Search results

ObjectiveTo compare speech outcomes in 4 groups of 5-year-olds with cleft of the hard and soft palate: with Robin sequence without additional conditions (RS−), with Robin sequence with additional conditions (RS+), without Robin sequence with additional conditions (CP+), and without Robin sequence without additional conditions (CP−).DesignRegistry-based cohort study.SettingRegional public care univ

Background Colorectal polypectomy is operator dependent, with variable rates of complete resection. The currently available assessment tools do not provide specific competency-based evaluation of provider technique. We aimed to validate the Global Polypectomy Assessment Tool (GPAT), a novel competency assessment tool for colorectal polypectomy. Methods GPAT was derived from the ESGE Curriculum for

Background: Systemic lupus erythematosus (SLE) is an autoimmune disease with a heterogenous clinical picture. This study aimed to link genetic SLE predisposition with relevant clinical manifestations. Method: Datasets best corresponding to the 11 American College of Rheumatology 1982 (ACR-82) classification criteria for SLE in a large, public database (FinnGen consortium, >218,000 individuals) wer

Background: This study aimed to compare the effect on postoperative complications of combined prehabilitation targeting predefined co-existing risky SNAP factors with usual preoperative routines in surgical patients. Methods: This systematic review followed the PRISMA 2020 guideline and the protocol (CRD42022282611). Five databases were searched from inception to November 7, 2022 for randomised co

Context: Chronic dyspnea is subjective but with objective (measurable) consequences. It is often poorly assessed because people have modified their lifestyles to avoid exertion that generates dyspnea. Objectives: This study sought any relationship between respondents’ self-reported long-term breathlessness limiting exertion (hereafter chronic dyspnea) and distance travelled from the room in which

Aims: Economic simulation models, such as the IHE Type 2 Diabetes Cohort Model (IHE-DCM-T2), are used widely to inform resource allocation for Type 2 Diabetes (T2D) treatments. Recently, IHE-DCM-T2 was augmented with Japanese-specific risk equations to align with the Japanese healthcare context. This study extends prior model validation of IHE-DCM-T2 to cover the Japanese risk equations for applic

Background: Chronic low-grade inflammation is a well-known risk factor for coronary heart disease (CHD) and future cardiovascular events. Anti-inflammatory therapy can reduce the risk of ischemic cardiovascular disease (CVD) events following myocardial infarction (MI). However, it remains unknown to what extent inflammation at the time of an acute event predicts long-term outcomes. We explored whe

Objectives. This study aimed to estimate the prevalence of atrial fibrillation (AF) and identify its associated comorbidities in adults aged 45 years and older, using data from the Swedish general population study EpiHealth. Design. In a cross-sectional design, data of health history, lifestyle factors, anthropometric measurement, and 1-lead ECG recordings from participants in the EpiHealth study

Violent offenders are a heterogeneous group where criminogenic needs often are substantial and violent behaviors persistent. Risk, Need, and Responsivity (RNR)-based treatment has shown effect on reducing the risk for recidivism in violent crime, but the development of novel treatments is crucial in making the change process more effective. Virtual Reality (VR) technology may be a tool to improve

Lead-free perovskites (LFPs) are an emergent class of materials with great potential as next-generation candidates for energy and optoelectronic applications, offering a sustainable and non-toxic alternative to their lead-based counterparts. Computational studies play a central role in accelerating the discovery, design, and optimization of these materials by enabling predictive insights into elec

Objective: This study aimed to describe the regional, population-based, organised prostate cancer testing (OPT) programmes that are being introduced throughout Sweden: motives, structure, target population, diagnostic algorithm, quality control, outcomes, research, and future perspectives. Results: In 2018, the Swedish National Board of Health and Welfare renewed their recommendation against scree

BACKGROUND: Dupuytren disease (DD) is a benign fibroproliferative disorder affecting the hand. Although diabetes mellitus is a known risk factor, the underlying mechanisms behind this association remain unclear. This study aimed to examine the relationship between glycemic control and DD in type 1 (T1D) and type 2 diabetes (T2D), and to identify other metabolic risk factors influencing DD risk.MET

BackgroundLong-term oxygen therapy (LTOT) given for at least 15 hours/day improves survival in patients with severe chronic hypoxemia. However, the recent REDOX trial showed that LTOT prescribed for 24 hours/day was not superior to 15 hours/day in terms of death, hospitalizations, or self-reported outcomes. We aimed to examine the cost effectiveness of prescribing LTOT for 24 versus 15 hours/day.M

The primary regulator of testicular function is the gonadotropin-releasing hormone (GnRH). This hormone is secreted in a pulsatile manner by hypothalamic neurons. GnRH stimulates the synthesis and secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary gland. LH stimulates the synthesis of testosterone (T) after binding to specific receptors on Leyd

Introduction: Postnatal pesticide exposure and its impact on executive functioning (EF) in children and adolescents remains underexplored, particularly in African agricultural contexts. This study investigated associations between urinary pesticide biomarkers and EF in the Child health Agricultural Pesticide study in South Africa (CapSA). Methods: Data from 445 participants (mean age: 10.6 years;

Background and aims: Gynoid fat (hip-thigh subcutaneous adiposity) is metabolically favorable, yet its genetic architecture and impact on liver diseases are unknown. We aimed to identify genetic determinants of gynoid tissue fat percentage (GTFP) and explore their clinical implications to liver disease. Methods: We conducted a genome-wide association study (GWAS) in 37,385 European individuals fro

BackgroundOsteocalcin is a bone-specific protein involving many physiological processes, primarily bone turnover. Also closely related to the musculoskeletal system is the frailty syndrome.AimTo investigate if circulating osteocalcin levels and frailty are associated in the old, and in addition, if the presumed association is mediated through alterations in bone.Methods999 community-dwelling women