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Background: The understanding of inhaled particle respiratory tract deposition is a key link to understand the health effects of particles or the efficiency for medical drug delivery via the lung. However, there are few experimental data on particle respiratory tract deposition, and the existing data deviates considerably when comparing results for particles > 1 μm. Methods: We designed an experim

We present a combination of optical operando techniques that allow us to bridge the pressure gap in heterogeneous catalysis. By combining Polarization Modulated - InfraRed Reflection Absorption Spectroscopy (PM-IRRAS) with two dimensional-Surface Optical Reflectance (2D-SOR) and Planar Laser Induced Fluorescence (PLIF), we can simultaneously measure the adsorbed species on the catalyst surface, mo

Molecular junctions offer significant potential for enhancing thermoelectric power generation. Quantum interference effects and associated sharp features in electron transmission are expected to enable the tuning and enhancement of thermoelectric properties in molecular junctions. To systematically explore the effect of quantum interferences, we designed and synthesized two new classes of porphyri

Objective: This study aimed to compare cumulative [fresh and frozen embryo transfers from one ovarian stimulation (OS) cycle] pregnancy and live birth rates in women for whom the choice between recombinant FSH (rFSH) and urinary FSH (uFSH) for OS was linked to FSH receptor (FSHR) N680S genotype and compared these to non-genotyped controls.Methods: To define the optimal combination of FSH type and

Two-dimensional neuronal cultures have a limited ability to recapitulate the in vivo environment of the brain. Here, we introduce a three-dimensional in vitro model for human glia-to-neuron conversion, surpassing the spatial and temporal constrains of two-dimensional cultures. Focused on direct conversion to induced dopamine neurons (iDANs) relevant to Parkinson disease, the model generates functi

Recent epidemiological studies have suggested a positive association between ultra-processed food consumption and breast cancer risk, although some studies also reported no association. Furthermore, the evidence regarding the associations between intake of food with lower degrees of processing and breast cancer risk is limited. Thus, we investigated the associations between dietary intake by degre

A high turnover among principals may disrupt the continuity of leadership and negativelyaffect teachers and, by extension, the students. The aim was to investigate to what extent variouswork environment factors and signs of exhaustion were associated with reported intentions tochange workplace among principals working in compulsory schools. A web-based questionnaire wasadministered twice, in 2018

Reactive oxygen species (ROS) are considered to be an indicator of particle-induced toxicity. We used a novel instrument, called Particle Into Nitroxide Quencher (PINQ), for real-time quantification of ROS for assessment of indoor particle sources. Of the sources tested, cigarette smoke was found to contain the highest ROS concentration, several times higher than incense smoke and secondary organi

Outcome under-ascertainment, characterized by the incomplete identification or reporting of cases, poses a substantial challenge in epidemiologic research. While capture-recapture methods can estimate unknown case numbers, their role in estimating exposure effects in observational studies is not well established. This paper presents an ascertainment probability weighting framework that integrates

Crystal Phase Quantum Dots (CPQDs) offer promising properties for quantum communication. How CPQDs can be formed in Au-catalyzed GaAs nanowires using different precursor flows and temperatures by in situ environmental transmission electron microscopy (ETEM) experiments is studied. A III-V gas supply system controls the precursor flow and custom-built micro electro-mechanical system (MEMS) chips wi

We have previously proposed and evaluated acoustophoresis for the enrichment of circulating tumor cells (CTC) and clusters thereof from the blood of patients with prostate cancer [1]. In that protocol, the cells were fixed and preserved in paraformaldehyde before processing and were thus non-viable. To enable future enrichment of also viable CTCs from patients, we have in this study investigated t

We recently introduced the concept of thermoacoustic streaming in microchannels wherein a thermal field is generated inside an acoustic cavity. The result is a fast and controllable streaming for which the thermal energy is provided either by an LED light source [1], or a laser [2]. While in previous works we have measured this effect at steady state, we now present measurements of the build-up an

By combining acoustic fields and liquid flows in microchannels we develop tools to chart and separatebiological particles based on their bio-mechanical properties. I will present an overview of three ongoingprojects where acoustic forces are utilized to separate blood cells.We studied the packing behavior of whole blood in a sound field. We discovered that cells self-organizesuch that red blood cells

Pulmonary tuberculosis (TB) causes progressive and irreversible damage to lung tissue, a damage that may not fully resolve after treatment. Mycobacterial vesicles (MVs), which are poorly understood, may contribute to TB pathology. This study investigated the effects of stress, such as treatment with conventional TB antibiotics rifampicin, isoniazid, ethambutol, or treatment with an antimycobacteri

Direct thermal-to-electric energy converters typically operate in the linear regime, where the ratio of actual maximum power relative to the ideal maximum power, the so-called fill factor (FF), is 0.25. Here, we show, based on fundamental symmetry considerations, that the leading order nonlinear terms that can increase the FF require devices with broken spatial symmetry. Studying nonlinear, thermo

BACKGROUND: Perfluoroalkyl substances (PFAS) have been associated with impaired antibody levels after childhood vaccinations and immunosuppressive effects in animals. However, the in vivo effects of PFAS on antigen specific human T cell responses have not been investigated in adults. In Ronneby, Sweden, the drinking water of one of the water works was previously highly contaminated with primarily

Metal-halide perovskites (MHPs) have gained substantial interest in the energy and optoelectronics field. MHPs in nanostructure forms, such as nanocrystals and nanowires (NWs), have further expanded the horizons for perovskite nanodevices in geometry and properties. A partial anion exchange within the nanostructure, creating axial heterojunctions, has significantly augmented the potential applicat

Extracellular plaques in Alzheimer’s disease contain Aβ peptides and ganglioside lipids such as GM1. Aβ monomers self-assemble into beta-sheet-rich fibrils when their concentration exceeds solubility, while GM1 monomers form spherical micelles above their critical concentration. This study examines the self-assembly of Aβ in the first two papers and its co-assembly with GM1 in the last two. In Pap