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PBMC telomerase activity, but not leukocyte telomere length, correlates with hippocampal volume in major depression.

Accelerated cell aging, indexed in peripheral leukocytes by telomere shortness and in peripheral blood mononuclear cells (PBMCs) by telomerase activity, has been reported in several studies of major depressive disorder (MDD). However, the relevance of these peripheral measures for brain indices that are presumably more directly related to MDD pathophysiology is unknown. In this study, we explored

Validation of brief cognitive tests in mild cognitive impairment, Alzheimer's disease and dementia with Lewy bodies.

Popular Abstract in Swedish Bakgrund Uppskattningsvis har 34 miljoner människor världen över någon typ av demenssjukdom. Sjukdomarna leder till stort lidande för både patienter och anhöriga och beräknas kosta samhället 422 miljarder amerikanska dollar årligen. Den vanligaste demenssjukdomen är Alzheimers sjukdom och den utgör ca 60–70% av alla demenssjukdomar. Sjukdomarna blir allt vanligare och åBackground It is estimated that 34 million people suffer from dementia, costing society US$422 billion each year. Alzheimer’s disease (AD) is the most common dementia and the global prevalence is predicted to increase to over 100 million people by the year 2050, with the greatest increase in developing countries. Therefore, inexpensive and efficient instruments are required for investigation and e

One Step Forward and One Step Back. State regulation of environment and sustainable development through the use of the Education Act, school curricula and syllabuses (1990-2010)

The aim of this sociology of law-orientated article is to analyse and describe legislative and regulatory processes concerning the task given to schools focusing on environment and sustainable development. We are describing the policy-making processes in this field from 1990 to 2011. The study involves key interviews and content analysis of national policy documents as well as legal sources, in or

Why the mirror is a sign — and why the television picture is no mirror. Two episodes in the critique of the iconicity critique

In his recent work, Eco abandons his conventionalist theory of pictures, which was heavily censored by, among others, the present author. In so doing, however, Eco now goes to the other extreme, claiming that television images are like mirrors, which are no signs. It is my contention that Eco fails to come up with a more acceptable theory of iconicity. Since Eco is one of the few semioticians conc

Pollen analysis, chronology and palaeomagnetism of three Late Weichselian sites in southern Sweden

Popular Abstract in Swedish Pollenanalys, kronologi och paleomagnetism på tre senglaciala lokaler i södra Sverige Senglaciala sjösediment (d.v.s. avsatta under slutet av den senaste istiden) från tre bassänger i södra Sverige, Torreberga i Skåne, Farslycke i Blekinge och Bolmen i Småland, har studerats med avseende på pollensammansättning och paleomagnetism. Åldersbestämning och tidsjämförelser bThree sites, Torreberga in Skåne, Farslycke in Blekinge and Lake Bolmen in Småland, with Late Weichselian lake sediments were studied with respect to pollen analysis and palaeomagnetism. The chronologies are based on pollen stratigraphical correlations, radiocarbon dating and, for two of the sites, on a clay-varve chronology. The stratigraphies were correlated to the GRIP event stratigraphy and th

Reflection/Transmission Study of Two Fabrics with Microwave Properties

In this study, the transmission and reflection of two conductive fabrics are investigated in the frequency range from 2 to 18 GHz. One of the fabrics is a non-woven polypyrrole and the other consists of a polyethylene warp with steel threads in the weft. Reflection and transmission measurements are performed in order to characterize the electromagnetic properties of the materials. Reflection measu

The serpin PN1 is a feedback regulator of FGF signaling in germ layer and primary axis formation.

Germ layer formation and primary axis development rely on Fibroblast growth factors (FGFs). In Xenopus, the secreted serine protease HtrA1 induces mesoderm and posterior trunk/tail structures by facilitating the spread of FGF signals. Here, we show that the serpin Protease nexin-1 (PN1) is transcriptionally activated by FGF signals, suppresses mesoderm and promotes head development in mRNA-injecte

SimSWE – a library of reusable components for software process simulation

SimSWE is a library of components for modeling and simulation of software engineering processes. It consists of a generic, implementation independent description of the components and a reference implementation using the MATLAB® / Simulink® environment. By providing ready-to-use building blocks for typical functionality, the library should facilitate and ease the use of simulation to analyze softw

