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BACKGROUND: Conventional dosages of cytostatics in mg/m2 will cause marked variations in systemic exposure, resulting in over- and under-treatment, at least with respect to side effects.PATIENTS AND METHODS: We are conducting a randomized adjuvant study for breast cancer patients younger than 60 years of age with > or = 70% risk of recurrence within five years. The first 89 consecutive patients wh

Purpose: This study aims to examine the role of gender balance in forming individuals’ understanding of entrepreneurship as manifested in the graduates’ occupational choices, asking: Does gender balance in entrepreneurship education influence start-up behaviour after graduation? Based on gender mainstreaming, this study builds on the assumption that gender balance influences classroom and student PurposeThis study aims to examine the role of gender balance in forming individuals’ understanding of entrepreneurship as manifested in the graduates’ occupational choices, asking: Does gender balance in entrepreneurship education influence start-up behaviour after graduation? Based on gender mainstreaming, this study builds on the assumption that gender balance influences classroom and student co

ackground: The separate spheres, in which men dominate the public sphere of politics, arts, media, and wage work and women dominate the private sphere of unpaid production and caring, is a powerful configuration in much social theory (including Parsons, Becker, and Goode), which posited that with industrialization, family structures and activities would converge towards the nuclear family with strBackground: The separate spheres, in which men dominate the public sphere of politics, arts, media, and wage work and women dominate the private sphere of unpaid production and caring, is a powerful configuration in much social theory (including Parsons, Becker, and Goode), which posited that with industrialization, family structures and activities would converge towards the nuclear family with st

Malaria parasites (Plasmodium spp.) include some of the world's most widespread and virulent pathogens. Our knowledge of the molecular mechanisms these parasites use to invade and exploit hosts other than mice and primates is, however, extremely limited. It is therefore imperative to characterize transcriptome-wide gene expression from non-model malaria parasites and how this varies across host inMalaria parasites (Plasmodium spp.) include some of the world's most widespread and virulent pathogens. Our knowledge of the molecular mechanisms these parasites use to invade and exploit hosts other than mice and primates is, however, extremely limited. It is therefore imperative to characterize transcriptome-wide gene expression from non-model malaria parasites and how this varies across host in

Vad är en kompetensportfölj? En samling arbetsprover som visar upp den egna kompetensen? En elektronisk plattform för dokumentlagring? En övning i reflektion och utveckling? I denna rapport samlas erfarenheter från medarbetare vid Lunds universitet som under perioden 2015–2016 har arbetat med kompetensportföljer – för studenter och lärare. Rapporten redovisar resultat från tre delprojekt: • Utveck

Ring width (TRW) chronologies from Siberian (Pinus sibirica) and Scots (Pinus sylvestris) pine trees were sampled at Mukhrino - a large mire complex in central-western Siberia - to evaluate the impacts of hydroclimatic variability on tree growth over the last three centuries. For this purpose, we compared climate-growth correlation profiles from trees growing on peat soils with those growing on ad

Den aktuella avhandlingen härrör ur forskningsinsatser inom klinikerna för onkologi och ortopedi vid Universitetssjukhuset i Lund, och behandlar vad som ursprungligen verkade vara två skilda ämnen.Ena ämnet behandlar epidemiologin för mjukdelssarkom hos vuxna (MDS), en grupp av ofta dödliga sjukdomar av okänd orsak, som behandlas av både onkologer och ortopeder. Här har den historiska oförmågan at

Syftet med studien är att undersöka den förbättrade upptagningen av det radioaktiva spåret Technetium-99m-DTPA (99mTc-DTPA) i råtta Muskelvävnad i Fischer 344 råttor efter applicerade elektriska pulser av olikafältstyrka och pulslängd,Metoder: 99mTc-DTPA (totalt 150 MBq) administrerades intramuskulärt (i.m.) vid axelnsom en bolus i flera fraktioner om 50 l var och en i intervaller på 1 minut. Bil

This research uses data from observations of 8277 motorcyclists at various types of roads of the road hierarchy in Malaysia in 2015, to investigate the effects of road characteristics, motorcyclists’ riding behaviour, motorcyclists’ and motorcycles’ characteristics on the occurrence of riding with excessive speed. For data collection and analysis, new software, i.e. MECHROM, was developed. The spe

BACKGROUND: The Eight-Twenty-One (ETO) nuclear co-repressor gene belongs to the ETO homologue family also containing Myeloid Translocation Gene on chromosome 16 (MTG16) and myeloid translocation Gene-Related protein 1 (MTGR1). By chromosomal translocations ETO and MTG16 become parts of fusion proteins characteristic of morphological variants of acute myeloid leukemia. Normal functions of ETO homol

