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Stem cell-based approaches for the treatment of stroke have been the subject of intensive research over the past decade. Based on accumulated experimental evidence, stem cell-based therapy is a very promising prospect for the development of a novel treatment to restore stroke-damaged brain and impaired neurological function. Studies performed on experimental animal models of stroke employed a vari
A greater adherence to the traditional Mediterranean (MED) diet is associated with a reduced risk of developing chronic diseases. This dietary pattern is based on higher consumption of plant products that are rich in flavonoids. We compared the total flavonoid dietary intakes, their food sources and various lifestyle factors between MED and non-MED countries participating in the EPIC study. Flavon
Objective: Parental history of diabetes and specific gene variants are risk factors for type 2 diabetes, but the extent to which these factors are associated is unknown. Methods: We examined the association between parental history of diabetes and a type 2 diabetes genetic risk score (GRS) in two cohort studies from Finland (population-based PPP-Botnia study) and the US (family-based Framingham Of
Background: Air pollution has been linked to breast cancer risk, but previous studies have seldom considered specific exposure windows, like pregnancy. During pregnancy the breast undergoes substantial changes and exposures may have a stronger impact than if they occurred during other time periods. This study aims to identify associations between ambient air pollution exposure during pregnancy and
Extensive genetic and epigenetic variegation has been demonstrated in many malignancies. Importantly, their interplay has the potential to contribute to disease progression and treatment resistance. To shed light on the complex relationships between these different sources of intra-tumour heterogeneity, we explored their relative contributions to the evolutionary dynamics of Acute Lymphoblastic Le
Svenska kommuner befinner sig just nu i en ansträngd ekonomisk situation med både brist på ekonomiska resurser och personal. Samtidigt råder det en efterfrågan på bostäder och i 180 av 290 svenska kommuner råder det ett underskott på bostadsmarknaden. Till följd av den begränsade resurstillgången måste kommunerna därmed prioritera vilket innebär att de måste fördela sina resurser till det som anseSwedish municipalities are currently in a constrained economic situation with a shortage of both financial resources and personnel. The municipalities hold a zoning monopoly, and due to the limited financial resources they have to prioritize within their physical planning to ensure they allocate their resources on what is most important. The aim of this thesis is to create an understanding of how
The question of environmental protection has lately become essential due to the increased number of polluters and accidents that have occurred in recent decades. The starting point was the Torrey Canyon disaster which happened in March 1967 and exposed the entire international community to a great danger of environmental harm in general and marine pollution in particular. The accident also pointed
The increasingly competitive climate has caused companies to pursue counteractive strategies such as M&As in the hope to attain synergy potential. However, M&As are associated with a high failure rate and synergy realization is often unsuccessful. One area poorly covered in previous literature and often unattended by merging parties is synergies within logistics, despite its significance f
In central Budapest, when the city of Pest was developing, urban policy led to small plots built on all four sides mak- ing up the larger neighborhood block structures. Each small lot was centered around its even smaller courtyard, lead- ing to a myriad of small open spaces with little sunlight or activity. Many of these plots today have fallen into disrepair, becoming parking lots or unused p
This thesis investigates buyer preferences in the procurement of Internationally Transferred Mitigation Outcomes (ITMOs) under Article 6.2 of the Paris Agreement, which facilitates international cooperation through carbon markets. As ITMO markets are still in the early stages of development, uncertainties regarding regulatory frameworks, environmental integrity, and procurement strategies have eme
The development of artificial intelligence has led to significant advancements across various fields but is has also introduced considerable challenges. One such challenge is the emergence of so-called deepfakes, which are realistic, yet fabricated images or videos generated by artificial intelligence. A large propor-tion of deepfakes today are sexual in nature, most of which depict women without
The aim of this thesis was to analyze and compare the effects of various types of speed-reducing measures (speed humps, raised pedestrian and cycle crossings, dynamic speed bumps, and combined solutions) on vehicle speeds and traffic safety on selected streets in Helsingborg, Sweden. The study focused on residential streets, school zones, and main roads with different traffic environments. The met
Aims: The objective of this study was to compare the risk of developing type 1 diabetes in individuals with celiac disease, hyperthyroidism and hypothyroidism to that of individuals without those conditions. Materials and Methods: In this retrospective, observational, matched-cohort study based on real-world claims data, individuals with at least one diagnosis of celiac disease, hyperthyroidism (e
Individuals with immigrant background generally perform less well in school than non-immigrants. Performing well in school may decrease the risk of substance use disorder (SUD). We investigated whether higher school performance is associated with a decreased risk of SUD in early adulthood among immigrants and non-immigrants and whether subsequent educational attainment and employment status partly
AIMS/HYPOTHESIS: The incidence of type 1 diabetes increased during the pandemic in various countries. SARS-CoV-2 infections may trigger the development of type 1 diabetes, but the evidence is inconclusive. This study aimed to assess trends in type 1 diabetes incidence between 2007 and 2023, and to quantify the association between SARS-CoV-2 infections and the risk for developing type 1 diabetes.ME
