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Urinary Biomarkers and Patient Outcome in Chronic Kidney Disease and Atherosclerotic Heart Disease: The value of IgM-uria and IgG-uria

Risk stratification of patients with chronic kidney disease and atherosclerotic heart disease is crucial. Microalbuminuria (MA) is associated with an increased risk of kidney and cardiovascular (CV) death, especially in patients with diabetes. However, MA in many instances is not sensitive for disease outcome; for instance, not all diabetic patients with albuminuria progress to kidney failure, and

Clinical and experimental studies on wear and osteolysis in total joint replacement

Popular Abstract in Swedish Total höftledsplastik är en vanlig och mycket framgångsrik behandling av smärttillstånd i höftleden. Enligt svenska höftplastikregistret opererades 12651 patienter år 2002 men 1056 patienter fick samma år genomgå ett utbyte av sin höftledsprotes (revision). Att höftleden vrids ur led (luxation) upprepade gånger eller infektion kan vara orsaken till revision men det vanlTotal hip arthroplasty is a very successful procedure. Despite this fact, however, a certain portion of patients has to be revised. One major reason for revision is the wear of the polyethylene leading to loosening and osteolysis. The overall aim of this thesis was to evaluate linear wear and migration of cemented, all - polyethylene sockets and polyethylene liners in total hip arthroplasty. The a

Molecular and morphological studies on non-healing venous leg ulcers.

Popular Abstract in Swedish Den övergripande målsättningen med denna avhandling har varit att undersöka molekylära förändringar i icke läkande venösa bensår. Framförallt har fokus lagts på faktorer som underhåller den ständigt pågående inflammationen i venösa sår. Med tanke på att alla venösa sår alltid koloniseras av olika bakterier, har vi undersökt hur bakterier kan påverka sårläkning och inflaChronic skin ulcers are a major health problem and an increasing burden on health care providers. These ulcers have various underlying causes, such as venous or arterial insufficiency, diabetes, or vasculitis. Non-healing venous leg ulcers represent a condition characterized by excessive inflammation and presence of bacteria. The overall aim of this thesis has been to explore the pathogenesis of t

Higher Education for Girls in North American College Fiction 1886-1912

Twenty years after Vassar College welcomed the first American female undergraduates in 1865, the experiences of women college students began to be fictionalized in so-called college stories. This thesis shows how higher education is presented in the novels, collections of short stories, and serialized stories for female readers published before the United States was involved in the First World Wa

Health care for the elderly: two cases of technology diffusion.

Diffusion of medical technology and the growing proportion of elderly people in the population are generally regarded as major contributors to the increasing health care expenditure in the industrialised world. This study explores the importance of one specific factor in this process, the change in the use of technology among elderly patients. In some instances, a new technology is first used amon

Utvärdering av cykelfälts effekter på cyklisters säkerhet och cykelns konkurrenskraft mot bil

Popular Abstract in Swedish Cykeln som transportmedel har många fördelar för individ och samhälle. Det är ett mycket energisnålt transportmedel, det förorenar inte, bullrar inte, tar liten plats och ger dem som cyklar välbefinnande och motion. Om fler cyklade istället för att åka bil skulle detta medföra trevligare stadsmiljöer. Ökad cykling hade också kunnat bidra till en ökad folkhälsa. För närThis work presents an evaluation of bicycle lane effects on cyclist safety and the ability of bicycles to compete with car traffic. Thirteen Swedish urban streets were studied before and after bicycle lanes were introduced. Data was collected using video recordings, speed studies, road side questionnaires/interviews with cyclists/car drivers, conflict studies and accident analysis. Results showed

Nonyrast States in the Odd-odd N = Z Nucleus 62Ga

Low-lying excited states in the odd-odd N = Z nucleus 62Ga have been investigated following the heavy-ion fusion-evaporation reaction 40Ca(24Mg,pn)62Ga near the Coulomb barrier. Special emphasis is devoted to the search for nonyrast states. The extended decay scheme of 62Ga is compared to spherical shell-model calculations employing the pf5/2g9/2 valence space.

Fluorescence spectroscopy in tissue phantoms for improved depth resolution in tissue imaging

A way to determine the depth of an embedded fluorescent object, for example deep-lying tumors marked with a fluorescent probe, is to detect fluorescent light that has propagated through the medium at two different wavelength bands. A ratio can then be calculated between the corresponding intensities. The wavelength regions should be chosen such that there is a difference in the absorption in the m

Higher Education for Girls in North American College Fiction 1886-1912

Popular Abstract in Swedish Från 1865 och framåt öppnades i nordöstra U.S.A ett antal college där unga kvinnor kunde avlägga en icke yrkesinriktad akademisk examen. Efter några decennier använde några som utexaminerats från dessa institutioner sina erfarenheter i populära berättelser om studenter på college. Avhandlingen visar hur denna utbildning presenteras i skönlitterär form. Fokus ligger på Twenty years after Vassar College welcomed the first American female undergraduates in 1865, the experiences of women college students began to be fictionalized in so-called college stories. This thesis shows how higher education is presented in the novels, collections of short stories, and serialized stories for female readers published before the United States was involved in the First World Wa

L68Q cystatin C: Expression, cellular transport and turnover of the cystatin C variant forming amyloid in patients with Hereditary Cystatin C Amyloid Angiopaty (HCCAA)

