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Developing an open innovation culture in Lund’s innovation district

Recent years have brought new directionality to university’s work with innovation – increasing the focus on addressing societal challenges and contributing to much broader frames for impact. Working with complex challenges, where no one actor can do everything by themselves, requires collaboration across actor groups (private sector, academia, public sector, civil society), industrial sectors, dis

By Torches, Bones, and Temples : Material Metonyms in Personal Oaths in Latin Literature

Oath-taking during Roman Antiquity constitutes a telling example of how words and matter interplay and relate to one another. Ancient Latin literature provides a myriad of representations of oaths sworn, both fictive and supposedly historical, where matter somehow figure in the procedure. In this study, a selection of personal oaths from Roman literature are explored in terms of materiality and ag

Continuous quality assurance and ML pipelines under the AI Act

More than ever, Machine Learning (ML) as a subfield of Artificial Intelligence (AI) is on the rise and is finding its way into safety-critical software applications. However, when it comes to quality assurance (QA) and trustworthiness, integrating ML models into software comes with challenges that may not be apparent at first glance. The European Union (EU) aims to tackle this problem with new reg

Prescription of pain medication among older cancer patients with and without an intellectual disability : A national register study

Background: The longevity for people with intellectual disability (ID) has significantly increased in developed countries during the past decades. Consequently, the incidence of cancer is expected to increase in this group. The aim of the present study was to investigate the prescription of pain medication in older cancer patients with intellectual disability (ID) compared to older patients in the

General practitioners' preferences for future continuous professional development : evidence from a Danish discrete choice experiment

BACKGROUND AND OBJECTIVES: Danish general practitioners (GPs) follow a voluntary continuous professional development (CPD) programme based on accredited activities. Inspired by a current interest in CPD, this study investigates GPs' preferences for future CPD programmes.METHODS: The preferences were tested in a Discrete Choice Experiment (DCE) sent to 1079 randomly chosen GPs. The GPs were asked t

QREME – Quality requirements management model for supporting decision-making

[Context and motivation] Quality requirements (QRs) are inherently difficult to manage as they are often subjective, context-dependent and hard to fully grasp by various stakeholders. Furthermore, there are many sources that can provide input on important QRs and suitable levels. Responding timely to customer needs and realizing them in product portfolio and product scope decisions remain the main

Stress and circulating cell-free mitochondrial DNA : A systematic review of human studies, physiological considerations, and technical recommendations

Cell-free mitochondrial DNA (cf-mtDNA) is a marker of inflammatory disease and a predictor of mortality, but little is known about cf-mtDNA in relation to psychobiology. A systematic review of the literature reveals that blood cf-mtDNA varies in response to common real-world stressors including psychopathology, acute psychological stress, and exercise. Moreover, cf-mtDNA is inducible within minute

Complete blood counts with red blood cell determinants associate with reduced beta-cell function in seroconverted Swedish TEDDY children

Objectives: To investigate whether changes in complete blood count (CBC) in islet autoantibody positive children with increased genetic risk for type 1 diabetes are associated with oral glucose tolerance tests (OGTT) and HbA1c over time. Methods: The Environmental Determinants of Diabetes in the Young (TEDDY) study follows children with increased risk for type 1 diabetes in the United States, Germ

Radiofrequency bias correction of magnetization prepared rapid gradient echo MRI at 7.0 Tesla using an external reference in a sequential protocol

At field strengths of 7 T and above, T1-weighted imaging of human brain suffers increasingly from radiofrequency (RF) B1 inhomogeneities. The well-known MP2RAGE (magnetization prepared two rapid acquisition gradient echoes) sequence provides a solution but may not be readily available for all MR systems. Here, we describe the implementation and evaluation of a sequential protocol to obtain normali

The convivial and the pastoral in patient–doctor relationships : a multi-country study of patient stories of care, choice and medical authority in cancer diagnostic processes

Experiences of cancer diagnosis are changing in light of both the increasingly technological-clinical diagnostic processes and the socio-political context in which interpersonal relations take place. This has raised questions about how we might understand patient–doctor relationship marked by asymmetries of knowledge and social capital, but that emphasise patients’ empowered choices and individual

Accelerating research on biological aging and mental health : Current challenges and future directions

Aging is associated with complex biological changes that can be accelerated, slowed, or even temporarily reversed by biological and non-biological factors. This article focuses on the link between biological aging, psychological stressors, and mental illness. Rather than comprehensively reviewing this rapidly expanding field, we highlight challenges in this area of research and propose potential s

Photorefractive and Spectroscopic Properties of Pr:LiNbO3

From the ultraviolet induced absorption, we have found a broad blue band and little involvement of Pr ions in ultraviolet illumination. Ultraviolet excited photoluminescence and the excitation spectra for visible emission were also measured in Pr:LiNbO3. We estimated photovoltaic constant and photoconductivity by measuring photovoltaic current and voltage with different boundary conditions. With u

Serum tau fragments as predictors of death or poor neurological outcome after out-of-hospital cardiac arrest

Background: Anoxic brain injury is the primary cause of death after resuscitation from out-of-hospital cardiac arrest (OHCA) and prognostication is challenging. The aim of this study was to evaluate the potential of two fragments of tau as serum biomarkers for neurological outcome. Methods: Single-center sub-study of 171 patients included in the Target Temperature Management (TTM) Trial randomly a

Hypothermia versus normothermia after out-of-hospital cardiac arrest; the effect on post-intervention serum concentrations of sedatives and analgesics and time to awakening

Background: This study investigated the association of two levels of targeted temperature management (TTM) after out-of-hospital cardiac arrest (OHCA) with administered doses of sedative and analgesic drugs, serum concentrations, and the effect on time to awakening. Methods: This substudy of the TTM2-trial was conducted at three centers in Sweden, with patients randomized to either hypothermia or