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The Future Book or the Future of the Book

Our paper begins in the early days of the 2000s, a time when techno-futurist imaginaries sprung up around two emerging digital book formats: the e-book and the digitalized audiobook. However, while many actors celebrated the opportunities they saw in these new formats, many worried over what the consequences a digital future would have for the traditional printed book. Based on qualitative content

Positivity of entropy production for the three-level maser

Entropy production is a key concept of thermodynamics and allows one to analyze the operation of engines. For the Scovil-Schulz-DuBois heat engine, the archetypal three-level thermal maser coupled to thermal baths, it was argued that the common definition of heat flow may provide negative entropy production for certain parameters [Boukobza and Tannor, Phys. Rev. Lett. 98, 240601 (2007)PRLTAO0031-9

Immune modulation via T regulatory cell enhancement : Disease-modifying therapies for autoimmunity and their potential for chronic allergic and inflammatory diseases—An EAACI position paper of the Task Force on Immunopharmacology (TIPCO)

Therapeutic advances using targeted biologicals and small-molecule drugs have achieved significant success in the treatment of chronic allergic, autoimmune, and inflammatory diseases particularly for some patients with severe, treatment-resistant forms. This has been aided by improved identification of disease phenotypes. Despite these achievements, not all severe forms of chronic inflammatory and

Socioeconomic Factors in Patients with Ulnar Nerve Compression at the Elbow : A National Registry-Based Study

Aims. To investigate demographics and socioeconomic status in patients with ulnar nerve compression and the influence of socioeconomic factors on patient-reported outcome measurements (PROM) as evaluated by QuickDASH (short version of Disabilities of Arm, Shoulder and Hand) after surgery for ulnar nerve compression at the elbow. Methods. Patients operated for primary ulnar nerve compression from 2

Observing the emergence of a quantum phase transition shell by shell

Many-body physics describes phenomena that cannot be understood by looking only at the constituents of a system1. Striking examples are broken symmetry, phase transitions and collective excitations2. To understand how such collective behaviour emerges as a system is gradually assembled from individual particles has been a goal in atomic, nuclear and solid-state physics for decades3–6. Here we obse

Signatures of odd-frequency pairing in the Josephson junction current noise

Odd-frequency (odd−ω) electron pair correlations naturally appear at the interface between BCS superconductors and other materials. The detection of odd−ω pairs, which are necessarily nonlocal in time, is still an open problem. The main reason is that they do not contribute to static measurements described by time-local correlation functions. Therefore, dynamical measurements, which depend on nonl

Effect of motor imagery on enjoyment in knee-injury prevention and rehabilitation training : A randomized crossover study

Objectives: The novel MOTor Imagery to Facilitate Sensorimotor Re-Learning (MOTIFS) model takes a uniquely holistic approach by integrating mental and physical aspects into current training programs. The aim of this trial was to evaluate enjoyment of MOTIFS training as compared to Care-as-Usual (CaU) knee injury and/or rehabilitation training. The primary hypothesis was that enjoyment would be gre

Precarious employment and general, mental and physical health in Stockholm, Sweden : a cross-sectional study

Objectives: To investigate the association between precarious employment and health in a sample of non-standard employees in Stockholm County, Sweden, by addressing three specific research questions: is the degree of precarious employment (low, moderate, high) associated with self-rated.. (a) general health, (b) mental health, (c) musculoskeletal pain? Methods: Web-based respondent-driven sampling

Back pain is also improved by lumbar disc herniation surgery

Background and purpose — Indication for lumbar disc herniation (LDH) surgery is usually to relieve sciatica. We evaluated whether back pain also decreases after LDH surgery. Patients and methods — In the Swedish register for spinal surgery (SweSpine) we identified 14,097 patients aged 20–64 years, with pre- and postoperative data, who in 2000–2016 had LDH surgery. We calculated 1-year improvement

The implications of an aging population and increased obesity for knee arthroplasty rates in Sweden : a register-based study

Background and purpose — Total knee arthroplasty (TKA) has increased substantially in Sweden. We quantified the relative risk for TKA in the Swedish population for different BMI categories and age groups to investigate whether the continued increase in TKA is attributable to increased prevalence of obesity and elderly people in the population, and to put forward model predictions for coming needs

Variation and trends in reasons for knee replacement revision : a multi-registry study of revision burden

