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Decoding the RNA regulome governing cellular stress responses and cell fate transitions

RNA modifying enzymes play a pivotal role in reshaping gene expression programs in response to diverse intracellular and extracellular cues, thereby maintaining cellular homeostasis. When dysregulated, these enzymes are increasingly implicated in the onset and progression of various diseases. While traditionally recognised for their catalytic functions, mounting evidence suggests that many RNA mod

Cointegration between the Chinese and US stock markets

This paper conducts an empirical study on the relationship between the emerging financial market of China and the developed market of the US, both during and after the 2007-2009 financial crisis. Stock indices from the two countries are analysed to examine whether there exist any comovements between the different equity markets. Econometric time series testing of weekly stock values indicate that

Ekocid - det bortglömda brottet. Om lämpligheten att införa ekocid som ett femte internationellt brott i Romstadgan

Uppsatsen undersöker lämpligheten att införa storskalig miljöförstöring, i form av ekocid, som ett femte internationellt brott i Romstadgan för internationella brottmålsdomstolen som antogs i Rom 1998. Undersökningen görs i förhållande till Romstadgans syfte och målsättning och i förhållande till de brott som utgör kärnan av Romstadgan. Kärnbrotten utgörs av folkmord, brott mot mänskligheten, krigThis essay examines the possibility to make environmental destruction an international crime by including ecocide as a fifth crime against peace in the Rome Statute of the International Criminal Court adopted in Rome in 1998. The issue is examinated in relation to the purpose and objective of the Statue and in relations to the core crimes. The core crimes; crime of genocide, crimes against humanit

Märkning av importerade, färdigförpackade livsmedel i Malmö stad - Uppfyller butikerna Livsmedelsverkets märkningskrav?

Syftet med detta arbete är att undersöka efterlevnaden av lagen gällande märkning av importerade färdigförpackade livsmedel hos livsmedelsbutiker i Malmö. 20 butiker studerades. Vid besöken granskades dels märkning av ett antal importerade färdigförpackade livsmedel, och dels utfördes enkätundersökning kring butikens livsmedelsmärkning och märkningsrutiner. Enkätundersökningen besvarades vanligtvThe purpose of this thesis is to examine the compliance of the labeling law of imported prepackaged foods in grocery stores in Malmö. 20 stores were studied. During the visits the labels of a number of imported pre-packaged foods were examined, and there was also a survey conducted about the store's food labels and their labeling rutines. The survey was usually answered by the owner or store

Comparative infectivity, virulence and molecular epidemiology of MDR and XDR Acinetobacter baumannii isolates emerging from war-related injuries in Ukraine

BACKGROUND: Multidrug resistant Acinetobacter baumannii remains a global concern with its ability to adhere, disperse and sustain in areas involving suboptimal infection control measures, particularly in war areas. In this study we aimed to evaluate the susceptibility profiles, molecular epidemiology and pathogenesis of A. baumannii isolates from conflict zones in Ukraine.METHODS: A. baumannii wou

Formation of intermediate-phase free ultrasmooth quasi-two-dimensional perovskite films for high quality lasers

Ultrasmooth solution-processable quasi-2D perovskite thin films are of critical importance for many optoelectronic devices. In this work, we fabricated an ultrasmooth intermediate-phase free quasi-2D (PEA)2(FA)n−1PbnBr3n+1 perovskite film by using antisolvents with different polarities and boiling points to engineer the crystallization process. The XRD patterns of the perovskite powder showed that

Nya klassifikations­kriterier för antifosfolipidsyndrom

The new ACR/EULAR classification criteria for APS differ from the previous Sydney criteria by incorporating a broader range of clinical manifestations beyond venous/arterial thromboembolism and obstetric complications. These include microvascular disease, heart valve disease and thrombocytopenia. We applied both classification systems to a cohort of 139 individuals diagnosed with primary APS in So

Validating the Depression Anxiety Stress Scales-21 in Community Mothers and Fathers Across the Infant's First Year

BACKGROUND: To investigate the effects of different types of parental health status on child development and health, valid parental distress measurement instruments are needed. The aim was to assess the psychometric measurement properties of the 21-item Depression Anxiety Stress Scales (DASS-21) used during the postnatal year in community samples of Swedish mothers and fathers.METHODS: Data were c

Regenerative performance and immunogenicity of engineered extracellular matrices.

