand control loops, and PID controllers are used in 90–97% of the cases. It is well-known that only 20–30% of the controllers in the process industry are tuned satisfactorily, but with the methods available today it is considered too time-consuming to optimize each single controller. This thesis presents tools for analys
The European spruce bark beetle is considered as one of the most destructive forest insects to Norway spruce trees in Europe. Climate change may increase the frequency and intensity of bark beetle outbreaks. It is therefore of vital importance to detect the bark beetle outbreaks and take it under control to prevent further damages. Remote sensing techniques may provide a cost-efficient solution to
Background: Ambulatory oxygen therapy is prescribed for patients with chronic lung diseases who experience exertional hypoxemia. However, available devices may not adequately meet user requirements, and their performance characteristics are heterogeneous. Objective: This study aims to identify devices available for delivery of ambulatory oxygen therapy, the technologies that they use to generate o
This reflective commentary, based on long-term experience in UK higher education, proposes a novel approach to using a wicked problem model to develop policy and practice within higher education. The aim of this approach is to reframe the narrative of strategic development to acknowledge the complexity of cultural change and the importance of stakeholder consultation to build trust, moving away fr
Atherosclerosis is a chronic inflammatory disease characterized by the entrapment of apolipoprotein B– containing lipoproteins in the arterial intima, leading to local inflammation. T helper (Th) cell 1–mediated immune responses have been associated with atherosclerosis, and the cytokine interleukin-25 (IL-25 or IL-17E) has been reported to potentially regulate Th1 cell– and Th17 cell–related immu
This thesis encompasses an introductory part and five papers related to developing techniques and phantoms required for the further growth of photoacoustic imaging (PAI). In PAI, images are created by detecting acoustic waves followed by the absorption of laser light, enabling high spatial resolution while maintaining high optical contrast. Due to the distinct absorption patterns of various chromo
We present experimental data for a vertical, 22-nm-diameter InAs/(In)GaAsSb nanowire Tunnel Field-Effect Transistor that exhibits the highest reported I60 of 1.2 μA/μm , paving the way for low power applications. The transistor reaches a minimum subthreshold swing of 43 mV/dec at VDS = 300 mV with a sub-60 mV/dec operation over a wide current range. Combined with a high transconductance of 205 μS/
Background: The optimal timing of oral anticoagulation for prevention of early ischaemic stroke recurrence in people with acute ischaemic stroke and atrial fibrillation remains uncertain. We aimed to estimate the effects of starting a direct oral anticoagulant (DOAC) early (≤4 days) versus later (≥5 days) after onset of ischaemic stroke. Methods: For this systematic review and meta-analysis we sea
Background: Exertional breathlessness is a cardinal symptom of people with chronic airflow limitation (CAL) and can be evaluated using cardiopulmonary exercise testing (CPET). Research Question: Does abnormally high exertional breathlessness in relationship to the rate of oxygen uptake (V′O2) and minute ventilation (V′E) indicate different underlying pathophysiologic mechanisms and clinical charac
