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Sex-Specific Cardiovascular Consequences of Long-Term High-Salt Diet in Mice

BACKGROUND: Excessive dietary salt intake is associated with elevated blood pressure and damage to organs including the heart, vasculature, and kidneys. Women are more prone to salt-sensitive hypertension, yet preclinical studies often focus on men.METHODS: To examine sex-specific responses to chronic salt loading, male and female C57Bl6/J mice were fed a high-salt diet (HSD; 8% NaCl) from 7 to 14

Den samtida receptionen och värderingen av AI-genererad litteratur i Sverige

In this article, we analyze the reception of the AI-generated poetry collection Ammaseus horisont: AI tolkar Karin Boye (2020) and discuss the more general debate about AI-generated literature in the Swedish press since November 2022, when OpenAI made ChatGPT available to the public. Specifically, we analyze the ways in which Swedish critics construct the literary value of Ammaseus horisont and un

Comprehensive multifaceted analysis for unveiling the driving factors of groundwater decline

Groundwater, as a vital water resource in arid and semi-arid regions, plays a crucial role in sustaining human livelihoods, agriculture, and industry. Over recent decades, these areas have witnessed rapid groundwater depletion, raising concerns about resource sustainability. This research provides a comprehensive analysis of the factors contributing to the decline in groundwater levels (GWL) withi

HMGCR and rosuvastatin regulates GLP-1 secretion and expression - a translational study

CONTEXT: Statin use is associated with increased risk of type 2 diabetes and mild hyperglycemia. The underlying mechanisms are not well studied and the effect of statin treatment on GLP-1 secretion or production are unknown.OBJECTIVE: To assess the effects of rosuvastatin on GLP-1 secretion and production.METHODS: We performed association studies in the Malmö Diet and Cancer study cardiovascular c

Association between metabolic conditions, physical activity and self-efficacy before and after a first-line exercise and education intervention for osteoarthritis : a longitudinal register study using the SOAD cohort

Objectives To investigate the association of diabetes, hypertension and overweight/obesity with physical activity (PA), self-efficacy for pain and self-efficacy for other symptoms before and after a 6- week exercise and education intervention for knee and hip osteoarthritis (OA), and to assess outcome disparities based on metabolic health. Methods Register-based cohort study using the Swedish Oste

Aerosol, Clouds and Trace Gases Research Infrastructure (ACTRIS): The European Research Infrastructure Supporting Atmospheric Science

The Aerosol, Clouds and Trace Gases Research Infrastructure (ACTRIS) officially became the 33rd European Research Infrastructure Consortium (ERIC) on 25 April 2023 with the support of 17 founding member and observer countries. As a pan-European legal organization, ACTRIS ERIC will coordinate the provision of data and data products on short-lived atmospheric constituents and clouds relevant to clim

LIGHT/TNFSF14 Levels in Carotid Plaques Are Associated With Symptomatic Cerebrovascular Disease

Background and Purpose Plaque rupture is the underlying cause of most cardiovascular events, such as stroke and myocardial infarction. The co-stimulatory molecule LIGHT (tumor necrosis factor superfamily member 14, TNFSF14) has been detected in foam cell-rich regions of atherosclerotic plaques, but whether it has a role in plaque stability is not known. This study investigates the association betw

Characterization of occupational exposure to air pollutants during asphalt milling and paving

OBJECTIVES: Asphalt is frequently used as road pavement and consists of bitumen as a binder, and fillers. Bitumen consists of a complex mixture of hydrocarbons, where a minor component is polycyclic aromatic hydrocarbons (PAHs). Many PAHs are classified as carcinogenic to humans. Bitumen fumes from road paving have been classified as possibly carcinogenic. Paving and milling are open processes gen

Floating charges in the Nordic countries

This chapter analyses floating charges in the Nordic countries, focusing on Denmark, Norway, Sweden and Finland. Nordic property laws are known for their functional approach, and while property law rules in the Nordic countries are generally fragmentary, Nordic security rights laws are more codified. The four Nordic countries all have floating charges (or equivalent security rights). The chapter d

The role of metabolic syndrome in osteoarthritis development : Is obesity the key driver?

Objective: Investigate the role of metabolic syndrome and obesity in incident osteoarthritis (OA). Methods: Prospective cohort study with up to 11 years follow-up. From a general population cohort of 28,786 individuals from Sweden aged 45 to 75, we selected individuals without OA diagnosis and without joint pain during the year prior to the baseline. Metabolic syndrome was defined at baseline by t

Genome-wide association analyses highlight the role of the intestinal molecular environment in human gut microbiota variation

Despite the importance of the gut microbiome to health, the role of human genetic variation in shaping its composition remains poorly understood. Here we report genome-wide association analyses of harmonized metagenomic data from 16,017 adults in four Swedish population-based studies, with replication in 12,652 people from the Norwegian HUNT study. We identified variants in the OR51E1–OR51E2 locus

Flower color variation in Digitalis purpurea : Pollination and soil influences across native and introduced populations

Premise: Flower color, a key trait influencing plant–pollinator interactions, may be influenced by abiotic factors such as soil. We investigated association between pollinators, soil characteristics, and flower color variations in Digitalis purpurea across native populations in Sweden and introduced populations in Bolivia. Methods: We measured floral traits, reflectance of petals and nectar-guide

Fall risk screening in older persons using a wearable sensor in free-living conditions – A pilot and feasibility study

Introduction: Wearable sensors measuring bodily movements used in free-living conditions may help predict falls in older persons. Assessing their use in this context is essential to identify potential challenges related to fall risk screening. Therefore, this study aimed to assess the feasibility of conducting a prospective study comparing self-rated and wearable sensor-based measures for the asse

Association between the gut microbiota and estimated glomerular filtration rate in two Swedish population-based cohorts

Introduction: Evidence for gut–kidney interactions in early kidney disease is limited, particularly in community-dwelling adults with largely preserved kidney function. Here, we quantified links between gut microbiota and estimated glomerular filtration rate (eGFR) in two population-based Swedish cohorts. Methods: Deep shotgun metagenomics profiled fecal samples from 9788 adults in the Swedish CAr

Kernel-based predictive framework for groundwater level forecast in semiarid areas : a CEEMDAN-based GWO-KELM hybrid mode

Accurate prediction of groundwater levels (GWL) is essential for effective and sustainable water resource management, particularly in arid and semiarid regions where excessive extraction and climate change significantly accelerate aquifer depletion. The nonstationary characteristics of groundwater data pose significant challenges to the performance and reliability of conventional machine learning