Hereditary cystatin C amyloid angiopathy (HCCAA) is a disorder characterised by multiple strokes in young adults, resulting in paralysis and dementia. The disease is caused by a mutation in the gene coding for the peptidase inhibitor cystatin C. The mutation causes an amino acid substitution Leu68 -> Gln in cystatin C (L68Q cystatin C) which results in deposition of the protein in the blood vessel

Walking Along, Wandering Off and Going Astray A Critical Normativity Approach to Walking as a Situated Architectural Experience

Popular Abstract in Swedish Gående som mellanmänsklig handling Traska, spatsera, flanera, power-gå, ila, dra fötterna efter sig, ta en stärkande promenad eller bara vandra bort i tankarna för en kort stund. Att gå är en komplex handling som omfattar allt från upplevelsen av marken som vi går på till människorna vi möter. Både när vi är ute och går själva eller tillsammans med andra så förhåller vThere is a lack of attention toward the diversity in experiences of architecture that are expressed through walking. Through the application of autoethnography and critical perspectives of queer and feminist theory, this dissertation develops a method for investigating experiences of architecture in regard to the activity of walking. In addition, this thesis addresses the influence of form, materi

Bracing of steel bridges during construction; theory, full-scale tests and simulations

Popular Abstract in English Bracings are structural components that assure the stability of the load bearing structures is maintained so as a desired level of load-carrying capacity of them is achieved. The present study as a whole involves investigations of either the temporary or permanent bracings that are often required during the construction phase of steel bridges. Current knowledge concerniA number of steel bridges have suffered lateral-torsional failure during their construction due to their lacking adequate lateral and/or rotational stiffness. In most cases, slight bracing can be of great benefit to the main girders involved through their controlling out-of-plane deformations and enabling the resistance that is needed to be achieved. The present research concerned the performance

Efficient simulation of adaptive optics technologies for the Euro50 telescope

An efficient adaptive optics (AO) simulation code was developed, which enables first-order simulations of extremely high-order systems. The Monte-Carlo-type code employs a sparse conjugate gradient algorithm for wavefront reconstruction, and a separation of spatial frequencies into two domains to economize on the number crunching. High-order multi-conjugate adaptive optics (MCAO) systems are there

Code Division Multiple Element Synthetic Aperture Transmission

In conventional synthetic transmit aperture imaging (STA) the image is built up from a number of low resolution images each originating from consecutive single element firings to yield a high resolution image. This lowers the frame rate and may result in motion artifacts. This paper, describes a method in which all transmitting centers can be excited at the same time and separated at the receiver

The Defense of Superior Orders - Article 33 of the ICC statute: a departure from customary international law?

Inom internationell straffrätt har det länge debatterats huruvida försvaret att en soldat begått ett internationellt brott efter befallning av förman ska innebära ansvarsfrihet för den åtalade. Om en soldat blir beordrad av sin befälhavare att begå ett brott så står han inför ett dilemma. Han kan antingen vägra, och riskera repressalier från nationellt håll, eller begå brottet, och riskera att bliThe defence of superior orders is the answer to what is called the soldier’s dilemma. This is so called since on the one hand, a soldier is bound by national legislation, military practice, and often psychological pressure to unquestioningly follow the orders of his superior. On the other hand, when this order is illegal, he is bound by international law to refuse to follow the order. There are th

Luftledning eller markkabel -Hur ska framtidens regionnät byggas?

In my thesis I have chosen to immerse myself in the regional power line network and how it will be built. I have chosen this topic because it is a significant question today and in the future. The investments and technical choices made today, will affect the outcome on the society of tomorrow. When the local power line network was rebuilt, after the hurricane Gudrun in the year 2005, it implied a

Föräldraskap bakom skärmen - En intervjustudie med åtta småbarnsföräldrar

Studiens syfte var att nå en fördjupad förståelse av småbarnsföräldrars användande av interaktiva skärmar när de umgås med sina barn; vilken mening användandet har för individen och vilka följder detta kan få för relationen mellan förälder och barn. Semistrukturerade intervjuer genomfördes med åtta småbarnsföräldrar som sällan, ibland eller ofta använde sig av interaktiva skärmar. Tematisk analys The aim of this study was to gain a greater understanding of the usage of interactive screens by parents of young children, whilst interacting with their children; what role does the usage of interactive screens play for the individual and how does the usage affect the relationship between parent and child. Semi-structured interviews were conducted with eight parents of young children who rarely,

HIV-1, HIV-2 and other Sexually Transmitted Infections in Guinea-Bissau, West Africa

Popular Abstract in Swedish Humant immunbristvirus (HIV) orsakar förvärvat immunbristtillstånd (AIDS). HIV/AIDS-epidemin har hittills innefattat över 60 miljoner människor som har infekterats och över 30 miljoner av dessa har avlidit i AIDS. HIV-infektion smittar via blod, sexuellt och från mor till barn vid graviditet eller via bröstmjölk. Vid infektion infogas virusets arvsmassa i den infekteradHIV-1 is dominating the global HIV pandemic, while HIV-2 is mainly confined to West Africa. The highest HIV-2 prevalence figures have been reported from Guinea-Bissau. While HIV-1 infection almost invariably leads to progressive immune dysfunction and AIDS, HIV-2 infection is characterised by a smaller proportion of individuals with disease progression to AIDS. In order to monitor the long-term e