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Crosstalk between colorectal cancer cells and tumour-associated macrophages

Popular Abstract in English Colorectal cancer (CRC) is a cancer caused by uncontrolled cell growth in colon or rectum. CRC is the third most common cancer and the fourth leading cause of cancer related death in the world. It is a multifactorial disease, both genetic predisposition and environmental play a role in the development of CRC. CRC is closely linked to chronic inflammation. Patients with Colorectal cancer (CRC) is the third most common cancer and the fourth leading cause of death from cancer worldwide. People suffering from inflammatory bowel disease, such as Crohns’ disease and ulcerative colitis, are at an increased risk of developing CRC. The development of CRC is highly influenced by the tumour microenvironment. Tumour cells are able to recruit macrophages and change their beh

Oxidation of Ketones: A (Chemo-) Enzymatic Approach Using Oxygenases and Hydrolases

Popular Abstract in English The thesis that you are reading at this moment was printed using climate compensated paper, a sign that consciously or not you are contributing somehow to control the current environmental issues in our planet. It would not be nice if every single article used in your daily life contains information about how environmentally friendly that product is? We have to think “bOxidation reactions are important in organic chemistry as well as in nature. In industry, oxidations are commonly used for the synthesis of chemicals and pharmaceuticals, however such processes have a number of limitations, they use chlorinated solvents, stoichiometric oxidation reagents, and in some cases the reagents that have risks of explosion during transportation and storage. This has called

Costs and Tactics in the Evolution of Reproductive Effort

Popular Abstract in Swedish Denna studie fokuserar på reproduktionskostnader och de energetiska taktiker som en reproducerande individ kan utnyttja för att tillfredsställa det ökade behovet av energi och näring under reproduktionen. Reproduktionskostnader har traditionellt definierats som reduktioner av den framtida potentiella produktionen av avkomma, orsakade av en nuvarande reproduktiv investerThis study focuses on various aspects of costs of reproduction and the evolution of energetic breeding tactics. It emphasizes the distinction between demographic costs of reproduction expressed already before current offspring have reached independence (prebreeding costs), and costs expressed only after offspring independence (postbreeding costs). Prebreeding costs have only rarely been appreciate

Towards More Coherent and Sustainable Biomass Policy: Examining European biomass-to-energy planning

Coordination of policies embracing biomass use has been called for in order to speed up progress towards the European Union renewable energy and climate change goals. Policy coordination and coherence is also required if the many complex and diverse issues constraining sustainable bioenergy development are to be addressed. To contribute to meeting such needs this doctoral thesis provides insights

Att flytta till särskilt boende. : Äldres upplevelser av transition, timing och relationer.

Över 80 000 personer bor på särskilt boende i Sverige. Flytten dit är ofta livets sista och kan medföra psykisk och fysisk påfrestning med risk för depression, försämrad hälsa och för tidig död. Endast personer med omfattande hjälpbehov beviljas plats, och enligt lag får flytten inte ske mot den äldres vilja. Trots ökad skörhet förväntas individen alltså själv ta stort ansvar för flyttprocessen. DMore than 80,000 people live in nursing homes in Sweden. The move isoften the final relocation in life and may involve both psychological andphysical strain, with risks of depression, deteriorating health, and prematuredeath. Only individuals with extensive care needs are granted placement,and by law, the move cannot be made against the will of the older person.Despite increased frailty, individua

Proletariatets polyfoni - – Västerländsk harmonik i kinesisk musik under 1900-talets första hälft

Title: Proletarian polyphony - Western harmony in Chinese music from the first half of the 20th century The aim of this essay is to examine the use of harmony and polyphony in Chinese music from the first half of the 20th century. Traditional Chinese music contains no chords and no polyphony. At the turn of the 20th century China showed an increasing interest in European culture and music. Many C

Service Life Assessment of Harbor Structures - Case studies of chloride ingress into concrete and sheet piling corrosion rates

Popular Abstract in English The two most used building materials in harbor structures are undoubtedly steel and concrete. These two materials are often combined in the structures of wharfs and quays where most steel sheet pile walls have cap beams of reinforced concrete. The degradation processes of these structures must be taken into account both when designing new structures and when inspecting The two most used building materials in harbor structures are undoubtedly steel and concrete. These two materials are often combined in the structures of wharfs and quays where the steel sheet pile walls often have cap beams of reinforced concrete. The degradation processes of these structures must be taken into account both when designing new structures and when inspecting existing harbor structu

