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Research and Development (R&D) in the pharmaceutical sector traditionally occurred in closed, siloed institutional settings. This approach was a function of a rights-oriented model which framed access and reuse of data (data sharing) as a threat to rights-holders. However, a closed model of explorative collaboration is less suited to today’s more complex scientific ecosystem, where external en

Sammanfattande kommentarer och rekommendation • Opioider och bensodiazepiner är kraftfulla läkemedel med god patientnytta i utvalda fall och under begränsade behandlingstider.• Läkare/vårdenhet som initierat förskrivning har ansvar för denna tills den upphört eller tills annaninstans accepterat övertag – Behandlingsansvar• Basbehandling – överväg alltid först alternativa behandlingsstrategier, såv

Local political leaders as well as international organizations have embraced participatory budgeting in response to problems of political exclusion and citizens’ dissatisfaction with representative democracy. This article provides a framework to highlight important aspects of the politics of participation. The framework allows scholars to explore how factors external to spaces of participation intLocal political leaders as well as international organizations have embraced participatory budgeting in response to problems of political exclusion and citizens’ dissatisfaction with representative democracy. This article provides a framework to highlight important aspects of the politics of participation. The framework allows scholars to explore how factors external to spaces of participation int

This chapter delves into the challenges encountered by victims of human trafficking and other forms of labour exploitation in Sweden as they struggle to access social rights and justice. By drawing from theories of victimisation as an interactional process, the study examines the role of professionals such as government agents, social services, unions, and NGOs as facilitators in assisting victimsThis chapter delves into the challenges encountered by victims of human trafficking and other forms of labour exploitation in Sweden as they struggle to access social rights and justice. By drawing from theories of victimisation as an interactional process, the study examines the role of professionals such as government agents, social services, unions, and NGOs as facilitators in assisting victims

Artificial neural networks is one of the most commonly used machine learning algorithms in medical applications. However, they are still not used in practice in the clinics partly due to their lack of explanatory capacity. We compare two case-based explanation methods to two trained physicians on analysis of electrocardiogram (ECG) data from patients with a suspected acute coronary syndrome (ACS).

Little is known about pediatric surgical disease in resource-poor countries. This study documents the surgical care of children in central Haiti and demonstrates the influence of the 2010 earthquake on pediatric surgical delivery. METHODS: We conducted a retrospective review of operations performed at Partners in Health/Zanmi Lasante hospitals in central Haiti. RESULTS: Of 2,057 operations perfor

This paper draws on two experiences of undertaking comparative research in England,Sweden and Italy, and offers a discussion of the kinds of dilemmas raised in relation tolanguage and meaning surfaced by these. Its primary focus is to examine the reflexiveconstruction of meaning, both in relation generally to the workings of an internationalresearch team and, more specifically, how such constructiThis paper draws on two experiences of undertaking comparative research in England, Sweden and Italy, and offers a discussion of the kinds of dilemmas raised in relation to language and meaning surfaced by these. Its primary focus is to examine the reflexive construction of meaning, both in relation generally to the workings of an international research team and, more specifically, how such constr

The large-scale mass mobilizations and colossal demonstrations of the last decade have shown that digital and social media platforms, globally, now play significant roles in early formation and further facilitation of activist movements, interested in progressive causes and societal changes. However, the repercussions of the very same events have also clearly shown the shortcomings of mediatized a

In response to escalating disasters, inclusive crisis planning is crucial. This study examines a specialized workshop that engaged people with disabilities in crisis planning, focusing on a simulated flood scenario. Stakeholders from disability organizations and the local municipality collaborated, including eight crisis communicators and thirteen individuals with disabilities. The workshop facili

High-speed communication using the copper network, originally installed for telephony, is one of the dominant Internet access techniques. Several variants of a technology referred to as digital subscriber line (DSL) have been developed, standardized and installed during the last two decades. Essentially, DSL achieves high rates by exploiting wide bands of the copper cable channel. The shorter the

Several psychiatric disorders may be characterized by peripheral telomere shortening. However, it is unclear whether telomere shortening is associated with these psychiatric disorders per se or, rather, with underlying dimensional parameters that are often, but not necessarily, associated with them. We explored the association between dimensional psychopathological measures and telomere length (TL

Some leading science programs undertaken with Very Large Telescopes and challenges driving the progress of the Extremely Large Telescopes are discussed together with the corresponding requirements. They concern expolanets, Earth-like planets, habitable zones, formation of stars and galaxies, first stars and cosmology. A description is attempted

Imprinting theory suggests that founding conditions are stamped' on organizations, and these imprinted routines often resist change. In contrast, strategic choice theory suggests that the firm can overcome organizational inertia and deliberately choose its future. Both theories offer dramatically different explanations behind an organization's capacity for change. IPO firms provide a unique contex

Cyperus fuscus was thought to be extinct in Sweden until it was rediscovered at Lake Vombsjön, Skåne, after 63 years in 2013. The species also occurred at the lake 2014—2021, but in very variable numbers. The variation depended largely on the water level during late summer. Favourable conditions in form of low levels in late summer have also occurred prior to 2013, though less frequently than in rCyperus fuscus was rediscovered at Lake Vombsjön in Skåne, southernmost Sweden, in 2013. The species occurred there between 1945 and 1950, which was the latest Swedish record except for a casual occurrence in a plant nursery. The comeback was spectacular with 2770 individuals counted along 4.7 km of the shore. In 2013, the water level was exceptionally low for technical reasons, with up to 100 m o

Using Low Energy Electron Diffraction (LEED) and Scanning Tunneling Microscopy (STM) we have investigated the structure of the GaP(111)B surface. We have previously studied the formation of Ga droplets on GaP(111)B above the maximum temperature for congruent evaporation. In the present work, we investigate the nanometer-sized pyramid-shaped crystallites that are found on the GaP(111)B surface and

A genetic algorithm for optimal placement of optical fibers in arbitrary geometries for interstitial photodynamic therapy has been developed. Based on calculated fiber positions, the diffuse light distribution is simulated by solving the diffusion equation by means of the finite element method and the treatment time is calculated. Utilizing an instrument for interstitial photodynamic therapy that

One part of the objective is to analyze how different ventilation systems perform in practice when it comes to supplying and exhausting designed air flow in different outdoor and indoor conditions. The other part is to analyze the design criterias and the energy use of a variable air volume system based on controlled static pressure at the branch duct level and supplying outdoor air only. To inves