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Functional outcomes associated with varying levels of targeted temperature management after out-of-hospital cardiac arrest — An INTCAR2 registry analysis

Introduction: Targeted temperature management (TTM) after out-of-hospital cardiac arrest (OHCA) has been recommended in international guidelines since 2005. The TTM-trial published in 2013 showed no difference in survival or neurological outcome for patients randomised to 33 °C or 36 °C, and many hospitals have changed practice. The optimal utilization of TTM is still debated. This study aimed to

Sunshine Policies and Murky Shadows in Europe: Disclosure of Pharmaceutical Industry Payments to Health Professionals in Nine European Countries

Relationships between health professionals and pharmaceutical manufacturers can unduly influence clinical practice. These relationships are the focus of global transparency efforts, including in Europe. We conducted a descriptive content analysis of the transparency provisions implemented by February 2017 in nine European Union countries concerning payments to health professionals, with duplicate Relationships between health professionals and pharmaceutical manufacturers can unduly influence clinical practice. These relationships are the focus of global transparency efforts, including in Europe. We conducted a descriptive content analysis of the transparency provisions implemented by February 2017 in nine European Union (EU) countries concerning payments to health professionals, with dupli

Altered aromatic amine metabolism in epileptic patients treated with phenobarbital

The fate of carcinogens differs among individuals who have different activities of drug-metabolizing enzymes that are important in activating and detoxifying carcinogens. A drug that profoundly alters the metabolism of the drugs and carcinogens is the anticonvulsive agent phenobarbital. To investigate why epileptic patients appear to have a low risk of cancer of the urinary bladder, and on the bas

The new LUCID-2 detector for luminosity measurement and monitoring in ATLAS

The ATLAS luminosity monitor, LUCID (LUminosity Cherenkov Integrating Detector), had to be upgraded for the second run of the LHC accelerator that started in spring 2015. The increased energy of the proton beams and the higher luminosity required a redesign of LUCID to cope with the more demanding conditions. The novelty of the LUCID-2 detector is that it uses the thin quartz windows of photomulti

Energieffektiv utomhusbelysning längs gångvägar för människor med särskilda behov

Utomhusbelysning i offentliga miljöer har en viktig roll i en hållbar stadsutveckling. Energieffektiv LED-belysning kan stödja mobilitet i stadsmiljöer och medverka till en ökad tillgänglighet för personer med särskilda behov. Belysningen i föreliggande studie upplevdes ge tillräcklig ljusmängd och jämnt ljus, och det gick att se bra i belysningen. Trots att LED-belysningen ökade möjligheterna til

Accessing Information in Order to Manage The Strain of a New Demanding Role : A Qualitative Study of the Next of Kin of Patients after Colorectal Cancer Surgery

Objectives: The aim of this study was to explore next of kin’s experiences of information and their information needs after the patient’s discharge for colorectal cancer surgery.Methods: Sixteen next of kin were interviewed twice during the first seven weeks after the patient’s discharge from hospital. The interviews were analysed through qualitative content analysis.Results: The participants in t

Värmestress i urbana inomhusmiljöer : Förekomst och åtgärder i befintlig bebyggelse

Denna kunskapssammanställning beskriver hur hälsoskadlig värme kan uppstå inomhus, hur den kan identifieras och vilka åtgärder som kan vidtas med fokus på fastighetsägarens ansvar. Sammanställningen är begränsad till befintliga byggnader i Sverige och inkluderar skolor, äldreboenden, lägenheter, förskolor och kontor som är icke-industriella (utan industriella processer som producerar värme). Den pThis literature review describes how heat stress can develop indoors, how it can be identified, and what actions can be taken, with a focus on property owner’s responsibilities. The review is limited to existing buildings in Sweden and includes schools, retirement homes, apartments, preschools, and non-industrial offices (those without industrial processes that produce heat). The expected climate

Prediction of good neurological outcome in comatose survivors of cardiac arrest : a systematic review

Purpose: To assess the ability of clinical examination, blood biomarkers, electrophysiology or neuroimaging assessed within 7 days from return of spontaneous circulation (ROSC) to predict good neurological outcome, defined as no, mild, or moderate disability (CPC 1–2 or mRS 0–3) at discharge from intensive care unit or later, in comatose adult survivors from cardiac arrest (CA). Methods: PubMed, E

Online Representations of Older People Generated by Public Sector Organizations

This article investigates the generation of online representations of older people by institutions. Specifically, it discusses the ways in which public sector organizations generate online representations of older people from a production perspective. This article uses the following questions to frame its analysis: What do we know about online representations of older people generated by public se

Making space in the city for diverse life worlds and temporalities : An explorative investigation of the affordance and territoriality of urban cemeteries

The urban cemetery is a built green environment that is both a place of death, belonging to the bereaved and their rituals of care and remembrance, and a recreational space, where people rest, walk their dog, jog, reflect in silence, or just pass through. Urban cemeteries and urban parks share some features and uses in that respect, but they also have very different meanings and functions. The resThe urban cemetery is a built green environment that is both a place of death, belonging to the bereaved and their rituals of care and remembrance, and a recreational space, where people rest, walk their dog, jog, reflect in silence, or just pass through. Urban cemeteries and urban parks share some features and uses in that respect, but they also have very different meanings and functions. The res