Etik och känslor : en empirisk studie av skuld- och medkänslor hos gymnasieelever – en prövning av Ortonys teori

Popular Abstract in SwedishEn del av Ortonys teorimodell angående den kognitiva strukturen hos emotioner testades på svenska gymnasieelever. Den del av teorin som användes i föreliggande studie handlade om de emotioner som tillskrivs den som utfört s.k. orätta handlingar. De eventuella känslor som man får när man utfört en orätt handling kallar Ortony för "self reproach" emotioner. Detta begrepp sThe purpose of this study was to test parts of Ortony's theoretical model relating to the cognitive structure of emotions in Swedish upper secondary school students. That part of the model, which was appropriate for the present study, deals with emotions attributed to the person who has perpetrated what is referred to as blameworthy actions. Ortony calls the possible emotions that you experience w

Depressive Personality Disorder : Construct, measurement, clinical correlates, and treatment outcome

Popular Abstract in Swedish Depression är ett allvarligt och potentiellt förödande hälsoproblem som drabbar flera miljontals människor i världen. Trots framsteg inom depressionsforskningen återstår flera frågor kring varför vissa individer upplever depression, och andra inte, och varför vissa blir hjälpta av behandling, och andra inte. Den forskning som rapporteras här tar som utgångspunkt hypotesDepression is a serious and potentially devastating health problem, impacting millions of individuals worldwide. Although advances have been made in depression research, there remain a number of outstanding questions as to why certain individuals experience depression and why some respond to treatment and others do not. The present research takes a starting-point in the hypothesis that the existen

Studies of molecular mechanisms of telomere maintenance in Naumovozyma castellii

POPULAR SCIENTIFIC SUMMARYI was on my way home, sitting on the bus. My tired eyes swept through the pages of the local newspaper and that was the moment I met Lisa. She had previously been diagnosed with cancer. She had recovered and was back to her daily life. Unfortunately the cancer has come back and it has spread to several organs. Lisa as a mother of two kids, as a wife, as a daughter, as a sTelomeres are special DNA-protein structures that protect ends of chromosomes from being recognized as double-strand breaks. Telomeres consist of tandemly repeated units of TG-rich DNA and associate with telomere-specific proteins.When a cell replicates its chromosomes, a certain piece of DNA is lost from chromosomal ends due to the ´´ end replication problem´´. This progressive shortening of telo

Helical tomotherapy for total marrow and total skin irradiation : Optimisation, verification, and clinical results

In modern cancer therapy, radiotherapy (RT) is a vital part of most treatments. Most RT treatments in Sweden are performed using intensity-modulated radiotherapy (IMRT) with fixed or dynamic arc delivery. The dose gradients outside the target are steep, the margins are small, and the treatment delivery is complicated. Complicated treatments increase the requirement for control of the uncertainties

Hur digital vård kan påverka vårdpersonalens arbete och relation till patienterna – En studie av införandet av en digital applikation

Bakgrund Framväxten av hälsoapplikationer som gör det möjligt för patienter att kontakta och kommunicera med vårdpersonal digitalt kan förändra hur patienter ser på sin vård och hur de kontaktar vårdpersonalen (WHO, 2011). Digitala system kan också, utifrån sin design, ge förutsättningar för relationscentrerad vård genom att patienterna ges möjlighet att, i samverkan med vårdpersonalen, vara aktiv

Hemtjänstpersonalens arbetsmiljö och hälsa i fyra skånska kommuner

I denna rapport presentas resultaten från en arbetsmiljöenkät som genomförts ihemtjänsten i fyra skånska kommuner (2 landsortskommuner, 1 medelstor stad, 1 storstad). Enkäten syftade till att brett kartlägga hemtjänstpersonalens arbetsmiljö, hälsa och välmående och är en del av det fyraåriga forskningsprojektet ”Att skapa en bättre arbetsmiljö i hemtjänsten - participativt förändringsarbete i prak

ROTEM and vitro reversal of warfarin with APCC

Background: Warfarin-treated patients with a prolonged Prothrombin Time (PT) can have a normal rotational thromboelastometry (ROTEM) clotting time (CT). A previous in vitro study found that activated prothrombin complex concentrates (APCC) could reverse an albumin-induced coagulopathy monitored with ROTEM, but that prothrombin complex concentrates (PCC) could not. The aim of this study was to inveBackground: Warfarin-treated patients with a prolonged Prothrombin Time (PT) can have a normal rotational thromboelastometry (ROTEM) clotting time (CT). A previous in vitro study found that activated prothrombin complex concentrates (APCC) could reverse an albumin-induced coagulopathy monitored with ROTEM, but that prothrombin complex concentrates (PCC) could not. The aim of this study was to inve

