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BACKGROUND: Recent research using a data-driven cluster approach has identified five discordant subclassifying body mass index (BMI) subgroups, characterized by cardiometabolic biomarkers deviated from those predicted by BMI.OBJECTIVE: This study aimed to investigate the associations of these subgroups with risks of metabolic dysfunction-associated steatotic liver disease (MASLD) and liver-related

The purpose of this narrative review is to provide an evidence-based update on management strategies for young adults with meniscal tears, based on two recent randomized controlled trials comparing a surgical vs. non-surgical treatment strategy for this patient group. The results from these trials suggests that exercise therapy is a viable treatment alternative for young adults with a meniscal tea

Background. Adults with intellectual disability (ID) experience marked mental health inequities, yet population-wide estimates that capture both primary- and specialist-care diagnoses remain scarce. Methods. Using nationwide Swedish registries, including primary care, specialist, inpatient, prescription drug, criminal, and suspicion registers, we included all individuals born in Sweden between 195

Background/Objective: Genetic factors contribute significantly to Parkinson’s disease (PD), especially in cases with early onset or positive family history. However, previous investigations of the genetic landscape in PD populations were mainly based on targeted genotyping. The aim of this study was to investigate the prevalence of pathogenic variants in known PD-associated genes in a series of Sw

Purpose: Host factors, including genetic factors, are underutilized in breast cancer treatment selection. This study aimed to investigate AIB1 genotypes as pharmacogenetic markers for adjuvant breast cancer treatment. The prognostic impact of three functional polymorphisms associated with altered mRNA expression rs6094752 (low expression), rs2230782 (low expression) and rs2076546 (high expression)

Aim: An electrocardiogram is commonly recommended in breath-holding spell management, mainly to rule out long QT syndrome. This retrospective study investigated the risk of long QT syndrome being misdiagnosed as breath-holding spells in a paediatric population in southern Sweden. Methods: Data on patient characteristics and diagnostic findings were reviewed for patients aged < 10 years who were di

Denna uppsats behandlar frågan om när sjukdom kan utgöra sakliga skäl för uppsägning enligt 7 § lagen (1982:80) om anställningsskydd (LAS). Utgångspunkten i svensk arbetsrätt är att sjukdom i sig inte utgör grund för uppsägning. Syftet är därför att klarlägga under vilka förutsättningar sjukdom ändå kan leda till en rättsenlig uppsägning. Uppsatsen bygger på en rättsdogmatisk metod där lagtext, föThis essay examines under what circumstances illness may constitute objective grounds for dismissal under Chapter 7, Section 1 of the Swedish Employment Protection Act (1982:80). The starting point in Swedish labour law is that illness as such does not justify dismissal. The purpose of the study is therefore to clarify the legal conditions under which illness may nonetheless result in a lawful ter

AIMS: Diagnosing heart failure with preserved ejection fraction (HFpEF) remains challenging, particularly in older individuals. We hypothesized that machine learning (ML) approaches could improve diagnostic accuracy compared with HFpEF scores.METHODS: We evaluated the diagnostic performance of four supervised ML algorithms (random forest [RF], extreme gradient boosting [XGBoost], support vector ma

BACKGROUND: Neurointensive care is moving toward more automated patient management. This study aimed to evaluate a novel external ventricular drainage (EVD) system, the VGuard® system, as a tool for intracranial pressure (ICP) monitoring and automating ventricular drainage of cerebrospinal fluid (CSF), focusing on its safety and potential to reduce complications associated with manual EVD manageme

Antimicrobial resistance in pathogenic mycobacteria remains a critical challenge due to poor drug penetration through their complex cell wall, which necessitates prolonged multidrug regimens. Mycobacteriophages encode a lytic machinery that can disrupt this barrier. In this research article, we describe a modular mycolysin platform combining phage enzymes Lysin A and Lysin B with outer membrane-pe

In low-and middle-income countries, inadequate sanitation results in faecal contamination of the water used by urban farmers for irrigation. Consumers of raw contaminated vegetables run the risk of developing diarrhoeal diseases and helminth infections, which are a leading cause of under-five mortality and impact the well-being and productivity of millions of adults. This review identifies the evi

Background: The incidence, aetiology, and outcome of unplanned intensive care unit admission after elective colon cancer surgery remain unclear. This study investigated the incidence of, and factors associated with, unplanned intensive care unit admission following elective colon cancer resection in Sweden. Methods: This nationwide retrospective registry study included adult patients undergoing el

This meta-analysis and systematic review examined the effects of psychedelic substances on death anxiety, specifically evaluating whether psychedelic experiences are associated with statistically significant reductions in death anxiety. A systematic search identified 8 studies suitable for meta-analysis and 10 additional studies for systematic review. Using a random-effects model, the meta-analysi

Wide-angle neutron scattering analysed using empirical potential structure refinement (EPSR) was used to investigate how aromatic ring structure influences micelle self-assembly in two anionic surfactants: sodium 4-heptylbenzene sulfonate (SHBS) and sodium 5-heptylfuran-2-sulfonate (SHFS). Both surfactants formed globular micelles in aqueous solutions at 0.2 M but differed significantly in micelle

Objectives: To evaluate the impact of the 2018 switch from PCV13 to PCV10 in Sweden’s childhood immunisation programme on the serotype distribution of Streptococcus pneumoniae.MethodsRespiratory tract (RT) S. pneumoniae isolates (n=1615; 2020–2023) were serotyped, tested for antimicrobial susceptibility and compared with invasive pneumococcal disease (IPD) isolates (n=397) and PCV13-era data (2016