Human resources and access to maternal health care

The lack of human resources is one of the main bottlenecks to achieving the Millennium Development Goals on maternal and child health. A coherent national policy, recognized across government, needs to be in place to overcome this especially in countries severely affected by HIV/AIDS. Such a policy should cover selection of pre-service students, the qualifications of trainers and training sites, s

Identification of cystatin C as a new marker of glomerular filtration rate, and of shrunken pore syndrome – a new kidney disorder defining selective glomerular hypofiltration syndromes – calls for expansion of the international KDIGO guidelines

Cystatin C was identified as a marker of glomerular filtration rate (GFR) in 1979, and the parallel analysis of cystatin C and creatinine led to the identification of shrunken pore syndrome (SPS) ? a new kidney disorder ? in 2015. Since then, it has been shown that cystatin C in many aspects is superior to creatinine as a marker of GFR and cardiovascular risk. SPS, an entity within the selective g

Linjeutvidgning- En studie av linjeutvidgning inom konfektyrbranschen på den svenska marknaden

Syftet med uppsatsen är att ur ett företagsperspektiv undersöka hur en linjeutvidgning påverkar varumärket samt vilka faktorer som gör att en linjeutvidgning lyckas. Vi har använt oss av en kvalitativ metod med semistrukturerade intervjuer. Intervjuer har genomförts med marknadsdirektören för Cloetta Fazer, Sverige, en marknadschef på Leaf Sverige, en marknadschef på Kraft Foods samt med en ekonom

Socioekonomisk utveckling och demokrati - en förlegad teori?

Forskningen om teorin gällande sambandsförhållandet socioekonomisk utveckling och demokrati, även kallad moderniseringsteorin, har pågått sedan slutet av 1950-talet och pågår än idag. Jag har gett mig in på att göra en egen studie av sambandsförhållandet för att försöka verifiera eller falsifiera teorin. Detta är ingen enkel uppgift då det är mycket svårt att bevisa att det är just variabeln X som

Att mäta och undersöka demokrati - med Region Skåne som empiriskt fall

Region Skåne skapades för tio år sedan med ändamålet att förstärka den regionala demokratin. Den här uppsatsen syftar till att studera hur pass långt Region Skåne kommit i den demokratiska utvecklingen. Utifrån en normativ analys diskuteras de tre demokratiidealen, valdemokrati, deltagardemokrati och samtalsdemokrati, som alla bör ingå för att kunna göra en demokratisk bedömning. De tre demokratii

The role of the print media in the fight against HIV/AIDS amongst the women in Cameroon: Case of the Cameroon Post newspaper

HIV/AIDS has been a serious challenge which has plagued the world at large especially Africa. This thesis; The role of the print media in the fight against HIV/AIDS amongst the women of Cameroon; Case of the Cameroon Post newspaper investigates the strategies and techniques that have been used by the Cameroon post newspaper in the fight against HIV/AIDS amongst the women in Cameroon. This work als

Rural Clusters: Promoting Structural Transformation in Armenia

The purpose of this thesis was to investigate the possibility of application of the cluster based rural development approach in Armenia to promote its structural transformation. Case study was selected as a research methodology, and both qualitative and quantitative methods were employed. Analysis of the key findings from the ‘field’, i.e. - the potential cluster, shows that rural households pract

Patient satisfaction after expenditure cutback and intervention to improve nursing care at a surgical clinic. At two-year follow-up.

Between 1991 and 1994 the number of beds in the surgical clinic at a central hospital in Southern Sweden was cut back by almost 50%. To develop the nursing care and to control the effects of the budgetary cuts, an intervention, including nursing care development, of an organization that would secure continuity in the nurse-patient relationship, individually planned care and quality assurance for a

Languages and Tools for Optimization of Large-Scale Systems

Popular Abstract in Swedish Modellering och simulering är etablerade tekniker för att lösa designproblem inom många olika ingenjörsdiscipliner idag. Dedicerade språk, såsom Modelica, och effektiva mjukvaror finns också tillgängliga. I denna avhandling presenteras en språklig utvidgning av Modelica, Optimica, som är avsedd för formulering av dynamiska optimeringsproblem. För att demonstrera användnModeling and simulation are established techniques for solving design problems in a wide range of engineering disciplines today. Dedicated computer languages, such as Modelica, and efficient software tools are available. In this thesis, an extension of Modelica, Optimica, targeted at dynamic optimization of Modelica models is proposed. In order to demonstrate the Optimica extension, supporting sof