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In the software industry, the drive to add new features often overshadows the need to improve existing code. Large Language Models (LLMs) offer a new approach to improving codebases at an unprecedented scale through AI-assisted refactoring. However, LLMs come with inherent risks such as braking changes and the introduction of security vulnerabilities. We advocate for encapsulating the interaction
Logs are prevalent in modern cloud systems and serve as a valuable source of information for system maintenance. Over the years, many supervised, semi-supervised, and unsupervised log analysis methods have been proposed to detect system anomalies. In particular, semi-supervised methods have garnered increasing attention as they balance reduced labeled data requirements and optimal detection perfor
Background: Testicular torsion (TT) is a scrotal emergency that needs urgent detection for successful treatment. Purpose: To investigate the diagnostic value of acute ultrasound and the possibility of more effective detection. Material and Methods: This retrospective study included patients assessed with ultrasound for suspicion of TT between 2019 and 2023. Registration of parameters included symp
Pixel sensors in 3D technology equip the outer ends of the staves of the Insertable B Layer (IBL), the innermost layer of the ATLAS Pixel Detector, which was installed before the start of LHC Run 2 in 2015. 3D pixel sensors are expected to exhibit more tolerance to radiation damage and are the technology of choice for the innermost layer in the ATLAS tracker upgrade for the HL-LHC programme. While
Military cultural competency involves understanding the unique needs of military and veteran (MV) populations. Research shows that culturally competent care improves health outcomes, yet little is known about civilian sexual assault centers (SACs) supporting MV clients. Many MV clients affected by military sexual trauma (MST) seek community services due to mistrust of the military system. This stu
This study investigates the integration of Large Language Models with the TRIZ to improve problem solving and innovation in industrial product development. By combining the structured problem-solving framework of TRIZ with LLMs to process large amounts of data and generate ideas, this hybrid approach seeks to overcome the limitations of traditional TRIZ and optimize solution generation. In a case
A magainin derivative, designated MSI-344, was produced in Escherichia coli as fusion protein, by utilizing a truncated amidophsphoribosyltransferase of E. coli as a fusion partner. Bacterial cells transformed with the gene encoding the fusion protein were grown to a high cell density and induced with isopropyl-1-thio-b-D-galatoside (IPTG) to initiate product expression. The fusion protein was
In some ways, it can feel like conducting empirical research has become more and more difficult. Some standards that were widely agreed upon in the past for conducting research on gender and/or sex appear to be contested today (see Fraser, 2018). Some questions that may feel uncontroversial to ask for some research participants are a source of minority stress, exclusion, and outrage for others. Ca
The local average treatment effect (LATE) estimator has enabled a wide range of empirical studies that usenatural experiments to estimate causal effects from observational data. However, this empirical literature has overlooked a crucial assumption regarding the definition of the treatment—thepart of the stable unit treatment value assumption referred to asthe consistency assumption in epidemiolog
Pregnant women have historically and are currently being excluded from cervical cancer screening in most low and middle-income countries (LMICs). The aim of this study was to assess the feasibility and outcomes of including pregnant women in a HPV self-sampling-based screening program in Ethiopia. Pregnant women, recruited from a previously established cohort, were included. They answered a questi
The emergence of antibiotic resistance necessitates effective strategies for evaluating antimicrobial agents. Bioluminescent bacteria, either naturally occurring or engineered with modified reporter genes like bacterial luciferase, provide real-time assessment of bacterial viability through light emission. We investigated the antibacterial effects of cefotaxime and doxycycline using bioluminescent
Currant, and in particular blackcurrant, Ribes nigrum, is widely grown in Europe. It is the host of a number of pest insects, but their occurrence and the damage they cause vary geographically. In northern Europe, three lepidopteran species, the currant shoot borer (Lampronia capitella), the currant clearwing (Synanthedon tipuliformis), and the currant bud moth (Euhyponomeutoides albithoracellus),
When children exercise their right to political participation through climate activism and litigation, they demonstrate that an ethics of care is a core component of the postpaternalist era. Children’s ethics of care, however, is not only about care toward their immediate human relations, but also toward other species, the environment they live in and generations to come. They thereby develop the
Background: Recently developed buprenorphine depot injections have the potential to reduce risk for diversion and misuse, and to increase adherence with fewer visits for supervised intake. However, it is unclear how patients perceive this new form of medication. The purpose of this study was to explore patients experiences of depot injections and their reasons for continuing, discontinuing, or dec
Coherent Diffraction Imaging (CDI) is an experimental technique to image isolated structures by recording the scattered light. The sample density can be recovered from the scattered field through a Fourier Transform operation. However, the phase of the field is lost during the measurement and has to be algorithmically retrieved. Here we present SPRING, an analysis framework tailored to X-ray Free
Diamine oxidase (DAO) is an enzyme involved in the regulation of cell proliferation and the immune response. This enzyme performs oxidative deamination in the catabolism of biogenic amines, including, among others, histamine, putrescine, spermidine, and spermine. The mechanistic details underlying the reductive half-reaction of the DAO-catalyzed oxidative deamination which leads to the reduced enz
The epoxide hydrolase StEH1 catalyzes the hydrolysis of trans-methylstyrene oxide to 1-phenyl-propane-1,2-diol. The (S,S)-epoxide is exclusively transformed into the (1R,2S)-diol, while hydrolysis of the (R,R)-epoxide results in a mixture of product enantiomers. In order to understand the differences in the stereoconfigurations of the products, the reactions were studied kinetically during both th
