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BackgroundWorkplace sexual harassment remains a persistent issue in Sweden. Research about organisational antecedents has been criticised for being limited in scope, possibly overlooking contextual factors relevant for the occurrence of sexual harassment. This study examined two factors capturing aspects of organisational climate, perceived relational justice and authoritarian treatment, and their
BACKGROUND: – The clinical use of risk scores to guide treatment decisions and improve clinical outcomes has rarely been prospectively evaluated. This study aimed to evaluate whether a biomarker-based ABC-AF risk score–guided multidimensional treatment strategy improves long-term outcomes in patients with AF. METHODS: – The multicenter, registry-based, randomized, controlled, open-label study enro
Background: Co-occurring substance use disorders, and mental disorders are associated with significant suffering, high risks of violent reoffending and relapse in both substance use and psychotic episodes. Treatment for co-occurring substance use disorders in forensic mental health settings would benefit from incorporating patients’ understanding of their disorders. Method: Using an interpretative
Background: Wrist osteoarthritis can cause persistent pain, reduced joint mobility, and difficulty performing daily activities, negatively impacting quality of life. Although patient education and exercise therapy are recommended as first-line treatments for osteoarthritis in other joints, evidence supporting these strategies for wrist osteoarthritis remains limited. This randomized controlled tri
Objective: To investigate whether baseline use of pain medication is associated with program adherence during a three-month digital treatment program for individuals with hip or knee osteoarthritis (OA). Design: An observational cohort study using registry data on weekly participant adherence from 33078 participants enrolled in a digital education and exercise therapy program. Poor adherence was d
The present study aimed to increase understanding of how singing activities may be initiated in primary school, and what support and assistance teachers require to conduct singing activities as an integrated part of the school day. Five music teachers participated in a focus group interview. The following main themes were identified: 1) pedagogical and methodological flexibility, 2) the role of ro
Background: Alcohol use disorder (AUD) is associated with an enormous burden of disease and cost to society. The dopamine deficiency hypothesis posits that negative reinforcement generated by a low brain dopamine state drives ethanol intake. Here, we evaluated the efficacy and safety of combined administration of two dopamine-enhancing drugs, varenicline (a partial nicotinic acetylcholine receptor
BACKGROUND: Brain-derived neurotrophic factor (BDNF) plays a critical role in neuronal development and neural connectivity, and has been implicated in the pathophysiology of Major Depressive Disorder (MDD). However, its predictive value for MDD onset remains unclear. This study examined whether baseline BDNF levels are associated with incident MDD in middle-aged women.MATERIAL AND METHODS: In this
BACKGROUND: This study aimed to evaluate the prevalence of pathogenic/likely pathogenic cardiomyopathy variant carriers in a multiancestry US population and examine the risk of adverse clinical outcomes. METHODS: This retrospective cohort study included multiancestry US adults aged ≥18 years with sequencing data from the All of Us Research Program. Pathogenic/likely pathogenic variants in cardiomy
OBJECTIVE: This study evaluated the effects of a 6-week osteoarthritis (OA) exercise and education intervention on metabolic health markers, including blood pressure (BP), glycated haemoglobin (HbA1c), high-density lipoprotein (HDL), cholesterol levels and weight in individuals with both OA and diabetes.METHODS: Data originated from the Swedish Osteoarthritis and Diabetes cohort, which is composed
Background: It is not known whether stromal cells in benign breast tissue can mediate risk of breast cancer. We recently described aldehyde dehydrogenase 1 A1 (ALDH1) positive (+) cells in morphologically normal breast stroma of premenopausal women, and the data indicated that their distribution is associated with clinical risk factors for breast cancer. The aim of the present study was to define
Macronutrient intake, the proportion of calories consumed from carbohydrate, fat, and protein, is an important risk factor for metabolic diseases with significant familial aggregation. Previous studies have identified two genetic loci for macronutrient intake, but incomplete coverage of genetic variation and modest sample sizes have hindered the discovery of additional loci. Here, we expanded the
BACKGROUND: Comparable data on the global and country-specific burden of neurological disorders and their trends are crucial for health-care planning and resource allocation. The Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study provides such information but does not routinely aggregate results that are of interest to clinicians specialising in neurological conditions. In this syst
Current distance measurement techniques for pulse wave velocity (PWV) calculation are susceptible to intercenter variability. The aim of this study was to derive and validate a formula for this distance measurement. Based on carotid femoral distance in 1183 whole-body magnetic resonance angiograms, a formula was derived for calculating distance. This was compared with distance measurements in 128
An N-heterocyclic carbene palladium(II) complex containing two anthracene side arms was immobilized on the surface of reduced graphene oxide (rGO) by π-stacking. The activity of the homogeneous analogue and the supported complex in undirected C–H acetoxylation reaction of arenes was studied. The results show that the catalytic efficiency in acetoxylation of benzene is improved in the immobilized m
Active surveillance (AS) is broadly described as a management option for men with low-risk prostate cancer, but semantic heterogeneity exists in both the literature and in guidelines. To address this issue, a panel of leading prostate cancer specialists in the field of AS participated in a consensus-forming project using a modified Delphi method to reach international consensus on definitions of t
The amount and quality of greenness in the local outdoor environment has repeatedly been linked to human well-being. Different types of green areas are likely required in order to meet the various needs of people throughout the course of their lives and with regard to individual social and economic living conditions. The aim of the present study was to increase the understanding of different pathw
