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Tumor hypoxia plays a critical role in cancer progression and therapeutic resistance. Here, we present a protocol for the self-generation of hypoxia by metastatic cancer cells using phosphorescence-based O2 sensing. We describe steps for phosphorescent film calibration, system assembly, and real-time imaging of hypoxia development. We then detail approaches to spatially map resulting O2 gradients.
The rapid proliferation of data across diverse fields has accentuated the importance of accurate imputation for missing values. This task is crucial for ensuring data integrity and deriving meaningful insights. In response to this challenge, we present Xputer, a novel imputation tool that adeptly integrates Non-negative Matrix Factorization (NMF) with the predictive strengths of XGBoost. One of Xp
Breast cancer is the most common type of cancer in women worldwide. Triple-negative breast cancer (TNBC) is a subtype of breast cancer that lacks the expression of the oestrogen receptor, progesterone receptor, and amplification of HER2. This subtype is the most aggressive subtype and a heterogeneous subgroup of breast cancer, making up around 10-15% of the cases, often affecting younger patients
BackgroundInflammation and tyrosine-kinases are known mediators in the pathobiology of cardiovascular disease. Plasma biomarkers reflecting these systems may provide a noninvasive complement reflecting hemodynamics, aiding in clinical decision-making. We therefore aimed to investigate the plasma levels of vascular and inflammatory proteins, and their associations with invasive hemodynamics in adva
Objectives: We aimed to describe the cardiopulmonary function during exercise and the health-related quality of life (HRQoL) in patients with a history of COVID-19 pneumonia, stratified by chest computed tomography (CT) findings at baseline. Methods: Among 77 consecutive patients with COVID-19 who were discharged from the Pulmonology Ward between March 2020 and April 2021, 28 (mean age 54.3 ± 8.6
Background: Rare variants of the triggering receptor expressed on myeloid cell 2 (TREM2) gene are strong risk factors for Alzheimer’s disease (AD), and drugs targeting the TREM2 protein are being developed. However, it is unknown what the effect of TREM2 variants is on the AD phenotype. Methods: Here we studied a full range of clinical and biomarker measures in a large cohort of TREM2 variant carr
BACKGROUND: Medical students navigate a complex landscape of digital tools with potential to enhance learning. The main objectives of the current study were to investigate which digital resources are being used, which background factors are associated with utilization, perceived advantages and disadvantages of different digital resources, and explore future directions.METHODS: Cross-sectional, nat
Objective: To analyze the outcomes of urgent/emergent endovascular aortic repair of patients with free/contained ruptured thoracoabdominal aortic aneurysms (rTAAA). Background: Endovascular repair of rTAAA has been scarcely described in emergent setting. Methods: An international multicenter retrospective observational study (ClinicalTrials.govID:NCT05956873) from January 2015 to January 2023 in 6
Background: Keeping the umbilical cord intact the first minutes after delivery is beneficial for both term and preterm infants. However, this may be challenging in caesarean sections (CS) due to lack of mobile resuscitation equipment, maintenance of sterility or concern for excessive maternal blood loss. The objective of this study was to develop and pilot-test extra-uterine placental transfusion
We hypothesize that predictable variations in environmental conditions caused by night/day cycles created opportunities and hazards that initiated information dynamics central to life’s origin. Increased daytime temperatures accelerated key chemical reactions but also caused the separation of double-stranded polynucleotides, leading to hydrolysis, particularly of single-stranded RNA. Daytime solar
Background: Various plasma phosphorylated tau species have been shown to be associated with amyloid-β (Aβ) PET and Tau PET in Alzheimer’s disease (AD), but whether APOE ε4 affects the interaction between glial fibrillary acidic protein (GFAP) and phosphorylated tau (pTau), and whether a three-way interaction exists among APOE ε4, GFAP, and pTau that influences AD progression remain unclear. Method
BACKGROUND: Differences in cardiac sarcoidosis between racial groups remain understudied. Therefore, this study aims to explore race differences in patients with cardiac sarcoidosis. METHODS: We analyzed data from the Cardiac Sarcoidosis Consortium, an international registry including over 25 centers. The primary clinical outcome was a composite end point of all-cause mortality, left ventricular a
ObjectivesThis study investigates the impact of transitioning from restricted to 24/7 access to blood culture cabinets on blood culture processing.MethodA post-hoc retrospective study and a prospective laboratory simulation to evaluate the effects of delayed incubation were conducted. Data analysis evaluated clinical data comparing incubation-to-detection (ITD) and Collection-to-detection (CTD) in
Background: Hearing loss is estimated to affect more than 20% of the global population. Hearing aid fitting is a common intervention in audiological rehabilitation; however, there are still those who struggle with remaining communication difficulties that require additional intervention. The group rehabilitation program Active Communication Education (ACE) has been shown to be an effective alterna
As debates about migration increase across Europe, the questions of integration and belonging increase in urgency. This chapter explores the evolving integration landscape in Sweden through the experiences of immigrant youth. It traces the shift from a humanitarian, universalist welfare model to a conditional system where inclusion depends on cultural conformity, economic productivity and individuAs debates about migration increase across Europe, the questions of integration and belonging increase in urgency. This chapter explores the evolving integration landscape in Sweden through the experiences of immigrant youth. It traces the shift from a humanitarian, universalist welfare model to a conditional system where inclusion depends on cultural conformity, economic productivity and individu
Hard-to-heal wounds are a growing human and financial concern, constituting approximately 1–3% of the healthcare budget. Wound care is not a medical specialty and is often not prioritized within healthcare. A large portion of the cost and suffering caused by wounds has the potential to be mediated through improved knowledge and effectivised workflows. One potential way to achieve this is through t
Avfallsförebyggande handlar om effektiv produktion och genomtänkt konsumtion – inte om avfall SJU LÄRDOMAR FRÅN FORSKNINGSPROJEKTET FRÅN AVFALLSHANTERING TILL AVFALLSFÖREBYGGANDE Rapportens författare HERVÉ CORVELLEC (projektledare) Institutionen för service management och tjänstevetenskap, Lunds universitet herve.corvellec@ism.lu.se RICHARD EK Institutionen för service management och tjänsteveten
https://www.ses.lu.se/sites/ses.lu.se/files/avfallsforebyggande_mtp_slutrapport_final.pdf - 2026-07-09
Centre for Retail Research at Lund University ANNUAL REPORT | 2024 2 ANNUAL REPORT CENTRE FOR RETAIL RESEARCH AT LUND UNIVERSITY 2024 3 ANNUAL REPORT CENTRE FOR RETAIL RESEARCH AT LUND UNIVERSITY 2024 Introduction Centre for Retail Research – 2024 the final chapter This is the 11th annual report from the Centre for Retail Re- search at Lund University. It is also the last we will send. While trans
