Filetype
Background. To characterize participant reasons for withdrawing from a diabetes focused longitudinal clinical observational trial (TEDDY) during the first three study years. Methods. 8677 children were recruited into the TEDDY study. At participant withdrawal staff recorded any reason parents provided for withdrawal. Reasons were categorized into (1) family characteristics and (2) protocol reasons
Background: nonacog beta pegol (N9-GP) is a glycoPEGylated recombinant factor IX (rFIX) molecule with a prolonged half-life. Objectives: To provide information on potential dose regimens for N9-GP for phase 3 pivotal and surgery trials. Methods: A population pharmacokinetic model was developed from single-dose data derived from the first human dose trial with N9-GP in hemophilia B patients, and wa
POU5F1 has two alternatively spliced transcripts: a long (variant 1, NM_002701) and a short (variant 2, NM_203289) transcript. Only variant 1 is a key regulator of pluripotency. Hence, it is important to be able to distinguish this transcript from variant 2 and from the many pseudogenes present in the genome. Previous studies on the expression of POU5F1 were, however, usually carried out without c
Study Type - Diagnostic (case series) Level of Evidence 4 What's known on the subject? and What does the study add? It is well known that CIS is a major risk factor for muscle-invasive bladder cancer and that this entity can be difficult to diagnose. Taking cold-cup mapping biopsies from different areas of the bladder (BMAP) is commonly used in patients at risk of harbouring CIS. The diagnostic ac
Abstract is not available
This paper suggests reasons why an organisation starts the process of reorganising software applications hosting and how these reasons are connected with resilience in software applications used and in business processes. The decision investigated is a sourcing decision process in a Swedish municipality. The main reason for starting the sourcing decision process was that the municipality needed to
Most nuclear medicine clinicians use only visual assessment when interpreting regional cerebral blood flow (rCBF) from single-photon emission computed tomography (SPECT) images in clinical practice. The aims of this study were to develop a new, easy to use, automated method for quantification of rCBF-SPECT and to create normal values by using the method on a normal population. We developed a 3-dim
Although the direction of loads applied to the proximal human femur is unpredictable during sideways fall, most in vitro and numerical simulations refer to a single loading condition (15° internal rotation; 10° adduction), which has been anecdotally suggested in the 1950s. The aim of the present study was to improve in vitro simulations of sideways falls on the proximal femur. An in vitro setup w
Human cystatin C is considered the physiologically most important inhibitor of endogenous papain-like cysteine proteases. We present here an unexpected function of cystatin C. Instead of acting as an inhibitor, cystatin C acts as a facultative, endogenous cofactor for the papain-like IgG-cleaving enzyme IdeS of the human pathogen Streptococcus pyogenes. IdeS activity is not dependent on cystatin C
PURPOSE: To report an alternative to the fenestrated stent-graft for preserving blood flow to side branches in the sealing zones of aortic stent-grafts. TECHNIQUE: A covered stent is deployed parallel to the main aortic stent-graft, protruding somewhat proximally, like a chimney, to preserve flow to a vital side branch covered by the aortic stent-graft. Use of a chimney graft makes it possible to
Popular Abstract in Swedish Magnetkameran är ett diagnostiskt instrument med vilket man kan ta skiktbilder av kroppen. Den började användas i sjukvården för drygt 20 år sedan och baseras på ett fysikaliskt fenomen som kallas för kärnmagnetisk resonans (MR). Detta innebär att vissa atomkärnor som placeras i ett starkt magnetfält kan avge en radiosignal när de utsätts för korta radiopulser. RadiosigContrast-enhanced magnetic resonance angiography (CE-MRA) is a diagnostic method for imaging of vascular structures based on nuclear magnetic resonance. Vascular enhancement is achieved by injection of a contrast medium (CM). Studies were performed using two different types of CM: conventional paramagnetic CM, and a new type of CM based on hyperpolarized (HP) nuclei. The effects of varying CM con
Popular Abstract in Swedish Stroke är en heterogen sjukdom som inkluderar främst hjärninfarkt samt hjärn- och hjärnhinneblödningar från sprucken pulsåderbråck. Stroke är den tredje största dödsorsaken i industriländerna efter hjärtinfarkt och cancer. Varje år drabbas t.ex. i USA cirka 700 000 personer av stroke och runt 230 000 av dessa är fatala. Behandlingsmöjligheterna är trots framsteg på senaIncreasing [K+]o is intimately coupled to progressive ischemia and reduced CBF. In isolated cerebral and mesenteric arteries, it was found that significant differences in the vascular responses to [K+]o exist. Among the species studied, human cerebral arteries were the most sensitive artery to increasing [K+]o. Rabbit basilar arteries, denuded from the endothelium, showed increased sensitivity to
One of the major challenges in analytical chemistry is to find techniques and methods for determinations of low abundance compounds in complex sample matrices. This thesis describes the development of new miniaturised analytical techniques comprising capillary electroseparation combined with mass spectrometric detection. The techniques are rapid, sensitive, efficient, and suitable even for analyte
Denna rapport är resultatet av en litteraturstudie kring råd och riktlinjer för utformning av cykel-infrastruktur med avseende på korsningspunkter med motorfordonstrafik. Referenser har hämtats från handböcker i främst Sverige, Danmark, Nederländerna, Storbritannien och Tyskland samt från relevant forskning där sådan funnits tillgänglig. Studien visar att fokus i dessa råd och riktlinjer ligger på
This thesis looks at present-day ecclesial use of the Bible by investigating the reception of narrative parables from the Gospel of Luke, chapters 10–15, in sermon guidelines published 1985–2013 in two periodicals aimed mainly at Church of Sweden clergy. The main problems can be expressed by the words “what”, “how” and “why”: What is received – and what is not received? How is that which is receiv
This publication has no abstract.
