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For extremely large telescopes, there is strong need for thin deformable mirrors in the 3-4 m class. So far, feasibility of such mirrors has not been demonstrated. Extrapolation from existing techniques suggests that the mirrors could be highly expensive. We give a progress report on a study of an approach for construction of large deformable mirrors with a moderate cost. We have developed low-cos

Ur ett hundraårsperspektiv har arbetsmarknaden genomgått avsevärda förändringar. Majoriteten av löntagarna utgörs numera av tjänstemän. I Sverige svarar de även för majoriteten av fackmedlemmarna. De svenska fackföreningarna tillämpade redan tidigt en bred medlemsrekrytering, men till bilden hör också att Sverige har världens mest klassuppdelade fackliga rörelse. Inte minst för tjänstemännen har d

This dissertation concerns the field of applied psychiatry and focuses on the problems that are associated with the care and treatment of adult patients with autism spectrum disorders. The conditions that are described are valid for Swedish psychiatry and cannot be directly generalized to conditions outside of the country.

Observations based on overexpression of the suppressor gene p53 or interference with endogenous p53 support a role for p53 in mediating not only growth inhibition and apoptosis but also differentiation. The aim of this study was to characterize the mechanisms of p53-dependent differentiation in the monoblastic leukemia cell line U-937. These cells were transfected with a mutant of the p53 gene exp

New knowledge in science and engineering relies increasingly on results produced by scientific software. Therefore, knowing how scientists develop and use software in their research is critical to assessing the necessity for improving current development practices and to making decisions about the future allocation of resources. To that end, this paper presents the results of a survey conducted on

Most products are developed while adapting to requirements from industrial production and logistics. To break that trend and design for people, we suggest focusing on those who put the strongest demands on the final solution. They cannot compensate for bad design solutions and are thereby, like sniffing dogs, guiding designers to meet peoples’ needs. We always use a combination of empathic modelli

Background: Variation in the incidence, survival rate and factors associated with survival after cardiac arrest in Europe is reported. Some studies have tried to fill the knowledge gap regarding the epidemiology of out-of-hospital cardiac arrest in Europe but were unable to identify reasons for the reported differences. Therefore, the purpose of this study was to describe European Emergency Medica

PURPOSE: Pre-clinical studies have shown that ex vivo non-ischemic heart preservation (NIHP) method can be safely used for 24 hours. This state-of-the-art method has never been applied on humans. ໿໿The primary objective of the study was to evaluate the efficacy and safety of the NIHP method on early and late human heart allograft function compared with static cold storage (SCS). METHODS: We perfor

BACKGROUND: Proenkephalin A 119-159 (penKid) has been suggested as a marker of renal failure and poor outcome. We aimed to investigate the association of penKid on ICU admission with organ dysfunction and mortality in a mixed ICU population. In this retrospective, observational study, admission penKid levels from prospectively collected blood samples of consecutive patients admitted to four Swedis

BACKGROUND: Our aim was to investigate the prognostic potential of circulating dipeptidyl peptidase 3 (cDPP3) to predict mortality and development of organ dysfunction in a mixed intensive care unit (ICU) population, and for this reason, we analysed prospectively collected admission blood samples from adult ICU patients at four Swedish hospitals. Blood samples were stored in a biobank for later ba

BACKGROUND: Despite the increasing longevity of the world's population, with an unprecedented rise in the number of people who need palliative care (PC), there has been sparse research regarding palliative care for older people, especially when it comes to comparison of PC between healthcare systems and cultures. The aim of this systematic scoping review was to identify the characteristics of the

The aim of these guidelines is to provide evidence‑based guidance for temperature control in adults who are comatose after resuscitation from either in-hospital or out-of-hospital cardiac arrest, regardless of the underlying cardiac rhythm. These guidelines replace the recommendations on temperature management after cardiac arrest included in the 2021 post-resuscitation care guidelines co-issued b

Popular Abstract in Swedish Vid typ 1 diabetes har patienten ingen egen insulinproduktion, utan måste tillföra insulin via injektioner i underhudsfettet. Insulinbehovet är inte konstant, utan varierar beroende på olika faktorer, t.ex. fysisk aktivitet och födointag. Eftersom det är svårt att alltid rätt förutsäga vilken insulinmängd man behöver, varierar blodsockret (blodglukos) mer hos en insulinHypoglycaemia is an acute complication to insulin-treatment in type 1 diabetes mellitus, which affects many physiological parameters, deteriorates the cognitive function, and may lead to death. The aim of this thesis was to study nerve function, cognitive function and cerebral blood flow during and after hypoglycaemia in healthy subjects and to study certain aspects of a fall in blood glucose in p

Background: The aim of this study was to describe out-of-hospital cardiac arrest (OHCA) survivors' ability to participate in activities of everyday life and society, including return to work. The specific aim was to evaluate potential effects of cognitive impairment. Methods and Results: Two hundred eighty-seven OHCA survivors included in the TTM trial (Target Temperature Management) and 119 match

OBJECTIVES: Acute aortic dissection type A is a life-threatening condition, warranting immediate surgery. Presentation with sudden chest pain confers a risk of misdiagnosis as acute coronary syndrome resulting in subsequent potent antiplatelet treatment. We investigated the impact of dual antiplatelet therapy (DAPT) on bleeding and mortality using the Nordic Consortium for Acute Type A Aortic Diss

Pointing is a typical means of directing a human's attention to a specific object or event. Robot pointing behaviours that direct the attention of humans are critical for human-robot interaction, communication and collaboration. In this paper, we describe an experiment undertaken to investigate human comprehension of a humanoid robot's pointing behaviour. We programmed a NAO robot to point to mark