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Cholesterol-rich clusters of SNARE (soluble NSF attachment protein receptor) proteins have been implicated as being important for exocytosis. Here we demonstrate the significance of cholesterol for normal biphasic insulin secretion in mouse beta cells by removal of cholesterol from the plasma membrane using methyl-beta-cyclodextrin (MBCD). Maximal inhibition of insulin secretion in static incubati
Inflammation influences several steps of adult neurogenesis, but whether it regulates the functional integration of the new neurons is unknown. Here, we explored, using confocal microscopy and whole-cell patch-clamp recordings, whether a chronic inflammatory environment affects the morphological and electrophysiological properties of new dentate gyrus granule cells, labeled with a retroviral vecto
Policies that facilitate sustainability transformations require knowledge about the dynamics of complex socio-ecological systems, including biophysical mechanisms and diverse human-nature relationships. Such a comprehensive evidence base can only be built by integrating multiple types of knowledges. Ontology, epistemology, and semantics are a well-established terminology to structure and facilitat
Youth are one of the nine major groups of civil society for sustainable development formalized by Agenda 21. The Major Group of Children and Youth is an active independent mechanism facilitating youth involvement in the United Nations system. Youth representatives from various organizations increasingly engage in global sustainability politics but face challenges such as financial constraints, tok
Brandskum som innehåller per- och polyfluorerade ämnen (PFAS), på engelska Aqueuous Film Forming Foam (AFFF), är en av de främsta källorna till föroreningarna i Sverige. Grundvattenförorening orsakat av användandet av AFFF under brandövningar har undersökts i Kallinge, Blekinge. I området har grundvattnet använts som råvatten vilket resulterat i förhöjda halter av PFAS i dricksvattnet. Liknande faAqueuous Film Forming Foam (AFFF) containing Perfluoroalkyl and Polyfluoroalkyl Substances (PFAS) is one of the major sources of groundwater contamination in Sweden. Groundwater contamination caused by the use of AFFF in correlation to fire training events was investigated in Kallinge, Sweden. At the site groundwater was previously used as a drinking water source consequently affecting the inhabit
En vetenskaplig text i vilken jag på engelska och för en internationell läsarkrets presenterar de centrala forskningsresultaten och slutsatserna från min avhandling.
While the 8.2 ka abrupt cooling event is increasingly recognised as a major Holocene climatic anomaly, archaeological discussions of its cultural consequences have often been framed in terms of societal distress, including the collapse and abandonment of settlements. However, prehistoric communities must have responded in more diverse ways. This paper investigates the site-based socio-ecological a
Purpose of the Review: Recent insights into extracellular vesicles (EVs) derived from platelet (PC) and red blood cell concentrates (RBC), which form during blood product processing and storage. Recent Findings: EVs impact transfusion outcomes by modulating immune and inflammatory responses. Acting as lipid mediators and expressing adhesion molecules, EVs contribute to immune signaling via cytokin
HfO2, one of the most common materials in resistive switching devices, can stabilize in a ferroelectric orthorhombic phase, enabling two nonvolatile polarization states via oxygen displacement in the unit cell. Under certain conditions, ferroelectric and resistive switching can coexist, independently addressable, within one device. This study employs operando spectroscopic analysis to elucidate th
Many people use conspiracy theories to make sense of a changing world and its ever more complexif social structures (e.g., international financial systems, global bodies of governance), tragic events (e.g., terrorist attacks, man-made catastrophes, or natural disasters), or socio-political and economic issues (e.g., security, migration, distribution of resources, health care). The widespread flour
Since the late 1990s, researchers have been predicting that the era of neutrality in aid politics is coming to an end and that foreign organizations will have to take a more engaged stance. Yet while the boundaries between humanitarianism and development are fading, in some cases the neutrality norm is actually expanding rather than giving way to an engaged paradigm. Recognizing that the principle
Background and aims: After aortic coarctation (CoA) repair, patients still suffer from cardiovascular complications. The aim of this study was to measure cardiovascular markers, intima-media thickness (IMT) and plaques in controls and patients with CoA. Methods: Sixty-four patients with CoA (66% male, mean age 48 ± 15 years) and controls (54% men, mean age 47 ± 16 years) underwent ultrasound of th
Background. In some situations, and particularly when intoxications are suspected, it would be advantageous if medicines and drugs of abuse could be swiftly detected in serum or urine. Material and methods. The Department of Clinical Pharmacology at St. Olav University Hospital has since 2004 been developing a comprehensive toxicology service (at all hours 7-days/week) for immediate quantitative a
Over the past fifteen years, Hip Hop–based education has gained ground in academic literature, especially so by building on the educational tradition and gospel of Each One Teach One. A contribution to this scholarly discussion is the Scandinavian attempt to analytically tie Hip Hop education to perspectives on learning and pedagogy that traditionally derives from popular movements of the twentiet
To be a caregiver while also being next of kin is emotionally charged. This article discusses narratives of care that goes beyond what Amelia DeFalco calls “caregiving at the limit”, i.e. care necessary for basic survival. In these narratives of what we call desperate care, not only is life at stake, but the care is anxious and urgent, partly done against the will of the care recipient, and the ca
Anterior cord herniation is due to a ventral displacement of the spinal cord through a defect in the dura and/or arachnoid.1 Though the condition is rare, some case reports are available.1-3 The neurological symptoms can slowly deteriorate over several years.3 A Brown-Séquard-like syndrome is the most common presenting neurological finding.2,4 Asymptomatic cases may be discovered incidentally.4 Ho
This paper analyses the growth-inequality-poverty nexus in Tanzania. We provide a unique long-term study covering six decades of Tanzanian independence and disentangle the competing narratives concerning growth, inequality, and poverty in the country. We do this by carefully assessing the existing–and at times contradictory–data on growth, inequality, and poverty and by introducing the inequality
We study under which conditions a first-order phase transition in a composite dark sector can yield an observable stochastic gravitational-wave signal. To this end, we employ the Linear-Sigma model featuring Nf = 3, 4, 5 flavours and perform a Cornwall-Jackiw-Tomboulis computation also accounting for the effects of the Polyakov loop. The model allows us to investigate the chiral phase transition i
