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RIFM fragrance ingredient safety assessment, 3-methyl-1-cyclopentadecanone, CAS Registry Number 541-91-3
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p53-mediated differentiation of the erythroleukemia cell line K562
The tumor suppressor gene p53 can mediate both apoptosis and cell cycle arrest. In addition, p53 also influences differentiation. To further characterize the differentiation inducing properties of p53, we overexpressed a temperature-inducible p53 mutant (ptsp53Val135) in the erythroleukemia cell line K562. The results show that wild-type p53 and hemin synergistically induce erythroid differentiati
RIFM fragrance ingredient safety assessment, cinnamyl isobutyrate, CAS Registry Number 103-59-3
RIFM fragrance ingredient safety assessment, 2-methyl-2-pentenal, CAS Registry Number 623-36-9
RIFM fragrance ingredient safety assessment, 3-methyl-5-cyclopentadecen-1-one, CAS registry number 63314-79-4
RIFM fragrance ingredient safety assessment, ethyl octanoate, CAS Registry Number 106-32-1
RIFM fragrance ingredient safety assessment, dihydrocarvyl acetate, CAS Registry Number 20777-49-5
The existing information supports the use of this material as described in this safety assessment. Dihydrocarvyl acetate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analogs dihydrocarveol (isomer unspecified) (CAS # 619-01-2) and aceti
RIFM fragrance ingredient safety assessment, 2,7-nonadienal, (2E,7Z)-, CAS Registry Number 21662-22-6
Stem cells expanded from the human embryonic hindbrain stably retain regional specification and high neurogenic potency
Stem cell lines that faithfully maintain the regional identity and developmental potency of progenitors in the human brain would create new opportunities in developmental neurobiology and provide a resource for generating specialized human neurons. However, to date, neural progenitor cultures derived from the human brain have either been short-lived or exhibit restricted, predominantly glial, diff
Identification of infants with increased type 1 diabetes genetic risk for enrollment into Primary Prevention Trials—GPPAD-02 study design and first results
Primary prevention of type 1 diabetes (T1D) requires intervention in genetically at-risk infants. The Global Platform for the Prevention of Autoimmune Diabetes (GPPAD) has established a screening program, GPPAD-02, that identifies infants with a genetic high risk of T1D, enrolls these into primary prevention trials, and follows the children for beta-cell autoantibodies and diabetes. Genetic testin
The dynamics of red blood cells and iron status during infancy
Red blood cell (RBC) and iron status biomarkers are commonly used in clinical diagnostics. However, interpretations of infant test results are inherently challenging. Modern well-defined comparative data based on presumably healthy term-born infants have mainly been lacking and interpretations could be further complicated by interference from frequent infections. Moreover, the trends that follow w
RIFM fragrance ingredient safety assessment, p-Isopropylbenzyl acetate, CAS Registry Number 59230-57-8
The use of this material under current use conditions is supported by the existing information.This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization, as well as environmental safety. Data from the suitable read across analog, benzyl acetate (CAS # 140-11-4), show that this m
Assessing both early and late EEG patterns improves prediction of outcome after cardiac arrest
Objective: Previously proposed “synchronous EEG patterns” predict poor outcome within 24 h after cardiac arrest (CA). We investigate the prognostic performance of these early EEG predictors in addition to the late EEG predictors (>24 h) recommended in the European post-resuscitation guidelines. Methods: Observational substudy of the TTM2-trial including consecutive comatose resuscitated patients.
Two-Year Outcomes after Out-of-Hospital Cardiac Arrest: Hypothermia versus Normothermia
A Broad Survey and Functional Analysis of Immunoglobulin Loci Variation in Rhesus Macaques
Rhesus macaques (RMs) are a vital model for studying human disease and invaluable to pre-clinical vaccine research, particularly for the study of broadly neutralizing antibody responses. Such studies require robust genetic resources for antibody-encoding genes within the immunoglobulin (IG) loci. The complexity of the IG loci has historically made them challenging to characterize accurately. To ad
The cost-effectiveness of mild hypercapnia after out-of-hospital cardiac arrest : a health economic evaluation alongside the TAME study
Background: Out of hospital cardiac arrest (OHCA) is a significant public health problem associated with high mortality and high healthcare costs. The Targeted Therapeutic Mild Hypercapnia after Resuscitated Cardiac Arrest (TAME) randomised clinical trial showed that targeted mild hypercapnia did not lead to better neurologic outcomes at 6 months compared to normocapnia after OHCA. We aimed to est
Allmän-studieplan-genusvetenskap-20210311
Allmän studieplan för utbildning på forskarnivå i genusvetenskap Sida 1 av 11 Fakultetsstyrelsen ALLMÄN STUDIEPLAN FÖR GENUSVETENSKAP Diarienummer U 2021/139 2021-03-11 Allmän studieplan för utbildning på forskarnivå i genusvetenskap Allmän studieplan för utbildning på forskarnivå i genusvetenskap är fastställd av Samhällsvetenskapliga fakultetsstyrelsen 2021-03-11, dnr U 2021/139. Studier enligt
Utvecklingsplan Genusvetenskapliga Institutionen GU beslut Tillgänglig
Utvecklingsplan för utbildningar inom Genusvetenskap Sida 1 av 9 Fakultetsstyrelsen UTVECKLINGSPLAN Diarienummer STYR 2020/2207 2022-02-03 Utvecklingsplan för utbildningar inom Genusvetenskap Bakgrund Under våren 2021 utvärderades Kandidatprogrammet i genusvetenskap (180 hp), Masterprogrammet i genusvetenskap (120 hp) och de fristående kurser som ges och som tillsammans kan ligga till grund för en