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Homeostasis of short-lived blood cells is dependent on rapid proliferation of immature precursors. Using a conditional histone 2B-mCherry-labeling mouse model, we characterize hematopoietic stem cell (HSC) and progenitor proliferation dynamics in steady state and following several types of induced stress. HSC proliferation following HSC transplantation into lethally irradiated mice is fundamentall

Conflicting evidence exists regarding the association between saturated fatty acids (SFAs) and type 2 diabetes. In this longitudinal case-cohort study, we aimed to investigate the prospective associations between objectively measured individual plasma phospholipid SFAs and incident type 2 diabetes in EPIC-InterAct participants.

Aims/hypothesis: Genome-wide association studies (GWAS) have identified more than 65 genetic loci associated with risk of type 2 diabetes. However, the contribution of distorted parental transmission of alleles to risk of type 2 diabetes has been mostly unexplored. Our goal was therefore to search for parent-of-origin effects (POE) among type 2 diabetes loci in families. Methods: Families from the

[Context and motivation] Ecosystems developed as Open Source Software (OSS) are considered to be highly innovative and reactive to new market trends due to their openness and wide-ranging contributor base. Participation in OSS often implies opening up of the software development process and exposure towards new stakeholders. [Question/Problem] Firms considering to engage in such an environment sho

Introduction: The gastro-intestinal hormone glucose-dependent insulinotropic polypeptide (GIP) potentiates glucose-induced insulin secretion, with bone anabolic effects through GIP receptor (GIPR) in animal models. We explore its potential in humans by analyzing association between polymorphisms (SNPs) in the GIP and GIPR genes with bone phenotypes in young and elderly women. Methods: Association

Many businesses still put too much focus on manufacturing, marketing and sales without considering the inter-linkages amongst these elements. This paper shows the importance of including packaging logistics and supply chain management in strategic planning. By integrating these aspects, retailers and suppliers may reduce costs, environmental impact and increase profits. A case study at IKEA is use

Technical infrastructures of the society are becoming more and more interconnected and interdependent, i.e. the function of an infrastructure influences the function of other infrastructures. Disturbances in one infrastructure therefore often traverse to other dependent infrastructures and possibly even back to the infrastructure where the failure originated. It is becoming increasingly important

Even though language proficiency in children is strongly related to success in almost all domains, neurocognitive studies of L2 processing are typically limited to adults with several years of exposure, who may use general cognitive mechanisms to compensate for any difficulties in L2 processing. For example, whereas previous studies of adult bilinguals have reported differences in the anterior neg

During the past decade, production of products has increasingly been relocated to countries outside the western industrialised area, while consumption of the same products in the west has increased to a considerable extent. Implementation of national policies for limiting the environmental and health impacts of production has encountered a number of difficulties as a result. Policy instruments, no

Our society is becoming more and more dependent upon the reliable function of a number of vital socio-technical systems. These systems are often being referred to as critical infrastructures, or lifeline systems, indicating their importance for supporting a nation’s economy and social well-being. In the present paper a method is presented for assessing the capability of those actors involved in re

Aspects of labour market integration and employment strategies in relation to reasonable accommodation regulations and the individualised perspective of anti-discrimination legislation. In recent years an unquestionable shift towards disability anti-discrimination legislation can be observed in EC-law (see dir. 2000/78/EC) as well as in national legislations in many parts of the world. Disability