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Personalized diagnosis in suspected myocardial infarction

Background: In suspected myocardial infarction (MI), guidelines recommend using high-sensitivity cardiac troponin (hs-cTn)-based approaches. These require fixed assay-specific thresholds and timepoints, without directly integrating clinical information. Using machine-learning techniques including hs-cTn and clinical routine variables, we aimed to build a digital tool to directly estimate the indiv

Arts and culture engagement for health : a Danish population-based study

Objectives: Global health challenges are complex and new approaches are pivotal. Engagement in arts and cultural activities is commonplace across different cultures, and research shows associations with benefits for health and wellbeing. Using the arts for health promotion and prevention of illness has increased worldwide. Study design: A population-based study. Methods: Data were obtained from th

Emergency department crowding and mortality : an observational multicenter study in Sweden

Background: Emergency department (ED) crowding is a serious problem worldwide causing decreased quality of care. It is reasonable to assume that the negative effects of crowding are at least partially due to high staff workload, but previous crowding metrics based on high workload have not been generalisable to Swedish EDs and have not been associated with increased mortality, in contrast to, e.g.

Longitudinal Study on Correlations Between Body Image, Physical Activity, and the Subjective Well-Being Among Adolescents Aged 14–16

This study examined the relationship between physical activity, body image, and subjective well-being among Swedish adolescents over time. Surveying 2308 students, with 137 providing longitudinal data, we conducted a multivariate logistic regression analysis. No significant correlations were found between physical activity (p =.268), body functioning (p =.567), or body appearance (p =.075) at age

Carotid ultrasound and systematic coronary risk assessment 2 in the prediction of cardiovascular events

Aims: Subclinical carotid atherosclerosis adds predictive value to traditional risk factors for cardiovascular diseases (CVDs). Systematic Coronary Risk Assessment 2 (SCORE2), an algorithm composed of traditional risk factors, is a state-of-the-art to estimate the 10-year risk of first-onset CVDs. We aim to investigate whether and how subclinical carotid atherosclerosis affects the performance of

The concurrent validity of the Lund University Checklist for Incipient Exhaustion and the Karolinska Exhaustion Disorder Scale: a replication study

ObjectiveAs part of our research on Swedish school principals, we examined the concurrent validity between the Karolinska Exhaustion Disorder Scale (KEDS) and the Lund University Checklist for Incipient Exhaustion (LUCIE) in a cross-sectional study sample (N = 2670). Specifically, we examined: (a) to what extent LUCIE and KEDS identified the same individuals and their level of agreement, and (b) t

Political representatives' experiences of child participation in decision-making processes : A qualitative interview study

The aim was to explore political representatives' experiences of child participation in decision-making processes in municipalities. Interviews were conducted with Swedish politicians (n = 7) representing four municipalities. Qualitative content analysis was used to analyse the data. Politicians had experiences in child participation and methods for involving children and young people in the pract

Pharmacological modulation of vascular ageing: a review from VascAgeNet

Vascular ageing, characterized by structural and functional changes in blood vessels of which arterial stiffness and endothelial dysfunction are key components, is associated with increased risk of cardiovascular and other age-related diseases. As the global population continues to age, understanding the underlying mechanisms and developing effective therapeutic interventions to mitigate vascular

Regional differences in the incidence of lymphocytic and collagenous colitis over time

Background: In microscopic colitis (MC), the incidence has increased over the last decades. The aim of the present study was to determine the incidence of lymphocytic (LC) and collagenous colitis (CC) in the county Skåne (Scania), southern Sweden, during the period 2010–20 with focus both on the temporal and spatial variations. Methods: The MC diagnosis was retrieved from the biopsy registries at

Associations between birth parameters and skin autofluorescence advanced glycation end and ankle-brachial index in young adulthood : the Malmö Offspring Study

BACKGROUND: Low birth weight (LBW), advanced glycation end-products (AGE), and ankle-brachial index (ABI) have all been independently associated with risk of cardiovascular disease. Evidence is lacking on the effect of LBW on adult AGE, a marker of glucose metabolism, and ABI, a marker of peripheral atherosclerosis. The objective was to study these associations in a population-based cohort.METHODS

The Future of Consumption : How Technology, Sustainability and Wellbeing will Transform Retail and Customer Experience

This open access book presents three future consumption trends—technology, sustainability, and wellbeing—and discusses what impact those trends will have on the ways we shop. What will be important to the consumers of the future? And how will their retail experiences look and feel? Will technology, sustainability, and wellbeing trends fundamentally change how we consume? And how should retail mana

Introduction: The Future of Consumption

It is often said that we live in a consumer society. This does not just mean that we buy things regularly but also that consumption is an integral part of our daily lives. We have learned to think of ourselves as consumers, rather than citizens, in a variety of situations. Against this backdrop, retail organisations hold a strategically important position, not least because of the space they occup

Risk and outcomes of COVID-19 in patients with oxygen-dependent chronic respiratory failure– a national cohort study

Background: We aimed to evaluate cumulative occurrence and impact of COVID-19 in patients with chronic respiratory failure (CRF) treated with long-term oxygen therapy (LTOT). Material and methods: Data were obtained from the SCIFI-PEARL study on the entire Swedish population and on patients with oxygen-dependent CRF and no COVID-19 diagnosis before start of LTOT. Analyses were performed for three

Variability of the Modified Rankin Scale Score between Day 90 and 1 Year after Ischemic Stroke

Objective Studies indicate that the functional outcome evolves in the year after ischemic stroke onset. However, the traditional outcome measure in stroke trials is the modified Rankin Scale (mRS) at 90 days from onset. To determine mRS fluctuations in the first year after stroke, we examined data from 3 major stroke trials.MethodsIn a secondary analysis, we evaluated intrapatient mRS between 90 d

Influenza A subtype H3N2 is associated with an increased risk of hospital dissemination – an observational study over six influenza seasons

Background: Previous studies on hospital-acquired influenza (HAI) have not systematically evaluated the possible impact of different influenza subtypes. HAI has historically been associated with high mortality, but clinical consequences may be less severe in a modern hospital setting. Aims: To identify and quantify HAI for each season, investigate possible associations with varying influenza subty

Six-lead electrocardiography compared to single-lead electrocardiography and photoplethysmography of a wrist-worn device for atrial fibrillation detection controlled by premature atrial or ventricular contractions : six is smarter than one

Background: Smartwatches are commonly capable to record a lead-I-like electrocardiogram (ECG) and perform a photoplethysmography (PPG)-based atrial fibrillation (AF) detection. Wearable technologies repeatedly face the challenge of frequent premature beats, particularly in target populations for screening of AF. Objective: To investigate the potential diagnostic benefit of six-lead ECG compared to

Non-reproductive effects of follicle-stimulating hormone in young men

Objective: Follicle-stimulating hormone (FSH) receptor expression has been reported in many extra-gonadal tissues, raising the question of non-reproductive effects of FSH. Because of increasing usage of FSH in treatment of male infertility, deeper knowledge of possible harmful off-target effects of FSH is warranted. Methods: In total, 33 healthy young men (mean age 30 years) were included in the s

Who should operate patients presenting with emergent colon cancer? A comparison of short- and long-term outcome depending on surgical sub-specialization

Background: Colorectal cancer presents as emergencies in 20% of the cases. Emergency resection is associated with high postoperative morbidity and mortality. The specialization of the operating team in the emergency settings differs from the elective setting, which may have an impact on outcome. The aim of this study was to evaluate short- and long-term outcomes following emergent colon cancer sur