Den yttersta barriären mellan luften och blodomloppet i våra lungor består av en lipid-protein film. Denna lipid-protein blandning kallas för lungsurfaktant. Filmen bestående av lungsurfaktant stabiliserar alveolerna i våra lungor och gör att vi kan andas utan motstånd. Brist av lungsurfaktant kan orsaka svåra sjukdomar, till exempel hos förtidigt födda barn som ännu inte hunnit bilda tillräckligtThis thesis explores lipid self-assembly and aims to give a broad picture of self-assembly structures in simple and complex lipid-protein systems. The systems studied are lung surfactant, stratum corneum and simple model membranes. The lung surfactant mixture lines the alveolus in our lungs and stabilises the air- tissue interface. The lung surfactant lipid phase behaviour was here investigated wi

We present and compare the existing methods of heteroepitaxy of III-Vs on silicon and their trends. We focus on the epitaxial lateral overgrowth (ELOG) method as a means of achieving good quality III-Vs on silicon. Initially conducted primarily by near-equilibrium epitaxial methods such as liquid phase epitaxy and hydride vapour phase epitaxy, nowadays ELOG is being carried out even by non-equilib

Ett ökande omsorgsgivande från förföräldrar till barnbarn är en signifikant utveckling i Sverige (Bordone et al, 2023; Cantillon et al., 2021) en annan utveckling är att allt fler äldre har bonusbarnbarn, till följd av att de eller deras barn lever i ombildade familjer (Bildtgård & Öberg, 2017). Det intensiva förföräldraskapet utmärks av att bio-förföräldrar idag gör, och förväntas göra, mer o

The production team behind the television series Holocaust had a challenging task to find a character who the audience could relate to and try to understand, despite the knowledge that he was deeply involved in the mass executions on the Eastern front. In my paper, I analyse the fictional SS member Erik Dorf (Michael Moriarty). Dorf was based on several people, including the SS officer Otto OhlenThe production team behind the television series Holocaust had a challenging task to find a character who the audience could relate to and try to understand, despite the knowledge that he was deeply involved in the mass executions on the Eastern front. In my paper, I analyse the fictional SS member Erik Dorf (Michael Moriarty). Dorf was based on several people, including the SS officer Otto Ohlen

By the Merovingian Period (6–8th century CE) a large variety of dogs and the earliest evidence of dog leashes appear in South Scandinavia. This indicates exchange, breeding and use of new types of dogs in this period. The purpose of this study is to examine the social significance and function of dogs in the Merovingian Period in South Scandinavia based on an analysis of the Nabbero ̈r boat grave By the Merovingian Period (6–8th century CE) a large variety of dogs and the earliest evidence of dog leashes appear in South Scandinavia. This indicates exchange, breeding and use of new types of dogs in this period. The purpose of this study is to examine the social significance and function of dogs in the Merovingian Period in South Scandinavia based on an analysis of the Nabberör boat grave on

Background: Less than 500 participants have been included in randomized trials comparing hypothermia with regular care for out-of-hospital cardiac arrest patients, and many of these trials were small and at a high risk of bias. Consequently, the accrued data on this potentially beneficial intervention resembles that of a drug following small phase II trials. A large confirmatory trial is therefore

Indoor temperatures in apartment blocks are often indirectly controlled by the outdoor temperature using a feedforward control loop, in which the radiator supply temperature is a function of the outdoor tem- perature. However, this control principle cannot take into account heat gains or losses caused by tenants, electrical appliances, the sun, air leakage, etc., which may result in uneven indoor Indoor temperatures in apartment blocks are often indirectly controlled by the outdoor temperature using a feedforward control loop, in which the radiator supply temperature is a function of the outdoor temperature. However, this control principle cannot take into account heat gains or losses caused by tenants, electrical appliances, the sun, air leakage, etc., which may result in uneven indoor te

This study explores the importance of the means of ensuring watersupply in the formation of the architectural profile and basic socialorganization of Pompeii. It sees the city’s domestic water supply, forover two centuries ensured through rainwater-harvesting areas, basinsand cisterns situated mainly in and below the many atria, as a stabilizingfactor of both cityscape and household. Through the iThis study explores the importance of the means of ensuring watersupply in the formation of the architectural profile and basic socialorganization of Pompeii. It sees the city’s domestic water supply, forover two centuries ensured through rainwater-harvesting areas, ba-sins and cisterns situated mainly in and below the many atria, as a sta-bilizing factor of both cityscape and household. Through t

Measurements of fetal aortic blood flow velocity and fetal growth were performed in 178 pregnancies. In 87 cases, the estimated fetal weight was > 2 SD below the gestational age-related mean of the population. Three fetuses died in utero. In 148 children (84%) an assessment of overall intellectual ability was performed at 6.5 years of age. Verbal and global IQ was lower in the group with an abnorm

Measurements of fetal aortic blood flow velocity and fetal growth were performed in 178 pregnancies. In 87 cases, the estimated fetal weight was > or = 2 SD below the gestational age-related mean of the population. Three fetuses died in utero. In 149 children (85%), a neurological examination was performed at 7 years of age with special emphasis on minor neurological dysfunction. The frequency of