Coupled luminescence and cosmogenic nuclide dating of postglacial deflation surfaces and sand drift on a raised ice-contact delta at Veinge, SW Sweden

Wind-abraded cobbles (ventifacts) and aeolian sand are known from the sandy-gravelly coastal areas of south-western Sweden, especially in association with raised deltas. Ventifacts are recorded on at least two different stratigraphic levels, at some sites atop glaciofluvial sediment, at other sites atop littoral deposits, and in some places at both levels, while aeolian sand usually forms a surficWind-abraded cobbles (ventifacts) and aeolian sand are known from the sandy-gravelly coastal areas of south-western Sweden, especially in association with raised deltas. Ventifacts are recorded on at least two different stratigraphic levels, at some sites atop glaciofluvial sediment, at other sites atop littoral deposits, and in some places at both levels, while aeolian sand usually forms a surfic

Growing up : Early-life circumstances and wellbeing throughout life, Sweden 1905–2016

The first years of life are a critical period of development, and circumstances during this period can affect individuals throughout life. But to what extent do disadvantaged circumstances in childhood affect individual wellbeing in later life and for whom? Can interventions in childhood break adversity over the life course? For whom are interventions most effective and why? This thesis aims to in

Förändrade förutsättningar för samverkan : Idéburna erfarenheter av idéburen offentlig samverkan med utgångspunkt i NAD

Rapporten presenterar resultaten av en studie som vi genomfört på uppdrag av Nätverket Idéburen Sektor Skåne och handlar om idéburna erfarenheter av samverkan med offentliga organisationer inom NAD. Syftet är att förstå hur strukturella förändringar och organisatoriska strategier har påverkat samverkan över tid. Tidsperioden sträcker sig från 2016 då vi genomförde en utvärdering av samverkan och 2

X-ray microtomography and 3D visualization of a plesiosaur propodial (Reptilia: Sauropterygia) from the Late Cretaceous of southern Sweden provides insights in bone histology, bone microstructures, and bone growth.

Polycotylid and elasmosaurid plesiosaurs inhabited the Kristianstad Basin during Late Cretaceous (uppermost lower Campanian Belemnellocamax mammillatuszone) around 80 million years ago. The setting represents one of the most famous Mesozoic fossil sites in Scandinavia. The Kristianstad Basin fossils are generally fragmentary and isolated due to high-energy environments in a protected shallow innerPolycotylid and elasmosaurid plesiosaurs inhabited the Kristianstad Basin during Late Cretaceous (uppermost lower Campanian Belemnellocamax mammillatuszone) around 80 million years ago. The setting represents one of the most famous Mesozoic fossil sites in Scandinavia. The Kristianstad Basin fossils are generally fragmentary and isolated due to high-energy environments in a protected shallow inner

Disease Prevention and State-building in China: The Rise and Fall of China's Barefoot Doctor System(1968-1985)

Barefoot doctor system is an important part of primary health care policy changes in China after the founding of New China, is a special viewpoint to study the special period of grassroots political change. Why medical care’s come into the sight of top leaders at that time? What does medical care system mean to modern state building? There may be a certain natural link between the body and the nat

Geochemical and palaeomagnetic characteristics of a Swedish Holocene sediment sequence from Lake Storsjön, Jämtland

Som en del i ett fransk-svensk sammarbete i syfte att rekonstruera holocena klimatförändringar i centrala och norra Europa, togs en sedimentsekvens upp från Storsjön, Jämtland och analyserades för geokemiska och paleomagnetiska egenskaper. Den provtagna delen av sekvensen, bestående av en fryskärna samt tre Niederreiter-kärnor, tydliggjorde förändringar orsakade av klimat samt antropogen påverkan As a part of a French-Swedish collaboration project to reconstruct middle to northern European climate variations during the Holocene, a sediment sequence from Lake Storsjön, Jämtland was retrieved and analysed for geochemical and palaeomagnetic properties. The subsampled sequence, composed of one freeze core and three Niederreiter piston cores, revealed information of both climatic, environmental