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Neurogenesis in the subventricular zone (SVZ), which gives rise to new neurons in the olfactory bulb, continues throughout life but declines with increasing age. Little is known about how aging affects the intrinsic properties of the neural stem and progenitor cells (NSCs) in SVZ and the functional characteristics of their neuronal progeny. Here, we have compared the properties of NSCs isolated fr
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Background. Tissue transglutaminase (tTG) autoantibodies are serological markers for celiac disease. The aim was to study the efficacy of the pTnT-rhtTG plasmid and subsequent diagnostic accuracy of tTG autoantibodies for childhood celiac disease using radioligand binding assays. Methods. Coupled in vitro transcription and translation of tTG were performed by pTnT-rhtTG as well as by the pGEMt Eas
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Objective: To evaluate the precision of the predictive cost-effectiveness assessment based on a phase 3 clinical trial with infliximab for the treatment of rheumatoid arthritis in Swedish clinical practice. Methods: Three patient cohorts were identified: the patients included in the infliximab trial (ATTRACT), patients initially treated with infliximab from a Swedish registry (STURE), a subset of
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The Sustainable Development Goals (SDGs) with their 169 targets and 231 indicators epitomise the trend of global governance by numbers. This article suggests the notion of a global “indicator reporting trajectory” that is shaped by three main elements: the politics of indicators, a reporting infrastructure and indicator advocacy. I propose that indicator reporting trajectories may result either in
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In 1524, Petrus Apianus published two closely related works—one the Latin Cosmographicus liber, aimed at an educated audience of international readers, and the other, Ein kunstlich Instrument, a shorter, more practical book for those who could read German but had no Latin. Both books nevertheless make use of most of the same instruments, including Apianus’ early volvelles. Most of these instrument