Oxygen targets and 6-month outcome after out of hospital cardiac arrest : a pre-planned sub-analysis of the targeted hypothermia versus targeted normothermia after Out-of-Hospital Cardiac Arrest (TTM2) trial

Background: Optimal oxygen targets in patients resuscitated after cardiac arrest are uncertain. The primary aim of this study was to describe the values of partial pressure of oxygen values (PaO2) and the episodes of hypoxemia and hyperoxemia occurring within the first 72 h of mechanical ventilation in out of hospital cardiac arrest (OHCA) patients. The secondary aim was to evaluate the associatio

Bispecific antibodies targeting CD40 and tumor-associated antigens promote cross-priming of T cells resulting in an antitumor response superior to monospecific antibodies

Background Indications with poor T-cell infiltration or deficiencies in T-cell priming and associated unresponsiveness to established immunotherapies represent an unmet medical need in oncology. CD40-targeting therapies designed to enhance antigen presentation, generate new tumor-specific T cells, and activate tumor-infiltrating myeloid cells to remodel the tumor microenvironment, represent a prom

Old Wood in a New Light: An Online Dendrochronological Database

The Old Wood in a New Light database project focuses on the digitization and accessibility of the results of dendrochronological samples analyzed and archived at four Swedish university-based tree-ring laboratories at Lund University, Stockholm University, University of Gothenburg, and the Swedish University of Agricultural Sciences. Collaboration with the Environmental Archaeology Laboratory and The Old Wood in a New Light database project focuses on the digitization and accessibility of the results of dendrochronological samples analyzed and archived at four Swedish university-based tree-ring laboratories at Lund University, Stockholm University, University of Gothenburg, and the Swedish University of Agricultural Sciences. Collaboration with the Environmental Archaeology Laboratory and

Mellan Pod och Patient – hur förändras arbetet när vården blir digital, slutrapport

Teknikutvecklingen inom e-hälsoområdet möjliggör ständigt nya och mer avancerade arbetssätt för att övervaka och vårda patienter digitalt. Vården sker då genom kontinuerlig övervakning av patientens hälsa via digitalt överförda data och kommunikation mellan vårdpersonal och patient där feedback och rekommendationer skräddarsys efter patientens behov och tillstånd. Denna typ av digital vård är ett

Live well, die well - an international cohort study on experiences, concerns and preferences of patients in the last phase of life: the research protocol of the iLIVE study

Introduction Adequately addressing the needs of patients at the end of life and their relatives is pivotal in preventing unnecessary suffering and optimising their quality of life. The purpose of the iLIVE study is to contribute to high-quality personalised care at the end of life in different countries and cultures, by investigating the experiences, concerns, preferences and use of care of termin

RIFM fragrance ingredient safety assessment, allyl (cyclohexyloxy)acetate, CAS registry number 68901-15-5.

The use of this material under current use conditions is supported by the existing information. This material was evaluated for Genotoxicity, Repeated Dose Toxicity, Developmental Toxicity, Reproductive Toxicity, Local Respiratory Toxicity, Phototoxicity, Skin Sensitization potential as well as Environmental assessment. Repeated dose toxicity was determined to have the most conservative systemic e

Anpassning till rådande ordning. En studie av manliga förskollärare i förskoleverksamhet

Popular Abstract in Swedish Under de senaste decennierna har förhoppningar om en ökad andel manlig personal i förskolans verksamhet uttryckts från samhällets sida. Förhoppningarna har dock inte infriats och antalet yrkesverksamma manliga förskollärare var cirka två procent i slutet av 1990-talet. Denna könsmässigt underrepresenterade grupp, som i sin yrkesutövning befinner sig i en kraftigt könsmäThe aim of this study is to describe and analyse the situation of male teachers in the day-to-day work of pre-school, taking into account the fact that men are underrepresented in this profession. The methodic field is qualitative. Video recordings and interviews have been carried out with the fourteen male pre-school teachers who have participated in the project. Some of these men work together w

A Landscape of Left-Overs : Changing Conceptions of Place and Environment among Mi'kmaq Indians of Eastern Canada

Popular Abstract in Swedish I september 1989 kom det till kanadensiska mi’kmaqindianers kännedom att ett enormt granitbrott (ett av de tre största i världen) planerades att öppnas vid Kellys Mountain på ön Cape Breton i östra Kanada. Mi’kmaqtraditionalister organiserade genast en fredlig trumceremoni på berget och en talesman deklarerade att det planerade granitbrottet var en förolämpning mot bådeThis dissertation seeks to explore historical changes in the lifeworld of the Mi’kmaq Indians of Eastern Canada. The Mi’kmaq culture hero Kluskap here serves as a key persona in discussing issues such as traditions, changing conceptions of land, and human-environmental relations. In order not to depict Mi’kmaq culture as timeless, two important periods in its history are examined. The first study