Critical-sized bone defects remain a significant unmet clinical need, with > 500,000 reconstructive procedures performed annually in the United States and Europe and associated costs exceeding US$3 billion. Autologous bone grafting—the current gold standard—suffers from limited harvest volume and donor-site morbidity, whereas allografts show variable integration and carry immunological and infecti

Swedish study participants undergoing research bronchoscopy - a tolerable or unpleasant experience?

INTRODUCTION: Flexible bronchoscopy is regarded as a safe examination and is commonly used in the diagnostic work-up for lung diseases, but is also important in pulmonary research. We aimed to investigate participants' experiences when undergoing bronchoscopy in a research setting.METHODS: Participants were recruited from the Swedish CArdioPulmonary bioImage Study (SCAPIS). A subset from this coho

Heparan sulfate N-deacetylase/N-sulfotransferase-1 regulates glioblastoma cell migration and invasion

The glioblastoma (GBM) microenvironment undergoes adaptations to support tumor progression, including a dysregulated extracellular matrix, with altered heparan sulfate (HS) proteoglycans. We investigated N-deacetylase/N-sulfotransferase-1 (NDST1) because NDSTs are initial modifying enzymes of HS biosynthesis and have key roles in designing the HS sulfation pattern. This, in turn governs interactio

Urban pollution impact assessment in six lithuanian cities with a focus on road traffic emissions - integrated framework for environmental health studies

An integrated framework is introduced and applied to assess the health impact of airborne pollution with greater physiological relevance, moving beyond conventional exposure metrics. Measured particle number size distribution data was integrated with a regional respiratory tract deposition fractions to estimate total and alveolar deposited particle surface area concentrations. Land use regression

Action-detected 2D spectroscopy : Technical development and practical applications

This doctoral thesis presents a comprehensive investigation into action-detected two-dimensional electronic spectroscopy (A-2DES), from the technical development of a state-of-the-art apparatus to its application in elucidating ultrafast dynamics in advanced materials and biological systems. The work is founded on the design and implementation of an A-2DES setup centered on a single acousto-optic

Stimuli-Responsive Electronic Reconfiguration in Benzo(ghi)perylene-TCNQ Donor–Acceptor Crystalline Networks

Template-assisted crystal engineering provides a powerful strategy for constructing ordered networks tailored to organic electronic applications. We introduce a solution-based strategy to fabricate crystalline needle-like arrays of charge-transfer complexes (CTCs) between electron-donating benzo(ghi)perylene (BP) and electron-accepting TCNQ. Well-defined square-crystals of BP polymorphs were emplo

Engineering bimetallic CuAu to suppress hydrogen evolution and enhance charge transfer for improved photoelectrochemical nitrogen reduction

Green ammonia synthesis from nitrogen via photocatalysis and electrocatalysis has emerged as a pivotal research focus in sustainable chemical processes. The efficient catalytic reduction of nitrogen necessitates concurrent nitrogen activation and hydrogen evolution suppression, representing a significant challenge. In this study, CuAu bimetallic-modified TiO2 catalysts were developed and engineere

Advancing Time-Resolved Photoemission Electron Microscopy for Imaging Ultrafast Dynamics

By combining ultrashort laser pulses with PEEM, time-resolved photoemission electron microscopy (TRPEEM) provides a powerful approach for investigating ultrafast charge carrier dynamics with simultaneous femtosecond temporal resolution and nanometer spatial precision. It has evolved into a versatile methodto study a wide range of phenomena, including charge carrier dynamics, surface plasmons, scat

A dephasing sweet spot with enhanced dipolar coupling

Two-level systems (TLSs) are the basic units of quantum computers but face a trade-off between operation speed and coherence due to shared coupling paths. Here, we investigate a TLS given by a singlet-triplet (ST+) transition. We identify a magnetic-field configuration that maximizes dipole coupling while minimizing total dephasing, forming a compromise-free sweet spot that mitigates this fundamen