Filetype
Combining long-acting muscarinic antagonists (LAMAs) and long-acting β2-agonists (LABAs) is beneficial in chronic obstructive pulmonary disease (COPD), as the two classes of bronchodilator have complementary modes of action. The optimal dose for the fixed-dose combination of the LAMA tiotropium and the LABA olodaterol needed to be determined. In this phase II trial, the dose response of tiotropium
A disadvantage of prostate-specific antigen (PSA) for the early detection of prostate cancer (PCa) is that many men must be screened, biopsied, and diagnosed to prevent one death.
Popular Abstract in Swedish Proteoglykaner (PG), framför allt sådana som bär glykosaminoglykan-sidokedjor av heparansulfat (HS) typ, utgör multifunktionella receptorer på cellytan och i pericellulär matrix hos alla adherenta celler i högre organismer. HS-proteoglykaner är inblandade i många olika cellprocesser, bl.a. koagulation, celltillväxt, och aktivering av enzymer, antienzymer samt bindning t
Waist circumference (WC) and waist-to-hip ratio (WHR) are surrogate measures of central adiposity that are associated with adverse cardiovascular events, type 2 diabetes and cancer independent of body mass index (BMI). WC and WHR are highly heritable with multiple susceptibility loci identified to date. We assessed the association between SNPs and BMI-adjusted WC and WHR and unadjusted WC in up to
To examine the association of sialic acid (SA) with first recorded diabetes mellitus-related hospitalization.
Purpose: The primary aim was to analyse regional incidences of retinopathy of prematurity (ROP) and frequencies of treatment and their relation to perinatal risk factors during a 3-year period. A secondary aim was to study adherence to the study screening protocol in the different regions. Methods: A population-based study of neonatal morbidity in extremely preterm infants in Sweden (EXPRESS) was
The transcription factor STAT3 is a potential target for the treatment of castration-resistant prostate cancer. Galiellalactone (1), a direct inhibitor of STAT3, prevents the transcription of STAT3 regulated genes. In this study we characterized 6 (GPA512, Johansson, M.; Sterner, O. Patent WO 2015/132396 A1, 2015), a prodrug of 1. In vitro studies showed that 6 is rapidly converted to 1 in plasma
Background: The globalisation of the economy and the labour markets has resulted in a growing proportion of individuals who find themselves in a precarious labour market situation, especially among the young. This pertains also to the Nordic countries, despite their characterisation as well developed welfare states with active labour market policies. This should be viewed against the background of
Obese individuals are more likely to develop heart failure. Yet, once heart failure is established, the impact of overweight and obesity on prognosis and survival is unclear. The purpose of this joint scientific statement of the European Association for the Study of Obesity and the European Society of Hypertension is to provide an overview on the current scientific literature on obesity and heart
Elevated cystatin C in blood reflects impaired glomerular filtration rate (GFR), but current cystatin C assays, based on polyclonal antibodies and immunoturbidimetric or nephelometric detection, have several limitations. We evaluated a new immunoassay based on monoclonal antibodies in samples from patients with and without chronic kidney disease (CKD). The study enrolled 170 men without known CKD
Denna uppsats argumenterar för behovet av mer forskning, förståelse och medvetenhet kring destruktiva konsekvenser av ledarskap. Företag drabbas i dag av nedskärningar, stora förändringar och hög grad av arbetsbelastning. Dessa faktorer skapar tillsammans en grogrund för mellanmänskliga konflikter inom företagen, varför ledarskap får sig en allt större och mer betydelsefull roll. Genom att utforsk
Representationskompetensen hos den verkställande direktören i svenska aktiebolag regleras genom 8 kap. 36 § ABL och därigenom rekvisitet ”löpande förvaltning” i 8 kap. 29 § ABL. Vad denna löpande förvaltning omfattar är dock inte helt tydligt och kan variera kraftigt mellan olika typer av bolag och situationer. Detta kan skapa såväl praktiska som juridiska problem för både bolag och den verkställaThe legal capacity for Chief Executive Officers (CEO) in Swedish corporations is regulated through the legal condition “everyday operations” in Chapter 8, 36 § of the Swedish Companies Act of 2005. What is meant with “everyday operations” is not completely clear and can vary massively between different kinds of companies and situations. This may cause problems from both a practical and a jurisdict
Over three-quarters of the world’s poor live in rural areas and many of them depend on agriculture to earn a living. In a context of climate change, Agriculture, Forestry and Other Land Use (AFOLU) is addressed as one of the main sources of Greenhouse Gas (GHG) emissions. Hence, the sustainability transition in the agricultural sector has become one of the most prominent development areas in the 2
Studiens syfte är att få fram hur FN ser på sexuella övergrepp som utförs av deras egen personal. Jag har utfört en diskursanalys utifrån frågeställningarna om det pågår ett förebyggande arbete inom FN för att stoppa sexuella övergrepp och hur FN talar om övergreppen och förövarna. Teorin jag använder mig av är R. W. Connells teori om maskulinitet som utgår från tre relationstyper och fyra maskuli
Den här uppsatsen tar upp innehållsstrukturens betydelse för översättningen av några inledande kapitel av Fernando Savaters bok Las preguntas de la vida. Uppsatsen inleds med en textanalys som följer analysmodellen i Hellspong & Ledin (1997). Därefter följer uppsatsens huvuddel som består dels av en genomgång av textens hierarkiskt ordnade innehåll och dels av exempel på hur denna innehållsstr
We used a southern Swedish cohort of psoriasis (PSO) and psoriatic arthritis (PsA) patients and population-based referents (N = 57,800) to investigate the influence of socioeconomic and demographic factors on the probability of healthcare use and on healthcare costs when controlling for need as measured by PSO/PsA and common additional morbidities such as diabetes, depression and myocardial infarc
