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BACKGROUND: There are important unmet clinical needs to develop cell enrichment technologies to enable unbiased label-free isolation of both single cell and clusters of circulating tumor cells (CTCs) manifesting heterogeneous lineage specificity. Here, we report a pilot study based on the microfluidic acoustophoresis enrichment of CTCs using the CellSearch CTC assay as a reference modality.METHODS
Most models to predict biochemical recurrence (BCR) of prostate cancer use pretreatment serum prostate-specific antigen (PSA), clinical stage and prostate biopsy Gleason grade. We investigated whether human glandular kallikrein 2 (hK2) and free prostate-specific antigen (fPSA) measured in pretreatment serum enhance prediction. We retrospectively measured total PSA (tPSA), fPSA and hK2 in preoperat
A search for heavy resonances decaying into a W or Z boson and a Higgs boson produced in proton-proton collisions at the Large Hadron Collider at s=13 TeV is presented. The analysis utilizes the dominant W→qq¯′ or Z→qq¯ and H→bb¯ decays with substructure techniques applied to large-radius jets. A sample corresponding to an integrated luminosity of 139 fb-1 collected with the ATLAS detector is anal
Urgent structural change is required in higher education to allow collaboration both within and acrossuniversities so that achieving a rapid sustainability transition can become the overarching and mainpurpose of education, research and work in society. A review of the literature reveals that fragmentation,caused by traditional hierarchical faculty and disciplinary organisation, is a major obstacl
It is important to study the factors affecting estimates of wetness since wetness is crucial in climate change studies. The availability of digital elevation models (DEMs) generated with high resolution data is increasing, and their use is expanding. LIDAR earth elevation data have been used to create several DEMs with different resolutions, using various interpolation parameters, in order to comp
Synovial fluid was collected from patients with recent knee injury and from patients with early or late stage osteoarthritis. Chondroitin sulfate-substituted aggrecan fragments present in these fluids, and in normal bovine synovial fluid, were purified by cesium chloride gradient centrifugation, enzymically deglycosylated and fractionated by gel filtration on Superose-12. Each sample contained two
PURPOSE: The partial volume effect (PVE) is an important source of bias in brain perfusion measurements. The impact of tissue PVEs in perfusion measurements with dynamic susceptibility contrast MRI (DSC-MRI) has not yet been well established. The purpose of this study was to suggest a partial volume correction (PVC) approach for DSC-MRI and to study how PVC affects DSC-MRI perfusion results.METHOD
Purpose - The purpose of this paper is to numerically investigate the heat transfer performance of aviation kerosene flowing in smooth and enhanced tubes with asymmetric fins at supercritical pressures and to reveal the effects of several key parameters, such as mass flow rate, heat flux, pressure and inlet temperature on the heat transfer. Design/methodology/approach - A CFD approach is taken and
This article draws on socio-legal theory in relation to growing concerns over fairness, accountability and transparency of societally applied artificial intelligence (AI) and machine learning. The purpose is to contribute to a broad socio-legal orientation by describing legal and normative challenges posed by applied AI. To do so, the article first analyses a set of problematic cases, e.g. image rThis article draws on socio-legal theory in relation to growing concerns over fairness, accountability and transparency of societally applied artificial intelligence (AI) and machine learning. The purpose is to contribute to a broad socio-legal orientation by describing legal and normative challenges posed by applied AI. To do so, the article first analyzes a set of problematic cases, e.g., image
There is still a lack of pharmacological treatment options for traumatic brain injury (TBI), the dominant cause of death and disability in persons under the age of 40 in the developed part of the world. Clinical TBI is a markedly complex disease, categorized into different subtypes that differ in their pathophysiology, treatment requirements, and long-term consequences. For successful development
Purpose: This study aims to clarify the mechanism of film hole location at the span-wise direction of an internal cooling channel with crescent ribs on the adiabatic film cooling performance, three configurations are designed to observe the effects of the distance between the center of the ellipse and the side wall(Case 1, l = w/2, Case 2, l = w/3 and for Case 3, l = w/4). Design/methodology/appro
BACKGROUND AND OBJECTIVES: Degarelix is a gonadotropin-releasing hormone antagonist registered for the treatment of advanced hormone-dependent prostate cancer. Treatment causing androgen deprivation is associated with QT prolongation and this study investigated whether degarelix at supratherapeutic concentrations has an intrinsic effect per se on cardiac repolarisation and the QT interval.METHODS:
Purpose: The purpose of this study is to enhance the thermal performance in the labyrinth channel by different ribs shape. The labyrinth channel is a relatively new cooling structure to decrease the temperature near the trailing region of gas turbine. Design/methodology/approach: Based on the geometric similarity, a simplified geometric model is used. The k − ω turbulence model is used to close th
Upon ischaemic stroke, brain-resident and peripheral immune cells accumulate in the central nervous system (CNS). Interestingly, these cells express pattern specific to neurotransmitter receptors and, therefore, seem to be susceptible to neurotransmitter stimulation, potentially modulating their properties and functions. One of the principal neurotransmitters in the CNS, dopamine, is involved in t
Purpose: The study aims to focus on rotation effects on a ribbed channel of gas turbine blades for internal cooling. The combination and interaction between secondary flows generated by angled rib geometry and Coriolis forces in the rotating channel are studied numerically. Design/methodology/approach: A radially outward flow passage as an internal cooling test model with and without ribs is used
