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BackgroundThe clinical standard practice of [177Lu]Lu-PSMA-617 therapy is a single injection per treatment cycle, with 6 weeks between cycles. While clinical schedules currently utilize single-bolus cycles, splitting a treatment cycle into multiple smaller injections has demonstrated benefits in other radionuclide therapies, preclinically and in clinical studies. Potential mechanisms for improved

BACKGROUND Clonal hematopoiesis of indeterminate potential (CHIP) and clonal cytopenia of undetermined significance (CCUS) are defined by somatic mutations in genes associated with myeloid neoplasms (MN) at a variant allele fraction (VAF) of 0.02 or greater in the absence and presence of cytopenia, respectively. CHIP/CCUS is highly prevalent in adults, and defining predictors of MN risk would aid

Background: Breast cancer polygenic risk scores (PRS) and traditional risk models (e.g., the Gail model [Gail]) are known to contribute largely independent information, but it is unclear how the overlap varies by ancestry, age, disease type (invasive breast cancer, DCIS), and risk threshold. Methods: In a retrospective case–control study, we evaluated risk prediction performance in 180,398 women (

This thesis examines whether more generous unemployment insurance is associated with greater household portfolio risk-taking in Europe by reducing background income risk. Using a largely balanced panel of European countries, the analysis measures household risk-taking as the share of household financial assets held in equity and investment fund shares. Unemployment insurance generosity is proxied

Hedgehog (Hh) signaling is essential for embryonic development and tissue homeostasis in organisms. However, Caenorhabditis elegans lacks canonical Hh signaling due to the absence of key components, such as smoothened (SMO) and obvious Hh ligands. Despite this, C. elegans retains Patched homologs, ptc-1 and ptc-3, which have specialized independent functions. Although ptc-1 is predominantly ex

Taurine, an amino sulfonic acid abundant in seafood and meat, has been proposed to have a potential role in the prevention of metabolic dysfunction-associated steatotic liver disease (MASLD) due to its antioxidant and anti-inflammatory properties. However, the association between dietary taurine intake and MASLD remains unclear in human populations. Also, data on dietary taurine intake among adult

Background: Standardized definitions of autoimmune disease (AD) are lacking. Therefore, we aim to propose a definition of AD for register-based research and estimate the burden of AD in Sweden as registered in the National Patient Register (NPR) from 1980 to 2023. Methods: Leveraging the NPR, we defined AD as having at least two relevant International Classification of Diseases (ICD) codes represe

Background: The use of high-flow oxygen therapy (HFOT) compared with standard low-flow oxygen therapy (LFOT) may improve outcomes in people with oxygen-dependent chronic respiratory failure (CRF). The primary aim of this multicentre trial was to evaluate HFOT in addition to LFOT, compared with regular LFOT in people with CRF due to chronic obstructive pulmonary disease (COPD) or interstitial lung

An abdominal aortic aneurysm (AAA) is defined as aortic diameter ≥30 mm measured by ultrasound. AAA prevalence increases with age and is higher in men, but has decreased during the last decades, related to lower smoking rates. Tobacco smoking, concomitant atherosclerosis, arterial hypertension, and family history are the most common risk factors. AAA has atherosclerotic, inflammatory, apoptotic, a

Antipsychotic drugs (APD) are commonly prescribed to people living with dementia (PwD) to manage behavioral and psychological symptoms of dementia (BPSD), despite well-documented safety concerns. International guidelines recommend non-pharmacological interventions as first-line treatment, yet APDs remain widely used. This systematic review and meta-analysis synthesize current evidence on the conse

Tryptophan is an essential amino acid for the human body and is crucial for protein synthesis. It is primarily metabolized through the kynurenine, 5-hydroxytryptamine, and indole pathways. The various bioactive compounds produced through tryptophan metabolism can regulate a range of physiological functions, including digestive, metabolic, immune responses, and neurological functions. New evidence

The role of genomic variants in disease has expanded significantly with the advent of advanced sequencing techniques. The rapid increase in identified genomic variants has led to many variants being classified as Variants of Uncertain Significance or as having conflicting evidence, posing challenges for their interpretation and characterization. Additionally, current methods for predicting pathoge

Since the 1980s, financial deregulation and welfare cuts have driven an economic risk shift, requiring individuals to take greater financial responsibility through private savings in stocks and mutual funds. An unexplored aspect of this “financialization of everyday life” is the personal finance advice provided by experts employed by banks and other market-oriented actors. This study examines fina

Clonal hematopoiesis of indeterminate potential (CHIP) is characterized by age-related somatic mutations in hematopoietic stem and progenitor cells (HSC/Ps) and is correlated with an increased risk of myeloid malignancies, elevated inflammatory pathways in circulating myeloid cells, higher all-cause mortality, chronic kidney disease, and cardiovascular disease. The pathophysiology of inflammatory

COSM52_Literature List Mandatory readings: 678 pages Presenter readings: 355 pages Altman, Dennis. "Global gaze/global gays."  GLQ: A journal of Lesbian and Gay Studies  3, no. 4 (1997): 417-436. > Pages to read for students: 20 > Available at LUBsearch Ames, Chris. “Crossfire Couples: Marginality and Agency among Okinawan Women in Relationships with U.S. Military Men.” In  Over there: Living with

https://www.ht.lu.se/media/utbildning/dokument/kurser/COSM52/20252/COSM52_literature_list_2025.docx - 2026-05-21

Insikt och Handling 3 INSIKT OCH HANDLING Utgiven av Hans Larsson Samfundet Volym 3 REDAKTÖR: ROLF EKMAN DISTRIBUTION: AB PH. LINDSTEDTS UNIV.-BOKHANDEL TRYCKNING: SKÅNSKA CENTRALTRYCKERIET, LUND 1960 ISSN 0436-8096 PDF: TABULA, MÄRSTA 2020 ISBN: 978-91-88702-13-5 VERSION 1.0 — 2020-05-14 – 2 – Innehåll 4 Johannes av Salisbury En humanist från 1100-talet Gunnar Aspelin 17 Bhagavadgîtâ Walther Eidl

https://www.fil.lu.se/fileadmin/user_upload/fil/dokument/hanslarsson/Insikt_och_handling_vol_3.pdf - 2026-05-28

August 2021 ISBN 978-91-86910-46-4 Editors Şebnem Keniş and Meena Shivdas Authors Yang Fan, Asrat Adugna Jimma, Şebnem Keniş, Mavis Thokozile Macheka, Kundai Nhongo, Tirsit Sahledengil, Munatsi Shoko, Boravin Tann, Sophorn Tuy, Liu Xiaonan, Hao Yang, Feng Yuan Project team Evgeniya Mazanik, Mastibegim Milikbekova, Şebnem Keniş, Meena Shivdas Copyediting Robert Parkin Graphic design Nikita Lourenco

https://rwi.lu.se/wp-content/uploads/2021/12/Gender-and-HR-in-the-context-of-Covid-19-pandemic-v2-1.pdf - 2026-05-28