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Multiple myeloma (MM) is an incurable malignancy of plasma cells. Epidemiological studies indicate a substantial heritable component, but the underlying mechanisms remain unclear. Here, in a genome-wide association study totaling 10,906 cases and 366,221 controls, we identify 35 MM risk loci, 12 of which are novel. Through functional fine-mapping and Mendelian randomization, we uncover two causal
More than ever, Machine Learning (ML) as a subfield of Artificial Intelligence (AI) is on the rise and is finding its way into safety-critical software applications. However, when it comes to quality assurance (QA) and trustworthiness, integrating ML models into software comes with challenges that may not be apparent at first glance. The European Union (EU) aims to tackle this problem with new reg
Background: Healthcare workers in obstetric clinics may be exposed to airborne SARS-CoV-2 when treating patients with COVID-19.Method: In this study, performed during the midst of the pandemic, air samples werecollected in delivery rooms during childbirth and analysed for SARS-CoV-2 RNA content.Result: Six of 28 samples collected inside delivery rooms were positive for SARS-CoV-2, but none in ante
In an increasingly mobile world, transience is becoming the norm. Sustainable community food initiatives, therefore, must organise to withstand high turnover of volunteers. Using a case study of the United Kingdom's National Union of Students' food growing scheme in universities, this paper aims to map the causes and effects of short-term, irregular, and low participation using a causal loop diagr
The t(14;19)(q32;q13) is a rare recurring translocation found in B-cell lymphoproliferative malignancies, involving the Bcl-3 gene. This chromosomal translocation is often found in patients under the age of 50 and causes a more progressive disease. The Bcl-3 gene encodes a protein belonging to the IκB family of proteins, which tightly regulates NFκB signaling by acting as an activator or repressor
Persons with type 2 diabetes born in the regions of famine exposures have disproportionally elevated risk of vision-threatening proliferative diabetic retinopathy (PDR) in adulthood. However, the underlying mechanisms are not known. In the present study, we aimed to investigate the plausible molecular factors underlying progression to PDR. To study the association of genetic variants with PDR unde
Monitoring a microservice system may bring a lot of benefits to development teams such as early detection of run-time errors and various performance anomalies. In this study, we explore deep learning (DL) solutions for detection of anomalous system's behavior based on collected monitoring data that consists of applications' and systems' performance metrics. The study is conducted in a collaboratio
Objective: To investigate the effects of fever therapy compared with no fever therapy in a wide population of febrile adults. Design: Systematic review with meta-analyses and trial sequential analyses of randomised clinical trials. Data sources: CENTRAL, BIOSIS, CINAHL, MEDLINE, Embase, LILACS, Scopus, and Web of Science Core Collection, searched from their inception to 2 July 2021. Eligibility cr
INTRODUCTION: The main objective was to present characteristics and outcome of patients without sustained field return of spontaneous circulation (ROSC) transported to hospital with ongoing cardiopulmonary resuscitation (CPR). Our secondary objectives were to investigate hospital-based interventions and the performance of the universal Termination of Resuscitation-rule (uTOR).METHODS: In this retr
Children born to occupying soldiers during or after conflicts are in many ways an extraordinarily vulnerable population. These so-called children born of war (CBOW) commonly inherit the stigma of transgression and foreignness from their respective parents and face discrimination in post-conflict societies. Their specific vulnerabilities, though, emerge from multiple overlapping factors: the needs
Achieving CRISPR Cas9-based manipulation of mitochondrial DNA (mtDNA) has been a long-standing goal and would be of great relevance for disease modeling and for clinical applications. In this project, we aimed to deliver Cas9 into the mitochondria of human cells and analyzed Cas9-induced mtDNA cleavage and measured the resulting mtDNA depletion with multiplexed qPCR. In initial experiments, we fou
A microenvironment is an area with a specific composition of mainly extracellular matrix (ECM) components surrounding the cells. The tight interactions between matrix molecules and cells are very important, and it is now well known that the ECM components direct cell activity and function and regulate remodeling processes during both homeostasis and pathological conditions. The lung is a very comp
This paper explores the evolving landscape of regional innovation policy, focusing on the interplay between traditional cluster policies and emerging transformative agendas. Over the past decade, policy initiatives aimed at fostering place-based, collaborative innovation have proliferated. However, questions arise regarding the adequacy of existing policy tools in accommodating newer, transformati
Air pollution is a global challenge impacting the lives of millions of people, especially in low-income countries. Improving air quality is linked to several of the United Nations Sustainable Development Goals (SDGs). The state of particulate matter (PM) pollution in Ethiopia and the importance of a national ambient air quality monitoring program are discussed. The contributions of NASA’s upcoming
Deliverable 8.8 Project WaterAgri
Background: Electroconvulsive therapy (ECT) is an effective treatment for depression with potential transient cognitive side effects. However, subjective memory impairment can extend over a long period after ECT. Objectives: This study aimed to assess potential risk factors for long-term subjective memory impairment 6 months after ECT and to explore if the associations are mediated by depressive s
INTRODUCTION: Long-term survival following lung transplantation (LTx) faces impediments due to chronic lung allograft dysfunction (CLAD), while infections hinder short-term survival. Fungal colonization and invasive fungal infections (IFI) are common within the first year after LTx. There is ongoing debate regarding the impact of such events on CLAD development and mortality. This study aims to in