Background and purpose — Studies describing time-related change in reasons for knee replacement revision have been limited to single regions or institutions, commonly analyze only 1st revisions, and may not reflect true caseloads or findings from other areas. We used revision procedure data from 3 arthroplasty registries to determine trends and differences in knee replacement revision diagnoses. P

Subclinical macroangiopathic target organ damage in type 1 diabetes mellitus patients

Purpose: We have summarized key studies regarding the assessment of subclinical macroangiopathic target organ damage (TOD) in type 1 diabetes mellitus (T1DM). Results: Although chronic complications resulting from hyperglycemia, in particular macroangiopathies, are still the first cause of death in T1DM, there has been growing recognition of the role of hypoglycemia in cardiovascular morbidity and

Optical Force-Induced Dynamics of Assembling, Rearrangement, and Three-Dimensional Pistol-like Ejection of Microparticles at the Solution Surface

Optical trapping and assembling dynamics of polystyrene microparticles (MPs) of 1 μm in diameter are studied at its solution-air surface using a widefield microscope. Upon switching on the intense 1064 nm laser, the MPs are gathered, forming a single concentric circle (CC)-like assembly larger than the focus. It consists of a few tens of MPs, and the central part of the assembly shows structural c

Tuning lipid structure by bile salts: Hexosomes for topical administration of catechin

The delivery of bio-active molecules through the skin is challenging given the complex structure of its outer layer, the stratum corneum. Here we explore the possibility to encapsulate natural compounds into nanocarriers containing permeation enhancers that can affect the fluidity of the stratum corneum lipids. This approach is expected to facilitate dermal or transdermal release. For this purpose

Tailoring the self-assembly, interfacial properties and rheological behaviour of sugar-based surfactants

Surfactants are important ingredients in many formulated products used in everyday life. Many of these surfactants originates from fossil-based materials and degrades slowly in aquatic systems. As society strives towards having a smaller environmental footprint, surfactants that are non-toxic, biodegradable and can be synthesized from renewable raw materials need to be developed. To this end sugar

Functionalized single-walled carbon-nanotube-blended P3HT-based high performance memory behavior thin-film transistor devices

We report on the fabrication and transport properties of single-walled carbon nanotubes (SWCNT) blended with P3HT (poly 3-hexyl thiophene-2, 5-diyl). The composite is used as a hybrid organic active channel transistor. The performances of the fabricated devices were investigated as a function of the SWCNTs' loads in the composite, and their response evaluated under white light illumination. Our re

The association between sociodemographic characteristics and dementia in patients with atrial fibrillation

Objectives: Association between socio-demographic factors and dementia risk is studied in general but not for atrial fibrillation (AF) patients. Methods: We studied AF patients ≥ 45 years in Sweden 1998–2012 (n = 537,513) using the Total Population Register for socio-demographic factors, the Swedish Cause of Death Register, and the National Patient Register (NPR) for incident dementia. Cox regress

Exploring multidimensional operationalizations of precarious employment in swedish register data – a typological approach and a summative score approach

Objectives This study aimed to explore multidimensional operationalizations of precarious employment (PE) in Swedish register data using two approaches: (i) a typological approach and (ii) a dimensional, summative scale approach. It also examined the distribution of sociodemographic and occupational characteristics of precarious employees in Sweden. Method Register data was retrieved on individual

Ventricular-arterial coupling as a potential therapeutic target in diabetes

Patients with type 2 diabetes (T2D) are at high risk of cardiovascular complications. Novel anti-diabetic medications such as sodium-glucose cotransporter-2 inhibitors (SGLT-2i) and Glucagon-like peptide-1 receptor agonists (GLP-1RA) have been shown to possess cardiac and renal protective effects beyond their ability to lower plasma glucose. Use of SGLT-2i and GLP-1RA in patients with T2D and hear

Hydrophobic and Hydrophilic Conjugated Polymer Dots as Binary Photocatalysts for Enhanced Visible-Light-Driven Hydrogen Evolution through Förster Resonance Energy Transfer

Organic semiconducting polymers exhibited promising photocatalytic behavior for hydrogen (H2) evolution, especially when prepared in the form of polymer dots (Pdots). However, the Pdot structures were formed using common nonconjugated amphiphilic polymers, which have a negative effect on charge transfer between photocatalysts and reactants and are unable to participate in the photocatalytic reacti