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Cerebrospinal fluid biomarkers of white matter injury and astrogliosis are associated with the severity and surgical outcome of degenerative cervical spondylotic myelopathy

BACKGROUND CONTEXT: Degenerative cervical spondylotic myelopathy (DCM) is the commonest form of spinal cord injury in adults. However, a limited number of clinical reports have assessed the role of biomarkers in DCM. PURPOSE: We evaluated cerebrospinal fluid (CSF) biomarkers in patients scheduled for DCM surgery and hypothesized that CSF biomarkers levels (1) would reflect the severity of preopera

Distinct subcellular autophagy impairments in induced neurons from patients with Huntington's disease

Huntington's disease (HD) is a neurodegenerative disorder caused by CAG expansions in the huntingtin (HTT) gene. Modelling Huntington's disease is challenging, as rodent and cellular models poorly recapitulate the disease as seen in aging humans. To address this, we generated induced neurons (iNs) through direct reprogramming of human skin fibroblasts, which retain age-dependent epigenetic charact

Engagerad fixare eller ytterligare en person som ”bara pratar”? Mödrars röster om samordnare i ungdomsvården

Syftet med denna studie är att utifrån mitt empiriska material kartlägga och beskriva hur föräldrar till barn intagna på särskilda ungdomshemmen tolkar, definierar och upplever ett behandlingsprojekt, som involverade olika myndigheter, benämnt Motverka Våld och Gäng. Dessutom uppmärksammas hur de anställda samordnarna uppfattades och kategoriserades av föräldrarna. ”Föräldrar” blir i undersökninThe aim of this study is to analyze how mothers with children placed in Swedish juvenile homes interpret, define and perceive, on the one hand, the project “Motverka Våld och Gäng” meaning “Counteract Violence and Gangs”, and on the other hand the role of the Coordinators employed in this project. The mothers who were interviewed spoke about some Coordinators that they appreciated. They then pain

Human eeg responses to exact and statistical fractal patterns.

Attention Restoration Theory point to nature as a particularly good candidate for restoring the ability to focus and inhibit distractions. However, little effort has been directed to elaborating on what makes nature's visual pattern unique for restoration purposes. One suggested explanation is the fractal properties of natural patterns (Hagerhall, 2005). Both perception studies (Hagerhall et al.,

Copyright Protection of Software under the TRIPS Agreement - Software reengineering and reverse engineering in the context of international trade law

In 1994, the Agreement on Trade-Related Aspects of Intellectual Property Rights (TRIPS) was adopted as part of the Agreement Establishing the World Trade Organization (WTO). Pursuant to the TRIPS Agreement copyright protection of computer programs for the first time had received explicit recognition on the international level. Despite obligating all WTO Members to protect computer programs as lite

Auschwitz, autenticitet, kunskap

This essay reflects on issues surrounding the remembrance and teaching of the Holocaust. It was commissioned by the project Living History and the Swedish Prime Minister's Office.

Test Cost Modeling for 3D Stacked Chips with Through-Silicon Vias

In this paper we have proposed a test cost model for core-based 3D Stacked ICs (SICs) connected by Through Silicon Vias (TSVs). Unlike in the case of non-stacked chips, where the test flow is well defined by applying the same test schedule both at wafer sort and at package test, the most cost-efficient test flow for 3D TSV-SICs is yet undefined. Therefore, analysing the various alternatives of tes